miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes
Harnessing the mechanisms underlying the exacerbated vascular remodeling in diabetes mellitus (DM) is pivotal to prevent the high toll of vascular diseases in patients with DM. miRNA regulates vascular smooth muscle cell (VSMC) phenotypic switch. However, miRNA modulation of the detrimental diabetic...
Gespeichert in:
| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2018-12, Vol.67 (12), p.2554-2568 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2568 |
|---|---|
| container_issue | 12 |
| container_start_page | 2554 |
| container_title | Diabetes (New York, N.Y.) |
| container_volume | 67 |
| creator | Torella, Daniele Iaconetti, Claudio Tarallo, Roberta Marino, Fabiola Giurato, Giorgio Veneziano, Claudia Aquila, Iolanda Scalise, Mariangela Mancuso, Teresa Cianflone, Eleonora Valeriano, Chiara Marotta, Pina Tammè, Laura Vicinanza, Carla Sasso, Ferdinando C Cozzolino, Domenico Torella, Michele Weisz, Alessandro Indolfi, Ciro |
| description | Harnessing the mechanisms underlying the exacerbated vascular remodeling in diabetes mellitus (DM) is pivotal to prevent the high toll of vascular diseases in patients with DM. miRNA regulates vascular smooth muscle cell (VSMC) phenotypic switch. However, miRNA modulation of the detrimental diabetic VSMC phenotype is underexplored. Streptozotocin-induced type 1 DM (T1DM) Wistar rats and type 2 DM (T2DM) Zucker rats underwent right carotid artery experimental angioplasty, and global miRNA/mRNA expression profiling was obtained by RNA sequencing (RNA-Seq). Two days after injury, a set of six miRNAs were found to be uniquely downregulated or upregulated in VSMCs both in T1DM and T2DM. Among these miRNAs, miR-29c and miR-204 were the most significantly misregulated in atherosclerotic plaques from patients with DM. miR-29c overexpression and miR-204 inhibition per se attenuated VSMC phenotypic switch in DM. Concomitant miR-29c overexpression and miR-204 inhibition fostered an additive reduction in VSMC proliferation. Epithelial membrane protein 2 (
) and Caveolin-1 (
) mRNAs were identified as direct targets of miR-29c and miR-204, respectively. Importantly, contemporary miR-29c overexpression and miR-204 inhibition in the injured artery robustly reduced arterial stenosis in DM rats. Thus, contemporaneous miR-29c activation and miR-204 inhibition in DM arterial tissues is necessary and sufficient to prevent the exaggerated VSMC growth upon injury. |
| doi_str_mv | 10.2337/db17-1434 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2113262783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2154726122</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-be82b0c16a039df58374b795ef267c78b81b61fe73ea778fb6d4931566c85f6e3</originalsourceid><addsrcrecordid>eNpdkElPwzAQhS0EoqVw4A8gS1zgEPCS2MmxKkuRyqKyiFuIkzFNlcTFTpD673HUwgHNYaQ33zw9PYSOKblgnMvLQlEZ0JCHO2hIE54EnMn3XTQkhLKAykQO0IFzS0KI8LOPBpywyMt8iD7qcv4wxnP47KqsLU2DjcbtAvB0vQK7sqYqNVh_-Qb8tIDGtF7vmbfM5f7F4ufamHaB7zuXV4AnUFUOlw2-KjMFLbhDtKezysHRdo_Q6831y2QazB5v7ybjWZDzMG4DBTFTJKciIzwpdBRzGSqZRKCZkLmMVUyVoBokh0zKWCtRhAmnkRB5HGkBfITONr4-81cHrk3r0uU-TdaA6VzKKOVMMBlzj57-Q5ems41P56kolExQxjx1vqFya5yzoNOVLevMrlNK0r72tK897Wv37MnWsVM1FH_kb8_8B0nHfEw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2154726122</pqid></control><display><type>article</type><title>miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Torella, Daniele ; Iaconetti, Claudio ; Tarallo, Roberta ; Marino, Fabiola ; Giurato, Giorgio ; Veneziano, Claudia ; Aquila, Iolanda ; Scalise, Mariangela ; Mancuso, Teresa ; Cianflone, Eleonora ; Valeriano, Chiara ; Marotta, Pina ; Tammè, Laura ; Vicinanza, Carla ; Sasso, Ferdinando C ; Cozzolino, Domenico ; Torella, Michele ; Weisz, Alessandro ; Indolfi, Ciro</creator><creatorcontrib>Torella, Daniele ; Iaconetti, Claudio ; Tarallo, Roberta ; Marino, Fabiola ; Giurato, Giorgio ; Veneziano, Claudia ; Aquila, Iolanda ; Scalise, Mariangela ; Mancuso, Teresa ; Cianflone, Eleonora ; Valeriano, Chiara ; Marotta, Pina ; Tammè, Laura ; Vicinanza, Carla ; Sasso, Ferdinando C ; Cozzolino, Domenico ; Torella, Michele ; Weisz, Alessandro ; Indolfi, Ciro</creatorcontrib><description>Harnessing the mechanisms underlying the exacerbated vascular remodeling in diabetes mellitus (DM) is pivotal to prevent the high toll of vascular diseases in patients with DM. miRNA regulates vascular smooth muscle cell (VSMC) phenotypic switch. However, miRNA modulation of the detrimental diabetic VSMC phenotype is underexplored. Streptozotocin-induced type 1 DM (T1DM) Wistar rats and type 2 DM (T2DM) Zucker rats underwent right carotid artery experimental angioplasty, and global miRNA/mRNA expression profiling was obtained by RNA sequencing (RNA-Seq). Two days after injury, a set of six miRNAs were found to be uniquely downregulated or upregulated in VSMCs both in T1DM and T2DM. Among these miRNAs, miR-29c and miR-204 were the most significantly misregulated in atherosclerotic plaques from patients with DM. miR-29c overexpression and miR-204 inhibition per se attenuated VSMC phenotypic switch in DM. Concomitant miR-29c overexpression and miR-204 inhibition fostered an additive reduction in VSMC proliferation. Epithelial membrane protein 2 (
) and Caveolin-1 (
) mRNAs were identified as direct targets of miR-29c and miR-204, respectively. Importantly, contemporary miR-29c overexpression and miR-204 inhibition in the injured artery robustly reduced arterial stenosis in DM rats. Thus, contemporaneous miR-29c activation and miR-204 inhibition in DM arterial tissues is necessary and sufficient to prevent the exaggerated VSMC growth upon injury.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db17-1434</identifier><identifier>PMID: 30257973</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Angioplasty ; Animals ; Arteriosclerosis ; Carotid artery ; Caveolin ; Caveolin-1 ; Cell Proliferation - physiology ; Cells ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - pathology ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - pathology ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - pathology ; Gene expression ; Humans ; Male ; Membrane proteins ; MicroRNAs - metabolism ; miRNA ; Muscle, Smooth, Vascular - metabolism ; Muscle, Smooth, Vascular - pathology ; Myocytes, Smooth Muscle - metabolism ; Myocytes, Smooth Muscle - pathology ; Phenotypes ; Plaque, Atherosclerotic - metabolism ; Plaque, Atherosclerotic - pathology ; Plaques ; Rats ; Rats, Wistar ; Regulation ; Ribonucleic acid ; RNA ; Smooth muscle ; Stenosis ; Streptozocin ; Vascular diseases</subject><ispartof>Diabetes (New York, N.Y.), 2018-12, Vol.67 (12), p.2554-2568</ispartof><rights>2018 by the American Diabetes Association.