Diabetes mellitus might be a protective factor of glioma
Aims: Several studies suggested that diabetes mellitus (DM) was associated with the risk of glioma. However, other studies did not confirm the result. Therefore, I conducted this meta-analysis. Materials and Methods: I retrieved the PubMed, Embase, and Web of Science database, by adopting keywords &...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2018-09, Vol.14 (10), p.644-647 |
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| description | Aims: Several studies suggested that diabetes mellitus (DM) was associated with the risk of glioma. However, other studies did not confirm the result. Therefore, I conducted this meta-analysis.
Materials and Methods: I retrieved the PubMed, Embase, and Web of Science database, by adopting keywords "glioma," and "diabetes," "DM." The strength of the associations between DM and the risk of glioma was measured by odds ratios (ORs) with 95% confidence intervals (95% CIs).
Results: Ten relevant studies were identified in the final analysis. A statistically significant association between DM and glioma risk was fond (OR = 0.84; 95% CI, 0.73-0.97; P = 0.02). In the subgroup analysis of age group, young population with DM showed decreased glioma risk (OR = 0.83; 95% CI, 0.70-0.98; P = 0.02), whereas old population with DM did not show a significant association (OR = 0.87; 95% CI, 0.65-1.16; P = 0.34). In the subgroup analysis of gender, male patients with DM showed decreased glioma risk (OR = 0.82; 95% CI, 0.68-0.99; P = 0.04), whereas female population with DM did not show a significant association (OR = 0.93; 95% CI, 0.70-1.24; P = 0.63).
Conclusions: This meta-analysis suggested that DM may be associated with the reduced glioma risk. |
| doi_str_mv | 10.4103/0973-1482.183184 |
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Materials and Methods: I retrieved the PubMed, Embase, and Web of Science database, by adopting keywords "glioma," and "diabetes," "DM." The strength of the associations between DM and the risk of glioma was measured by odds ratios (ORs) with 95% confidence intervals (95% CIs).
Results: Ten relevant studies were identified in the final analysis. A statistically significant association between DM and glioma risk was fond (OR = 0.84; 95% CI, 0.73-0.97; P = 0.02). In the subgroup analysis of age group, young population with DM showed decreased glioma risk (OR = 0.83; 95% CI, 0.70-0.98; P = 0.02), whereas old population with DM did not show a significant association (OR = 0.87; 95% CI, 0.65-1.16; P = 0.34). In the subgroup analysis of gender, male patients with DM showed decreased glioma risk (OR = 0.82; 95% CI, 0.68-0.99; P = 0.04), whereas female population with DM did not show a significant association (OR = 0.93; 95% CI, 0.70-1.24; P = 0.63).
Conclusions: This meta-analysis suggested that DM may be associated with the reduced glioma risk.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/0973-1482.183184</identifier><identifier>PMID: 30249881</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Autophagy ; Cancer ; Cell cycle ; Complications and side effects ; Diabetes ; Diabetes Complications - epidemiology ; Diabetes Complications - pathology ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Diabetes Mellitus - pathology ; Female ; Gender ; Glioma ; Glioma - complications ; Glioma - epidemiology ; Glioma - pathology ; Gliomas ; Humans ; Kinases ; Male ; Meta-analysis ; Middle Aged ; Mortality ; Protective Factors ; Quality ; Risk Factors ; Sex Characteristics ; Sex Factors ; Studies</subject><ispartof>Journal of cancer research and therapeutics, 2018-09, Vol.14 (10), p.644-647</ispartof><rights>COPYRIGHT 2018 Medknow Publications and Media Pvt. Ltd.</rights><rights>2018. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533s-d10de09334d052099a7e7e93b00d9b04ecc5c27e2c01c3b550d588c7b57fd0eb3</citedby><cites>FETCH-LOGICAL-c533s-d10de09334d052099a7e7e93b00d9b04ecc5c27e2c01c3b550d588c7b57fd0eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27435,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30249881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ni, Ting-Ting</creatorcontrib><title>Diabetes mellitus might be a protective factor of glioma</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Aims: Several studies suggested that diabetes mellitus (DM) was associated with the risk of glioma. However, other studies did not confirm the result. Therefore, I conducted this meta-analysis.
Materials and Methods: I retrieved the PubMed, Embase, and Web of Science database, by adopting keywords "glioma," and "diabetes," "DM." The strength of the associations between DM and the risk of glioma was measured by odds ratios (ORs) with 95% confidence intervals (95% CIs).
