Tricholumin A, a Highly Transformed Ergosterol Derivative from the Alga-Endophytic Fungus Trichoderma asperellum
Tricholumin A (1) with an unprecedented carbon skeleton was isolated from the fungus Trichoderma asperellum cf44-2, an endophyte from the marine brown alga Sargassum sp. Its structure and relative configuration were identified by extensive 1D/2D NMR and mass spectrometric data, and the absolute conf...
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| Veröffentlicht in: | Organic letters 2018-10, Vol.20 (19), p.6306-6309 |
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| container_end_page | 6309 |
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| container_issue | 19 |
| container_start_page | 6306 |
| container_title | Organic letters |
| container_volume | 20 |
| creator | Song, Yin-Ping Shi, Zhen-Zhen Miao, Feng-Ping Fang, Sheng-Tao Yin, Xiu-Li Ji, Nai-Yun |
| description | Tricholumin A (1) with an unprecedented carbon skeleton was isolated from the fungus Trichoderma asperellum cf44-2, an endophyte from the marine brown alga Sargassum sp. Its structure and relative configuration were identified by extensive 1D/2D NMR and mass spectrometric data, and the absolute configuration was assigned by X-ray diffraction and ECD calculations. Compound 1 represents a highly transformed ergosterol derivative, and it exhibited inhibition of some pathogenic microbes and marine phytoplankton species. |
| doi_str_mv | 10.1021/acs.orglett.8b02821 |
| format | Article |
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Lett</addtitle><date>2018-10-05</date><risdate>2018</risdate><volume>20</volume><issue>19</issue><spage>6306</spage><epage>6309</epage><pages>6306-6309</pages><issn>1523-7060</issn><eissn>1523-7052</eissn><abstract>Tricholumin A (1) with an unprecedented carbon skeleton was isolated from the fungus Trichoderma asperellum cf44-2, an endophyte from the marine brown alga Sargassum sp. Its structure and relative configuration were identified by extensive 1D/2D NMR and mass spectrometric data, and the absolute configuration was assigned by X-ray diffraction and ECD calculations. Compound 1 represents a highly transformed ergosterol derivative, and it exhibited inhibition of some pathogenic microbes and marine phytoplankton species.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>30256119</pmid><doi>10.1021/acs.orglett.8b02821</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-6526-4731</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2018-10, Vol.20 (19), p.6306-6309 |
| issn | 1523-7060 1523-7052 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Endophytes - chemistry Endophytes - isolation & purification Ergosterol - chemistry Ergosterol - isolation & purification Molecular Structure Phytoplankton - drug effects Sargassum - microbiology Structure-Activity Relationship Trichoderma - chemistry Trichoderma - isolation & purification |
| title | Tricholumin A, a Highly Transformed Ergosterol Derivative from the Alga-Endophytic Fungus Trichoderma asperellum |
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