</rights><rights>Copyright American Diabetes Association Dec 1, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-be82b0c16a039df58374b795ef267c78b81b61fe73ea778fb6d4931566c85f6e3</citedby><cites>FETCH-LOGICAL-c348t-be82b0c16a039df58374b795ef267c78b81b61fe73ea778fb6d4931566c85f6e3</cites><orcidid>0000-0002-4915-5084</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30257973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torella, Daniele</creatorcontrib><creatorcontrib>Iaconetti, Claudio</creatorcontrib><creatorcontrib>Tarallo, Roberta</creatorcontrib><creatorcontrib>Marino, Fabiola</creatorcontrib><creatorcontrib>Giurato, Giorgio</creatorcontrib><creatorcontrib>Veneziano, Claudia</creatorcontrib><creatorcontrib>Aquila, Iolanda</creatorcontrib><creatorcontrib>Scalise, Mariangela</creatorcontrib><creatorcontrib>Mancuso, Teresa</creatorcontrib><creatorcontrib>Cianflone, Eleonora</creatorcontrib><creatorcontrib>Valeriano, Chiara</creatorcontrib><creatorcontrib>Marotta, Pina</creatorcontrib><creatorcontrib>Tammè, Laura</creatorcontrib><creatorcontrib>Vicinanza, Carla</creatorcontrib><creatorcontrib>Sasso, Ferdinando C</creatorcontrib><creatorcontrib>Cozzolino, Domenico</creatorcontrib><creatorcontrib>Torella, Michele</creatorcontrib><creatorcontrib>Weisz, Alessandro</creatorcontrib><creatorcontrib>Indolfi, Ciro</creatorcontrib><title>miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>Harnessing the mechanisms underlying the exacerbated vascular remodeling in diabetes mellitus (DM) is pivotal to prevent the high toll of vascular diseases in patients with DM. miRNA regulates vascular smooth muscle cell (VSMC) phenotypic switch. However, miRNA modulation of the detrimental diabetic VSMC phenotype is underexplored. Streptozotocin-induced type 1 DM (T1DM) Wistar rats and type 2 DM (T2DM) Zucker rats underwent right carotid artery experimental angioplasty, and global miRNA/mRNA expression profiling was obtained by RNA sequencing (RNA-Seq). Two days after injury, a set of six miRNAs were found to be uniquely downregulated or upregulated in VSMCs both in T1DM and T2DM. Among these miRNAs, miR-29c and miR-204 were the most significantly misregulated in atherosclerotic plaques from patients with DM. miR-29c overexpression and miR-204 inhibition per se attenuated VSMC phenotypic switch in DM. Concomitant miR-29c overexpression and miR-204 inhibition fostered an additive reduction in VSMC proliferation. Epithelial membrane protein 2 (
) and Caveolin-1 (
) mRNAs were identified as direct targets of miR-29c and miR-204, respectively. Importantly, contemporary miR-29c overexpression and miR-204 inhibition in the injured artery robustly reduced arterial stenosis in DM rats. Thus, contemporaneous miR-29c activation and miR-204 inhibition in DM arterial tissues is necessary and sufficient to prevent the exaggerated VSMC growth upon injury.</description><subject>Angioplasty</subject><subject>Animals</subject><subject>Arteriosclerosis</subject><subject>Carotid artery</subject><subject>Caveolin</subject><subject>Caveolin-1</subject><subject>Cell Proliferation - physiology</subject><subject>Cells</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes Mellitus, Type 1 - pathology</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Male</subject><subject>Membrane proteins</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Myocytes, Smooth Muscle - metabolism</subject><subject>Myocytes, Smooth Muscle - pathology</subject><subject>Phenotypes</subject><subject>Plaque, Atherosclerotic - metabolism</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Plaques</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regulation</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Smooth muscle</subject><subject>Stenosis</subject><subject>Streptozocin</subject><subject>Vascular