Positron emission tomography with 4-[18F]fluoro-L-m-tyrosine in MPTP-induced hemiparkinsonian monkeys
PET imaging studies with 4-[18F]fluoro-L-m-tyrosine (FMT) in normal macaca monkeys showed selective accumulations of radioactivity in the striatum with time. In monkeys rendered hemiparkinsonian by intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), FMT uptake was eliminate...
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| Veröffentlicht in: | Annals of nuclear medicine 1995-08, Vol.9 (3), p.119-123 |
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| container_title | Annals of nuclear medicine |
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| creator | Hayase, N Tomiyoshi, K Watanabe, K Horikoshi, S Shibasaki, T Ohye, C |
| description | PET imaging studies with 4-[18F]fluoro-L-m-tyrosine (FMT) in normal macaca monkeys showed selective accumulations of radioactivity in the striatum with time. In monkeys rendered hemiparkinsonian by intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), FMT uptake was eliminated in the lesioned striatum. FMT-PET studies were able to detect dopaminergic terminals in both normal and hemiparkinsonian monkeys, and clearly showed a reduction in aromatic L-amino acid decarboxylase (AAAD) activities in the MPTP-lesioned striatum. These results show that FMT is promising as a PET tracer for the evaluation of central dopaminergic systems in parkinsonism. |
| doi_str_mv | 10.1007/BF03165037 |
| format | Article |
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In monkeys rendered hemiparkinsonian by intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), FMT uptake was eliminated in the lesioned striatum. FMT-PET studies were able to detect dopaminergic terminals in both normal and hemiparkinsonian monkeys, and clearly showed a reduction in aromatic L-amino acid decarboxylase (AAAD) activities in the MPTP-lesioned striatum. These results show that FMT is promising as a PET tracer for the evaluation of central dopaminergic systems in parkinsonism.</description><subject>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</subject><subject>Animals</subject><subject>Central Nervous System Stimulants - pharmacokinetics</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - metabolism</subject><subject>Fluorine Radioisotopes - pharmacokinetics</subject><subject>Macaca</subject><subject>Parkinson Disease, Secondary - chemically induced</subject><subject>Parkinson Disease, Secondary - diagnostic imaging</subject><subject>Parkinson Disease, Secondary - metabolism</subject><subject>Reference Values</subject><subject>Tomography, Emission-Computed - methods</subject><subject>Tyrosine - analogs & derivatives</subject><subject>Tyrosine - pharmacokinetics</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAYhoMoc04v3oWePAjR_Gyzow6nwsQd5kmkpO0XF7cmNWmR_vdWNvT0fYfnfeF9EDqn5JoSkt3czQmnqSQ8O0BjqlKBU8H5IRqTKRU4oyo7RicxfhLClFRshEZKciEVHyNY-mjb4F0CtY3RDk_ra_8RdLPuk2_brhOB36iav5tt54PHC1zjtg9DykFiXfK8XC2xdVVXQpWsh5JGh4110TurXVJ7t4E-nqIjo7cRzvZ3gl7n96vZI168PDzNbhe4ZDJrsdRpBrosqBEpN0wZXmWmyorUFHRKQbDKUFBasLQynKWiAKGlIIUkEjRozSfoctfbBP_VQWzzYVQJ26124LuYM0oZE1QN4NUOLIclMYDJm2BrHfqckvzXaf7vdIAv9q1dUUP1h-4l8h_RQHLN</recordid><startdate>199508</startdate><enddate>199508</enddate><creator>Hayase, N</creator><creator>Tomiyoshi, K</creator><creator>Watanabe, K</creator><creator>Horikoshi, S</creator><creator>Shibasaki, T</creator><creator>Ohye, C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>199508</creationdate><title>Positron emission tomography with 4-[18F]fluoro-L-m-tyrosine in MPTP-induced hemiparkinsonian monkeys</title><author>Hayase, N ; Tomiyoshi, K ; Watanabe, K ; Horikoshi, S ; Shibasaki, T ; Ohye, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-5a67eacb1f463f28f3d7fd7b6fb191e42df1e8a426df3264be4a540b505eaeaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</topic><topic>Animals</topic><topic>Central Nervous System Stimulants - pharmacokinetics</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Corpus Striatum - metabolism</topic><topic>Fluorine Radioisotopes - pharmacokinetics</topic><topic>Macaca</topic><topic>Parkinson Disease, Secondary - chemically induced</topic><topic>Parkinson Disease, Secondary - diagnostic imaging</topic><topic>Parkinson Disease, Secondary - metabolism</topic><topic>Reference Values</topic><topic>Tomography, Emission-Computed - methods</topic><topic>Tyrosine - analogs & derivatives</topic><topic>Tyrosine - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayase, N</creatorcontrib><creatorcontrib>Tomiyoshi, K</creatorcontrib><creatorcontrib>Watanabe, K</creatorcontrib><creatorcontrib>Horikoshi, S</creatorcontrib><creatorcontrib>Shibasaki, T</creatorcontrib><creatorcontrib>Ohye, C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayase, N</au><au>Tomiyoshi, K</au><au>Watanabe, K</au><au>Horikoshi, S</au><au>Shibasaki, T</au><au>Ohye, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positron emission tomography with 4-[18F]fluoro-L-m-tyrosine in MPTP-induced hemiparkinsonian monkeys</atitle><jtitle>Annals of nuclear medicine</jtitle><addtitle>Ann Nucl Med</addtitle><date>1995-08</date><risdate>1995</risdate><volume>9</volume><issue>3</issue><spage>119</spage><epage>123</epage><pages>119-123</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>PET imaging studies with 4-[18F]fluoro-L-m-tyrosine (FMT) in normal macaca monkeys showed selective accumulations of radioactivity in the striatum with time. In monkeys rendered hemiparkinsonian by intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), FMT uptake was eliminated in the lesioned striatum. FMT-PET studies were able to detect dopaminergic terminals in both normal and hemiparkinsonian monkeys, and clearly showed a reduction in aromatic L-amino acid decarboxylase (AAAD) activities in the MPTP-lesioned striatum. These results show that FMT is promising as a PET tracer for the evaluation of central dopaminergic systems in parkinsonism.</abstract><cop>Japan</cop><pmid>8534583</pmid><doi>10.1007/BF03165037</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0914-7187 |
| ispartof | Annals of nuclear medicine, 1995-08, Vol.9 (3), p.119-123 |
| issn | 0914-7187 1864-6433 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Alma/SFX Local Collection |
| subjects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Central Nervous System Stimulants - pharmacokinetics Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Fluorine Radioisotopes - pharmacokinetics Macaca Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - diagnostic imaging Parkinson Disease, Secondary - metabolism Reference Values Tomography, Emission-Computed - methods Tyrosine - analogs & derivatives Tyrosine - pharmacokinetics |
| title | Positron emission tomography with 4-[18F]fluoro-L-m-tyrosine in MPTP-induced hemiparkinsonian monkeys |
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