Involvement of complement 3 in the salt-sensitive hypertension by activation of renal renin-angiotensin system in spontaneously hypertensive rats

We previously showed that complement 3 (C3) is highly expressed in mesenchymal tissues in spontaneously hypertensive rats (SHR). We targeted C3 gene by zinc-finger nuclease (ZFN) gene-editing technology and investigated blood pressure and phenotype in SHR. Blood pressure was measured by tail-cuff an...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2018-12, Vol.315 (6), p.F1747-F1758
Hauptverfasser:	Negishi, Eriko, Fukuda, Noboru, Otsuki, Tomoyasu, Katakawa, Mayumi, Komatsu, Kazutoshi, Chen, Lan, Tanaka, Sho, Kobayashi, Hiroki, Hatanaka, Yoshinari, Ueno, Takahiro, Endo, Morito, Mashimo, Tomoji, Nishiyama, Akira, Abe, Masanori
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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