diseases</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkElPwzAQhS0EoqVw4A8gS1zgEPCS2MmxKkuRyqKyiFuIkzFNlcTFTpD673HUwgHNYaQ33zw9PYSOKblgnMvLQlEZ0JCHO2hIE54EnMn3XTQkhLKAykQO0IFzS0KI8LOPBpywyMt8iD7qcv4wxnP47KqsLU2DjcbtAvB0vQK7sqYqNVh_-Qb8tIDGtF7vmbfM5f7F4ufamHaB7zuXV4AnUFUOlw2-KjMFLbhDtKezysHRdo_Q6831y2QazB5v7ybjWZDzMG4DBTFTJKciIzwpdBRzGSqZRKCZkLmMVUyVoBokh0zKWCtRhAmnkRB5HGkBfITONr4-81cHrk3r0uU-TdaA6VzKKOVMMBlzj57-Q5ems41P56kolExQxjx1vqFya5yzoNOVLevMrlNK0r72tK897Wv37MnWsVM1FH_kb8_8B0nHfEw</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Torella, Daniele</creator><creator>Iaconetti, Claudio</creator><creator>Tarallo, Roberta</creator><creator>Marino, Fabiola</creator><creator>Giurato, Giorgio</creator><creator>Veneziano, Claudia</creator><creator>Aquila, Iolanda</creator><creator>Scalise, Mariangela</creator><creator>Mancuso, Teresa</creator><creator>Cianflone, Eleonora</creator><creator>Valeriano, Chiara</creator><creator>Marotta, Pina</creator><creator>Tammè, Laura</creator><creator>Vicinanza, Carla</creator><creator>Sasso, Ferdinando C</creator><creator>Cozzolino, Domenico</creator><creator>Torella, Michele</creator><creator>Weisz, Alessandro</creator><creator>Indolfi, Ciro</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4915-5084</orcidid></search><sort><creationdate>201812</creationdate><title>miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes</title><author>Torella, Daniele ; Iaconetti, Claudio ; Tarallo, Roberta ; Marino, Fabiola ; Giurato, Giorgio ; Veneziano, Claudia ; Aquila, Iolanda ; Scalise, Mariangela ; Mancuso, Teresa ; Cianflone, Eleonora ; Valeriano, Chiara ; Marotta, Pina ; Tammè, Laura ; Vicinanza, Carla ; Sasso, Ferdinando C ; Cozzolino, Domenico ; Torella, Michele ; Weisz, Alessandro ; Indolfi, Ciro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-be82b0c16a039df58374b795ef267c78b81b61fe73ea778fb6d4931566c85f6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Angioplasty</topic><topic>Animals</topic><topic>Arteriosclerosis</topic><topic>Carotid artery</topic><topic>Caveolin</topic><topic>Caveolin-1</topic><topic>Cell Proliferation - physiology</topic><topic>Cells</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes Mellitus, Type 1 - pathology</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Male</topic><topic>Membrane proteins</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Myocytes, Smooth Muscle - metabolism</topic><topic>Myocytes, Smooth Muscle - pathology</topic><topic>Phenotypes</topic><topic>Plaque, Atherosclerotic - metabolism</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Plaques</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regulation</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Smooth muscle</topic><topic>Stenosis</topic><topic>Streptozocin</topic><topic>Vascular diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torella, Daniele</creatorcontrib><creatorcontrib>Iaconetti, Claudio</creatorcontrib><creatorcontrib>Tarallo, Roberta</creatorcontrib><creatorcontrib>Marino, Fabiola</creatorcontrib><creatorcontrib>Giurato, Giorgio</creatorcontrib><creatorcontrib>Veneziano, Claudia</creatorcontrib><creatorcontrib>Aquila, Iolanda</creatorcontrib><creatorcontrib>Scalise, Mariangela</creatorcontrib><creatorcontrib>Mancuso, Teresa</creatorcontrib><creatorcontrib>Cianflone, Eleonora</creatorcontrib><creatorcontrib>Valeriano, Chiara</creatorcontrib><creatorcontrib>Marotta, Pina</creatorcontrib><creatorcontrib>Tammè, Laura</creatorcontrib><creatorcontrib>Vicinanza, Carla</creatorcontrib><creatorcontrib>Sasso, Ferdinando C</creatorcontrib><creatorcontrib>Cozzolino, Domenico</creatorcontrib><creatorcontrib>Torella, Michele</creatorcontrib><creatorcontrib>Weisz, Alessandro</creatorcontrib><creatorcontrib>Indolfi, Ciro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torella, Daniele</au><au>Iaconetti, Claudio</au><au>Tarallo, Roberta</au><au>Marino, Fabiola</au><au>Giurato, Giorgio</au><au>Veneziano, Claudia</au><au>Aquila, Iolanda</au><au>Scalise, Mariangela</au><au>Mancuso, Teresa</au><au>Cianflone, Eleonora</au><au>Valeriano, Chiara</au><au>Marotta, Pina</au><au>Tammè, Laura</au><au>Vicinanza, Carla</au><au>Sasso, Ferdinando