sRANKL and its correlation with metabolic syndrome parameters in children
Background Activating receptor ligand for nuclear factor (RANKL) has been identified as a ligand attached to the cell membrane of osteoblasts and odontoclasts. Aim To determine a possible association of sRANKL in saliva and serum with the parameters of metabolic syndrome (MS) in paediatric populatio...
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| Veröffentlicht in: | International journal of paediatric dentistry 2018-11, Vol.28 (6), p.633-640 |
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| container_title | International journal of paediatric dentistry |
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| creator | Serrano‐Piña, Rodrigo Trujillo‐Güiza, Martha Liliana Scougall Vilchis, Rogelio J. Layton‐Tovar, Cristian F. Mendieta‐Zerón, Hugo |
| description | Background
Activating receptor ligand for nuclear factor (RANKL) has been identified as a ligand attached to the cell membrane of osteoblasts and odontoclasts.
Aim
To determine a possible association of sRANKL in saliva and serum with the parameters of metabolic syndrome (MS) in paediatric population aged 8‐12 years.
Design
This was a clinical, analytical and comparative study. Students between 6 and 12 years with good oral hygiene were included. Anthropometry, clinical analysis, dentobacterial plaque registration were registered as well as sRANKL in total saliva and serum through the ELISA technique.
Results
A total of 43 children were enrolled, with a mean age of 9.7 (±0.8 years). Contrasting the groups by the presence or absence of the waist circumference above the normal limit, the difference in serum sRANKL concentration was statistically significant (P ≤ 0.05). A negative statistical significance was found in the correlation between serum sRANKL and HDLc (r2 = −0.310, P = 0.046). Saliva sRANKL did not show statistical difference between neither gender nor body mass index and was not correlated with any parameter of the MS.
Conclusions
A good oral hygiene seems to avoid the effects of MS on the oral cavity. |
| doi_str_mv | 10.1111/ipd.12422 |
| format | Article |
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Activating receptor ligand for nuclear factor (RANKL) has been identified as a ligand attached to the cell membrane of osteoblasts and odontoclasts.
Aim
To determine a possible association of sRANKL in saliva and serum with the parameters of metabolic syndrome (MS) in paediatric population aged 8‐12 years.
Design
This was a clinical, analytical and comparative study. Students between 6 and 12 years with good oral hygiene were included. Anthropometry, clinical analysis, dentobacterial plaque registration were registered as well as sRANKL in total saliva and serum through the ELISA technique.
Results
A total of 43 children were enrolled, with a mean age of 9.7 (±0.8 years). Contrasting the groups by the presence or absence of the waist circumference above the normal limit, the difference in serum sRANKL concentration was statistically significant (P ≤ 0.05). A negative statistical significance was found in the correlation between serum sRANKL and HDLc (r2 = −0.310, P = 0.046). Saliva sRANKL did not show statistical difference between neither gender nor body mass index and was not correlated with any parameter of the MS.
Conclusions
A good oral hygiene seems to avoid the effects of MS on the oral cavity.</description><identifier>ISSN: 0960-7439</identifier><identifier>EISSN: 1365-263X</identifier><identifier>DOI: 10.1111/ipd.12422</identifier><identifier>PMID: 30252176</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Anthropometry ; Biomarkers - blood ; Blood Glucose ; Blood Pressure ; Body Mass Index ; Cell membranes ; Child ; Children ; Cholesterol, HDL - blood ; Dentistry ; Enzyme-linked immunosorbent assay ; Female ; Humans ; Leptin - blood ; Ligands ; Male ; Metabolic syndrome ; Metabolic Syndrome - blood ; Mexico ; Obesity ; Odontoclasts ; Oral cavity ; Oral Health ; Oral Hygiene ; Osteoblasts ; RANK Ligand - blood ; Saliva ; Saliva - chemistry ; sRANKL ; Statistical analysis ; Statistics ; TRANCE protein ; Triglycerides - blood</subject><ispartof>International journal of paediatric dentistry, 2018-11, Vol.28 (6), p.633-640</ispartof><rights>2018 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2018 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>International Journal of Paediatric Dentistry © 2018 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-4ce0f9c2628258344bd0697da55adcdff01d2b8ee065a2e3030520ae1bb6ac113</citedby><cites>FETCH-LOGICAL-c3532-4ce0f9c2628258344bd0697da55adcdff01d2b8ee065a2e3030520ae1bb6ac113</cites><orcidid>0000-0003-3492-8950</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fipd.12422$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fipd.12422$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30252176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serrano‐Piña, Rodrigo</creatorcontrib><creatorcontrib>Trujillo‐Güiza, Martha Liliana</creatorcontrib><creatorcontrib>Scougall Vilchis, Rogelio J.</creatorcontrib><creatorcontrib>Layton‐Tovar, Cristian F.</creatorcontrib><creatorcontrib>Mendieta‐Zerón, Hugo</creatorcontrib><title>sRANKL and its correlation with metabolic syndrome parameters in children</title><title>International journal of paediatric dentistry</title><addtitle>Int J Paediatr Dent</addtitle><description>Background
Activating receptor ligand for nuclear factor (RANKL) has been identified as a ligand attached to the cell membrane of osteoblasts and odontoclasts.
