Discovery of TAS2R14 Agonists from Platycodon grandiflorum Using Virtual Screening and Affinity Screening Based on a Novel TAS2R14-Functionalized HEMT Sensor Combined with UPLC–MS Analysis

TAS2R14 is of great potential as a therapeutic target against asthma, and the discovery of TAS2R14 agonists can be very valuable for treating this disease. Herein, we developed a strategy using virtual screening and affinity screening based on a fabricated biosensor combined with UPLC–MS analysis to...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2018-11, Vol.66 (44), p.11663-11671
Hauptverfasser:	Wang, Zhi-Xin, Zhang, Yu-Xin, Zeng, Yan-Ling, Li, Xi, Chen, Zhao, Luo, Jia-Ming, Zhang, Yang, Zhang, Yan-Ling, Qiao, Yan-Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - methods Drug Evaluation, Preclinical - instrumentation Drug Evaluation, Preclinical - methods Mass Spectrometry - methods Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Roots - chemistry Platycodon - chemistry Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism
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