C</au><au>Cozzolino, Domenico</au><au>Torella, Michele</au><au>Weisz, Alessandro</au><au>Indolfi, Ciro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2018-12</date><risdate>2018</risdate><volume>67</volume><issue>12</issue><spage>2554</spage><epage>2568</epage><pages>2554-2568</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><abstract>Harnessing the mechanisms underlying the exacerbated vascular remodeling in diabetes mellitus (DM) is pivotal to prevent the high toll of vascular diseases in patients with DM. miRNA regulates vascular smooth muscle cell (VSMC) phenotypic switch. However, miRNA modulation of the detrimental diabetic VSMC phenotype is underexplored. Streptozotocin-induced type 1 DM (T1DM) Wistar rats and type 2 DM (T2DM) Zucker rats underwent right carotid artery experimental angioplasty, and global miRNA/mRNA expression profiling was obtained by RNA sequencing (RNA-Seq). Two days after injury, a set of six miRNAs were found to be uniquely downregulated or upregulated in VSMCs both in T1DM and T2DM. Among these miRNAs, miR-29c and miR-204 were the most significantly misregulated in atherosclerotic plaques from patients with DM. miR-29c overexpression and miR-204 inhibition per se attenuated VSMC phenotypic switch in DM. Concomitant miR-29c overexpression and miR-204 inhibition fostered an additive reduction in VSMC proliferation. Epithelial membrane protein 2 (
) and Caveolin-1 (
) mRNAs were identified as direct targets of miR-29c and miR-204, respectively. Importantly, contemporary miR-29c overexpression and miR-204 inhibition in the injured artery robustly reduced arterial stenosis in DM rats. Thus, contemporaneous miR-29c activation and miR-204 inhibition in DM arterial tissues is necessary and sufficient to prevent the exaggerated VSMC growth upon injury.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>30257973</pmid><doi>10.2337/db17-1434</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-4915-5084</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1797 |
| ispartof | Diabetes (New York, N.Y.), 2018-12, Vol.67 (12), p.2554-2568 |
| issn | 0012-1797 1939-327X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2113262783 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Angioplasty Animals Arteriosclerosis Carotid artery Caveolin Caveolin-1 Cell Proliferation - physiology Cells Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Gene expression Humans Male Membrane proteins MicroRNAs - metabolism miRNA Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Phenotypes Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Plaques Rats Rats, Wistar Regulation Ribonucleic acid RNA Smooth muscle Stenosis Streptozocin Vascular diseases |
| title | miRNA Regulation of the Hyperproliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T20%3A45%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=miRNA%20Regulation%20of%20the%20Hyperproliferative%20Phenotype%20of%20Vascular%20Smooth%20Muscle%20Cells%20in%20Diabetes&rft.jtitle=Diabetes%20(New%20York,%20N.Y.)&rft.au=Torella,%20Daniele&rft.date=2018-12&rft.volume=67&rft.issue=12&rft.spage=2554&rft.epage=2568&rft.pages=2554-2568&rft.issn=0012-1797&rft.eissn=1939-327X&rft_id=info:doi/10.2337/db17-1434&rft_dat=%3Cproquest_cross%3E2154726122%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2154726122&rft_id=info:pmid/30257973&rfr_iscdi=true |