Half-life of alpha-fetoprotein in neonatal sacrococcygeal teratoma
Alpha-fetoprotein (AFP) is useful as a tumor marker for sacrococcygeal teratoma (SCT). We investigated the half-life of AFP in SCT. Neonates who underwent surgical treatment for SCT between 1997 and 2016 were included in the study, whereas patients who died before or after surgery or had malignant g...
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric surgery 2018-12, Vol.53 (12), p.2470-2474 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2474 |
|---|---|
| container_issue | 12 |
| container_start_page | 2470 |
| container_title | Journal of pediatric surgery |
| container_volume | 53 |
| creator | Nam, So Hyun Cho, Min Jeng Kim, Dae Yeon Kim, Seong Chul |
| description | Alpha-fetoprotein (AFP) is useful as a tumor marker for sacrococcygeal teratoma (SCT). We investigated the half-life of AFP in SCT.
Neonates who underwent surgical treatment for SCT between 1997 and 2016 were included in the study, whereas patients who died before or after surgery or had malignant germ cell tumors were excluded.
Fifty-five non-recurrent SCT patients (M:F = 18:37) were enrolled. They underwent surgery on average 7.4 ± 4.1 days after birth. Serum AFP was measured an average 4.25 ± 2.07 times per patient. We obtained 165 half-lives following the formula (M = Mo * (1/2) Δt/T). A positive correlation was observed between half-life and patient age using the formula T1/2 = 0.0597 × days +6.1643 (p |
| doi_str_mv | 10.1016/j.jpedsurg.2018.08.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2112192547</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022346818305189</els_id><sourcerecordid>2112192547</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-8a013af31b76623cbfe34c22e601a2483146b63c43680ee35034c32b2bb4d6723</originalsourceid><addsrcrecordid>eNqFkF9LwzAUxYMobk6_wuijL625SZp2b-pQJwx80eeQprczpf9MWsFvb8Y2X4UDIZdfcs49hCyBJkBB3tVJPWDpJ7dLGIU8oUHAzsgcUg5xSnl2TuaUMhZzIfMZufK-pjSMKVySGadMrHi6mpPHjW6quLEVRn0V6Wb41HGFYz-4fkTbRUEd9p0edRN5bVxvemN-dhiuIzo99q2-JheVbjzeHM8F-Xh-el9v4u3by-v6YRsbLvMxzjUFrisORSYl46aokAvDGEoKmomcg5CF5EYEmiLysIMwnBWsKEQpM8YX5Pbwb8j2NaEfVWu9wabRIeHkFQNgsGKpyAIqD2gI7L3DSg3Ottr9KKBq35-q1ak_te9P0SDYeyyPHlPRYvn37FRYAO4PAIZNvy065Y3FzmBpHZpRlb39z-MXz2SD7w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2112192547</pqid></control><display><type>article</type><title>Half-life of alpha-fetoprotein in neonatal sacrococcygeal teratoma</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Nam, So Hyun ; Cho, Min Jeng ; Kim, Dae Yeon ; Kim, Seong Chul</creator><creatorcontrib>Nam, So Hyun ; Cho, Min Jeng ; Kim, Dae Yeon ; Kim, Seong Chul</creatorcontrib><description>Alpha-fetoprotein (AFP) is useful as a tumor marker for sacrococcygeal teratoma (SCT). We investigated the half-life of AFP in SCT.
Neonates who underwent surgical treatment for SCT between 1997 and 2016 were included in the study, whereas patients who died before or after surgery or had malignant germ cell tumors were excluded.
Fifty-five non-recurrent SCT patients (M:F = 18:37) were enrolled. They underwent surgery on average 7.4 ± 4.1 days after birth. Serum AFP was measured an average 4.25 ± 2.07 times per patient. We obtained 165 half-lives following the formula (M = Mo * (1/2) Δt/T). A positive correlation was observed between half-life and patient age using the formula T1/2 = 0.0597 × days +6.1643 (p < 0.001). It was different from recurrent SCT (T1/2 = 0.1196 × days −0.0633) (p < 0.05). Half-life was different between mature SCT (T1/2 = 0.0671 × days +4.3912) and immature SCT (T1/2 = 0.0433 × days +8.9339) (p < 0.05).
