Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

A series of new imidazole carboxylic esters (carbamates) and N-acylimidazole derivatives of betulin and betulinic acid ( 14– 29) have been synthesized. The new compounds were screened for in vitro cytotoxicity activity against human cancer cell lines HepG2, Jurkat and HeLa. A number of compounds hav...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2009-09, Vol.17 (17), p.6241-6250
Hauptverfasser:	Santos, Rita C., Salvador, Jorge A.R., Marín, Silvia, Cascante, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Betulinic acid Biological and medical sciences Cell Line, Tumor Cytotoxicity Drug Screening Assays, Antitumor General aspects Humans Imidazole Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - toxicity Triterpenoids
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