METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition

As the most prevalent internal modification in mammalian messenger RNA, N6‑methyladenosine (m6A) plays an important role in posttranscriptional gene regulation. METTL3 is a key component of the m6A methyltransferase complex and has recently been shown to play important roles in cancer development an...

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Veröffentlicht in:	Gynecologic oncology 2018-11, Vol.151 (2), p.356-365
Hauptverfasser:	Hua, Wenfeng, Zhao, Yuan, Jin, Xiaohan, Yu, Danyang, He, Jing, Xie, Dan, Duan, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AXL Cell Growth Processes - physiology Cell Line, Tumor Cell Movement - physiology EMT Epithelial-Mesenchymal Transition Female Gene Knockdown Techniques Heterografts Humans Methyltransferases - biosynthesis Methyltransferases - genetics Methyltransferases - metabolism METTL3 Mice Mice, Inbred BALB C Mice, Nude Middle Aged N6‑methyladenosine Neoplasm Invasiveness Ovarian cancer Ovarian Neoplasms - enzymology Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Up-Regulation
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