Results: Ten relevant studies were identified in the final analysis. A statistically significant association between DM and glioma risk was fond (OR = 0.84; 95% CI, 0.73-0.97; P = 0.02). In the subgroup analysis of age group, young population with DM showed decreased glioma risk (OR = 0.83; 95% CI, 0.70-0.98; P = 0.02), whereas old population with DM did not show a significant association (OR = 0.87; 95% CI, 0.65-1.16; P = 0.34). In the subgroup analysis of gender, male patients with DM showed decreased glioma risk (OR = 0.82; 95% CI, 0.68-0.99; P = 0.04), whereas female population with DM did not show a significant association (OR = 0.93; 95% CI, 0.70-1.24; P = 0.63).
Conclusions: This meta-analysis suggested that DM may be associated with the reduced glioma risk.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Autophagy</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes Complications - epidemiology</subject><subject>Diabetes Complications - pathology</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes Mellitus - pathology</subject><subject>Female</subject><subject>Gender</subject><subject>Glioma</subject><subject>Glioma - complications</subject><subject>Glioma - epidemiology</subject><subject>Glioma - pathology</subject><subject>Gliomas</subject><subject>Humans</subject><subject>Kinases</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Protective Factors</subject><subject>Quality</subject><subject>Risk Factors</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><subject>Studies</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks1vFCEYxonR2LV692Qm8eJl1pevAsda60fSxIueCcO8s9LODBUYN_73Zd12Y82GAwR-z5MHHgh5TWEtKPD3YBRvqdBsTTWnWjwhK2qMbgXl-ilZHY5PyIucrwGkYkw_JyccmDBa0xXRH4PrsGBuJhzHUJa6CJufpemwcc1tigV9Cb-xGZwvMTVxaDZjiJN7SZ4Nbsz46n4-JT8-XX6_-NJeffv89eL8qvWS89z2FHoEw7noQTIwxilUaHgH0JsOBHovPVPIPFDPOymhl1p71Uk19IAdPyXv9r41y68Fc7FTyL5mdTPGJVtGKaOGS2Mq-vY_9Douaa7p_lKgtKoPc6A2bkQb5iGW5PzO1J5LKc-4EVxXqj1CbXDG5MY44xDq9iN-fYSvo8cp-KMC2At8ijknHOxtCpNLfywFuyvX7tqzu_bsvtwqeXN_v6WbsD8IHtqswIc9sI1jwZRvxmWLyVb2Zo7bR8btP8b2TAj78A_4HVpssAI</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Ni, Ting-Ting</creator><general>Wolters Kluwer India Pvt. 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However, other studies did not confirm the result. Therefore, I conducted this meta-analysis.
Materials and Methods: I retrieved the PubMed, Embase, and Web of Science database, by adopting keywords "glioma," and "diabetes," "DM." The strength of the associations between DM and the risk of glioma was measured by odds ratios (ORs) with 95% confidence intervals (95% CIs).
Results: Ten relevant studies were identified in the final analysis. A statistically significant association between DM and glioma risk was fond (OR = 0.84; 95% CI, 0.73-0.97; P = 0.02). In the subgroup analysis of age group, young population with DM showed decreased glioma risk (OR = 0.83; 95% CI, 0.70-0.98; P = 0.02), whereas old population with DM did not show a significant association (OR = 0.87; 95% CI, 0.65-1.16; P = 0.34). In the subgroup analysis of gender, male patients with DM showed decreased glioma risk (OR = 0.82; 95% CI, 0.68-0.99; P = 0.04), whereas female population with DM did not show a significant association (OR = 0.93; 95% CI, 0.70-1.24; P = 0.63).
Conclusions: This meta-analysis suggested that DM may be associated with the reduced glioma risk.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>30249881</pmid><doi>10.4103/0973-1482.183184</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Age Factors Aged Autophagy Cancer Cell cycle Complications and side effects Diabetes Diabetes Complications - epidemiology Diabetes Complications - pathology Diabetes mellitus Diabetes Mellitus - epidemiology Diabetes Mellitus - pathology Female Gender Glioma Glioma - complications Glioma - epidemiology Glioma - pathology Gliomas Humans Kinases Male Meta-analysis Middle Aged Mortality Protective Factors Quality Risk Factors Sex Characteristics Sex Factors Studies |
| title | Diabetes mellitus might be a protective factor of glioma |
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