The half-life of AFP in neonatal patients with SCT was prolonged in proportion to the age, and it was getting longer in recurrent tumor than non-recurrent tumor. The half-life of AFP was longer in immature teratoma than in mature teratoma.
IV.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/j.jpedsurg.2018.08.012</identifier><identifier>PMID: 30249359</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alpha-fetoprotein ; alpha-Fetoproteins - analysis ; Biomarkers, Tumor - blood ; Female ; Half-Life ; Humans ; Infant, Newborn ; Male ; Neoplasm Recurrence, Local - blood ; Neoplasm Recurrence, Local - pathology ; Retrospective Studies ; Sacrococcygeal Region - pathology ; Sacrococcygeal teratoma ; Teratoma - blood ; Teratoma - surgery ; Tumor marker</subject><ispartof>Journal of pediatric surgery, 2018-12, Vol.53 (12), p.2470-2474</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-8a013af31b76623cbfe34c22e601a2483146b63c43680ee35034c32b2bb4d6723</citedby><cites>FETCH-LOGICAL-c368t-8a013af31b76623cbfe34c22e601a2483146b63c43680ee35034c32b2bb4d6723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpedsurg.2018.08.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30249359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nam, So Hyun</creatorcontrib><creatorcontrib>Cho, Min Jeng</creatorcontrib><creatorcontrib>Kim, Dae Yeon</creatorcontrib><creatorcontrib>Kim, Seong Chul</creatorcontrib><title>Half-life of alpha-fetoprotein in neonatal sacrococcygeal teratoma</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>Alpha-fetoprotein (AFP) is useful as a tumor marker for sacrococcygeal teratoma (SCT). We investigated the half-life of AFP in SCT.
Neonates who underwent surgical treatment for SCT between 1997 and 2016 were included in the study, whereas patients who died before or after surgery or had malignant germ cell tumors were excluded.
Fifty-five non-recurrent SCT patients (M:F = 18:37) were enrolled. They underwent surgery on average 7.4 ± 4.1 days after birth. Serum AFP was measured an average 4.25 ± 2.07 times per patient. We obtained 165 half-lives following the formula (M = Mo * (1/2) Δt/T). A positive correlation was observed between half-life and patient age using the formula T1/2 = 0.0597 × days +6.1643 (p < 0.001). It was different from recurrent SCT (T1/2 = 0.1196 × days −0.0633) (p < 0.05). Half-life was different between mature SCT (T1/2 = 0.0671 × days +4.3912) and immature SCT (T1/2 = 0.0433 × days +8.9339) (p < 0.05).
The half-life of AFP in neonatal patients with SCT was prolonged in proportion to the age, and it was getting longer in recurrent tumor than non-recurrent tumor. The half-life of AFP was longer in immature teratoma than in mature teratoma.
IV.</description><subject>Alpha-fetoprotein</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Biomarkers, Tumor - blood</subject><subject>Female</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Neoplasm Recurrence, Local - blood</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Retrospective Studies</subject><subject>Sacrococcygeal Region - pathology</subject><subject>Sacrococcygeal teratoma</subject><subject>Teratoma - blood</subject><subject>Teratoma - surgery</subject><subject>Tumor marker</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF9LwzAUxYMobk6_wuijL625SZp2b-pQJwx80eeQprczpf9MWsFvb8Y2X4UDIZdfcs49hCyBJkBB3tVJPWDpJ7dLGIU8oUHAzsgcUg5xSnl2TuaUMhZzIfMZufK-pjSMKVySGadMrHi6mpPHjW6quLEVRn0V6Wb41HGFYz-4fkTbRUEd9p0edRN5bVxvemN-dhiuIzo99q2-JheVbjzeHM8F-Xh-el9v4u3by-v6YRsbLvMxzjUFrisORSYl46aokAvDGEoKmomcg5CF5EYEmiLysIMwnBWsKEQpM8YX5Pbwb8j2NaEfVWu9wabRIeHkFQNgsGKpyAIqD2gI7L3DSg3Ottr9KKBq35-q1ak_te9P0SDYeyyPHlPRYvn37FRYAO4PAIZNvy065Y3FzmBpHZpRlb39z-MXz2SD7w</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Nam, So Hyun</creator><creator>Cho, Min Jeng</creator><creator>Kim, Dae Yeon</creator><creator>Kim, Seong Chul</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>Half-life of alpha-fetoprotein in neonatal sacrococcygeal