Aim
To determine a possible association of sRANKL in saliva and serum with the parameters of metabolic syndrome (MS) in paediatric population aged 8‐12 years.
Design
This was a clinical, analytical and comparative study. Students between 6 and 12 years with good oral hygiene were included. Anthropometry, clinical analysis, dentobacterial plaque registration were registered as well as sRANKL in total saliva and serum through the ELISA technique.
Results
A total of 43 children were enrolled, with a mean age of 9.7 (±0.8 years). Contrasting the groups by the presence or absence of the waist circumference above the normal limit, the difference in serum sRANKL concentration was statistically significant (P ≤ 0.05). A negative statistical significance was found in the correlation between serum sRANKL and HDLc (r2 = −0.310, P = 0.046). Saliva sRANKL did not show statistical difference between neither gender nor body mass index and was not correlated with any parameter of the MS.
Conclusions
A good oral hygiene seems to avoid the effects of MS on the oral cavity.</description><subject>Anthropometry</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cell membranes</subject><subject>Child</subject><subject>Children</subject><subject>Cholesterol, HDL - blood</subject><subject>Dentistry</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Ligands</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Mexico</subject><subject>Obesity</subject><subject>Odontoclasts</subject><subject>Oral cavity</subject><subject>Oral Health</subject><subject>Oral Hygiene</subject><subject>Osteoblasts</subject><subject>RANK Ligand - blood</subject><subject>Saliva</subject><subject>Saliva - chemistry</subject><subject>sRANKL</subject><subject>Statistical analysis</subject><subject>Statistics</subject><subject>TRANCE protein</subject><subject>Triglycerides - blood</subject><issn>0960-7439</issn><issn>1365-263X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LJDEQBuAgK-v4cfAPSGAv66GdSqWT7j7KrB-Dg4rsgrcmnVRjpD_GpAeZf2-P43oQrEtB8fBSvIwdCzgT40z90p0JTBF32ERIrRLU8vEHm0ChIclSWeyx_RifAYQChJ9sTwIqFJmesHl8OL-9WXDTOe6HyG0fAjVm8H3HX_3wxFsaTNU33vK47lzoW-JLE8x4phC577h98o0L1B2y3do0kY4-9gH7d3nxd3adLO6u5rPzRWKlkpiklqAuLGrMUeUyTSsHusicUco46-oahMMqJwKtDJIECQrBkKgqbawQ8oD93uYuQ_-yojiUrY-WmsZ01K9iiUKgKEBmONJfX-hzvwrd-N1GFVrlucxGdbpVNvQxBqrLZfCtCetSQLnptxz7Ld_7He3JR-Kqasl9yv-FjmC6Ba--ofX3SeX8_s828g1JEoMG</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Serrano‐Piña, Rodrigo</creator><creator>Trujillo‐Güiza, Martha Liliana</creator><creator>Scougall Vilchis, Rogelio J.</creator><creator>Layton‐Tovar, Cristian F.</creator><creator>Mendieta‐Zerón, Hugo</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3492-8950</orcidid></search><sort><creationdate>201811</creationdate><title>sRANKL and its correlation with metabolic syndrome parameters in children</title><author>Serrano‐Piña, Rodrigo ; Trujillo‐Güiza, Martha Liliana ; Scougall Vilchis, Rogelio J. ; Layton‐Tovar, Cristian F. ; Mendieta‐Zerón, Hugo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-4ce0f9c2628258344bd0697da55adcdff01d2b8ee065a2e3030520ae1bb6ac113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anthropometry</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cell membranes</topic><topic>Child</topic><topic>Children</topic><topic>Cholesterol, HDL - blood</topic><topic>Dentistry</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Humans</topic><topic>Leptin - blood</topic><topic>Ligands</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Mexico</topic><topic>Obesity</topic><topic>Odontoclasts</topic><topic>Oral