teratoma</title><author>Nam, So Hyun ; Cho, Min Jeng ; Kim, Dae Yeon ; Kim, Seong Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-8a013af31b76623cbfe34c22e601a2483146b63c43680ee35034c32b2bb4d6723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alpha-fetoprotein</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Biomarkers, Tumor - blood</topic><topic>Female</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Neoplasm Recurrence, Local - blood</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Retrospective Studies</topic><topic>Sacrococcygeal Region - pathology</topic><topic>Sacrococcygeal teratoma</topic><topic>Teratoma - blood</topic><topic>Teratoma - surgery</topic><topic>Tumor marker</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nam, So Hyun</creatorcontrib><creatorcontrib>Cho, Min Jeng</creatorcontrib><creatorcontrib>Kim, Dae Yeon</creatorcontrib><creatorcontrib>Kim, Seong Chul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nam, So Hyun</au><au>Cho, Min Jeng</au><au>Kim, Dae Yeon</au><au>Kim, Seong Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Half-life of alpha-fetoprotein in neonatal sacrococcygeal teratoma</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>2018-12</date><risdate>2018</risdate><volume>53</volume><issue>12</issue><spage>2470</spage><epage>2474</epage><pages>2470-2474</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><abstract>Alpha-fetoprotein (AFP) is useful as a tumor marker for sacrococcygeal teratoma (SCT). We investigated the half-life of AFP in SCT.
Neonates who underwent surgical treatment for SCT between 1997 and 2016 were included in the study, whereas patients who died before or after surgery or had malignant germ cell tumors were excluded.
Fifty-five non-recurrent SCT patients (M:F = 18:37) were enrolled. They underwent surgery on average 7.4 ± 4.1 days after birth. Serum AFP was measured an average 4.25 ± 2.07 times per patient. We obtained 165 half-lives following the formula (M = Mo * (1/2) Δt/T). A positive correlation was observed between half-life and patient age using the formula T1/2 = 0.0597 × days +6.1643 (p < 0.001). It was different from recurrent SCT (T1/2 = 0.1196 × days −0.0633) (p < 0.05). Half-life was different between mature SCT (T1/2 = 0.0671 × days +4.3912) and immature SCT (T1/2 = 0.0433 × days +8.9339) (p < 0.05).
The half-life of AFP in neonatal patients with SCT was prolonged in proportion to the age, and it was getting longer in recurrent tumor than non-recurrent tumor. The half-life of AFP was longer in immature teratoma than in mature teratoma.
IV.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30249359</pmid><doi>10.1016/j.jpedsurg.2018.08.012</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3468 |
| ispartof | Journal of pediatric surgery, 2018-12, Vol.53 (12), p.2470-2474 |
| issn | 0022-3468 1531-5037 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2112192547 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alpha-fetoprotein alpha-Fetoproteins - analysis Biomarkers, Tumor - blood Female Half-Life Humans Infant, Newborn Male Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - pathology Retrospective Studies Sacrococcygeal Region - pathology Sacrococcygeal teratoma Teratoma - blood Teratoma - surgery Tumor marker |
| title | Half-life of alpha-fetoprotein in neonatal sacrococcygeal teratoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T20%3A48%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Half-life%20of%20alpha-fetoprotein%20in%20neonatal%20sacrococcygeal%20teratoma&rft.jtitle=Journal%20of%20pediatric%20surgery&rft.au=Nam,%20So%20Hyun&rft.date=2018-12&rft.volume=53&rft.issue=12&rft.spage=2470&rft.epage=2474&rft.pages=2470-2474&rft.issn=0022-3468&rft.eissn=1531-5037&rft_id=info:doi/10.1016/j.jpedsurg.2018.08.012&rft_dat=%3Cproquest_cross%3E2112192547%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2112192547&rft_id=info:pmid/30249359&rft_els_id=S0022346818305189&rfr_iscdi=true |