cavity</topic><topic>Oral Health</topic><topic>Oral Hygiene</topic><topic>Osteoblasts</topic><topic>RANK Ligand - blood</topic><topic>Saliva</topic><topic>Saliva - chemistry</topic><topic>sRANKL</topic><topic>Statistical analysis</topic><topic>Statistics</topic><topic>TRANCE protein</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serrano‐Piña, Rodrigo</creatorcontrib><creatorcontrib>Trujillo‐Güiza, Martha Liliana</creatorcontrib><creatorcontrib>Scougall Vilchis, Rogelio J.</creatorcontrib><creatorcontrib>Layton‐Tovar, Cristian F.</creatorcontrib><creatorcontrib>Mendieta‐Zerón, Hugo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of paediatric dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serrano‐Piña, Rodrigo</au><au>Trujillo‐Güiza, Martha Liliana</au><au>Scougall Vilchis, Rogelio J.</au><au>Layton‐Tovar, Cristian F.</au><au>Mendieta‐Zerón, Hugo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>sRANKL and its correlation with metabolic syndrome parameters in children</atitle><jtitle>International journal of paediatric dentistry</jtitle><addtitle>Int J Paediatr Dent</addtitle><date>2018-11</date><risdate>2018</risdate><volume>28</volume><issue>6</issue><spage>633</spage><epage>640</epage><pages>633-640</pages><issn>0960-7439</issn><eissn>1365-263X</eissn><abstract>Background
Activating receptor ligand for nuclear factor (RANKL) has been identified as a ligand attached to the cell membrane of osteoblasts and odontoclasts.
Aim
To determine a possible association of sRANKL in saliva and serum with the parameters of metabolic syndrome (MS) in paediatric population aged 8‐12 years.
Design
This was a clinical, analytical and comparative study. Students between 6 and 12 years with good oral hygiene were included. Anthropometry, clinical analysis, dentobacterial plaque registration were registered as well as sRANKL in total saliva and serum through the ELISA technique.
Results
A total of 43 children were enrolled, with a mean age of 9.7 (±0.8 years). Contrasting the groups by the presence or absence of the waist circumference above the normal limit, the difference in serum sRANKL concentration was statistically significant (P ≤ 0.05). A negative statistical significance was found in the correlation between serum sRANKL and HDLc (r2 = −0.310, P = 0.046). Saliva sRANKL did not show statistical difference between neither gender nor body mass index and was not correlated with any parameter of the MS.
Conclusions
A good oral hygiene seems to avoid the effects of MS on the oral cavity.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>30252176</pmid><doi>10.1111/ipd.12422</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3492-8950</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of paediatric dentistry, 2018-11, Vol.28 (6), p.633-640 |
| issn | 0960-7439 1365-263X |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Anthropometry Biomarkers - blood Blood Glucose Blood Pressure Body Mass Index Cell membranes Child Children Cholesterol, HDL - blood Dentistry Enzyme-linked immunosorbent assay Female Humans Leptin - blood Ligands Male Metabolic syndrome Metabolic Syndrome - blood Mexico Obesity Odontoclasts Oral cavity Oral Health Oral Hygiene Osteoblasts RANK Ligand - blood Saliva Saliva - chemistry sRANKL Statistical analysis Statistics TRANCE protein Triglycerides - blood |
| title | sRANKL and its correlation with metabolic syndrome parameters in children |
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