The impact of epilepsy duration in a series of patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis
•Lower hippocampal cell density correlates to a longer epilepsy duration.•Thinning and dispersion of the granular cells are related to longer epilepsy duration.•Lower ipsilateral hippocampal volume is associated with a longer epilepsy duration.•Ipsilateral hippocampal volume correlates to the estima...
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| Veröffentlicht in: | Epilepsy research 2018-11, Vol.147, p.51-57 |
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| creator | Duarte, Jeana Torres Corso Jardim, Anaclara Prada Comper, Sandra Mara De Marchi, Luciana Rodrigues Gaça, Larissa Botelho Garcia, Maria Teresa Fernandes Castilho Sandim, Gabriel Barbosa Assunção-Leme, Idaiane Batista Carrete, Henrique Centeno, Ricardo Silva Lancellotti, Carmen Lúcia Penteado Jackowski, Andrea P. Cavalheiro, Esper Abrão Guaranha, Mirian Salvadori Bittar Yacubian, Elza Márcia Targas |
| description | •Lower hippocampal cell density correlates to a longer epilepsy duration.•Thinning and dispersion of the granular cells are related to longer epilepsy duration.•Lower ipsilateral hippocampal volume is associated with a longer epilepsy duration.•Ipsilateral hippocampal volume correlates to the estimated hippocampal cell density.
To evaluate if the duration of epilepsy influences MRI volumes of the hippocampus, amygdala, parahippocampal gyrus, entorhinal cortex and temporal pole of both hemispheres and epileptogenic hippocampus neuronal cell density and dentate gyrus granular cells distribution in patients with refractory mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS).
Seventy-seven patients with refractory MTLE/HS submitted to surgery were included. Histopathological analysis included: (1) quantitative: hippocampal subfields and total estimated hippocampal cell density (HCD), thickness of the dentate gyrus – normal, thinning or dispersion; (2) qualitative: type of HS and granule cells pathology in the dentate gyrus (normal, neuronal cell loss, dispersion and bilamination). Automated MRI-derived measurements from bilateral temporal structures (hippocampus, amygdala, parahippocampal gyrus, temporal pole, entorhinal cortex) were obtained for 58 subjects. Histopathological and imaging findings were compared with data from specimens obtained in autopsies of age-matched individuals and living controls, respectively, and the data were adjusted for the age at epilepsy onset and the frequency of focal impaired awareness seizures/month.
Forty-two (54.5%) patients presented right HS. The greater the duration of epilepsy, the smaller the total estimated HCD (p = 0.025; r = −0.259). Patients with a normal distribution of the granular cells had a shorter epilepsy duration than those with dispersion (p = 0.018) or thinning (p = 0.031). A reduced ipsilateral hippocampal volume (r = −0.551, p = 0.017) and a smaller hippocampal asymmetry index (r = −0.414, p = 0.002) were correlated to a longer epilepsy duration. The estimated HCD was correlated to the volume of the ipsilateral hippocampus (r = 0.420, p = 0.001).
Our study showed an increasing atrophy of the ipsilateral hippocampus in patients with a longer epilepsy duration. Our data suggest that this reduction in hippocampal volume is related to neuronal loss. Besides that, we also showed an increased probability of exhibiting an abnormal distribution of the granular cells in the dentate gyrus in pati |
| doi_str_mv | 10.1016/j.eplepsyres.2018.08.009 |
| format | Article |
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To evaluate if the duration of epilepsy influences MRI volumes of the hippocampus, amygdala, parahippocampal gyrus, entorhinal cortex and temporal pole of both hemispheres and epileptogenic hippocampus neuronal cell density and dentate gyrus granular cells distribution in patients with refractory mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS).
Seventy-seven patients with refractory MTLE/HS submitted to surgery were included. Histopathological analysis included: (1) quantitative: hippocampal subfields and total estimated hippocampal cell density (HCD), thickness of the dentate gyrus – normal, thinning or dispersion; (2) qualitative: type of HS and granule cells pathology in the dentate gyrus (normal, neuronal cell loss, dispersion and bilamination). Automated MRI-derived measurements from bilateral temporal structures (hippocampus, amygdala, parahippocampal gyrus, temporal pole, entorhinal cortex) were obtained for 58 subjects. Histopathological and imaging findings were compared with data from specimens obtained in autopsies of age-matched individuals and living controls, respectively, and the data were adjusted for the age at epilepsy onset and the frequency of focal impaired awareness seizures/month.
Forty-two (54.5%) patients presented right HS. The greater the duration of epilepsy, the smaller the total estimated HCD (p = 0.025; r = −0.259). Patients with a normal distribution of the granular cells had a shorter epilepsy duration than those with dispersion (p = 0.018) or thinning (p = 0.031). A reduced ipsilateral hippocampal volume (r = −0.551, p = 0.017) and a smaller hippocampal asymmetry index (r = −0.414, p = 0.002) were correlated to a longer epilepsy duration. The estimated HCD was correlated to the volume of the ipsilateral hippocampus (r = 0.420, p = 0.001).
Our study showed an increasing atrophy of the ipsilateral hippocampus in patients with a longer epilepsy duration. Our data suggest that this reduction in hippocampal volume is related to neuronal loss. Besides that, we also showed an increased probability of exhibiting an abnormal distribution of the granular cells in the dentate gyrus in patients with longer epilepsy duration.</description><identifier>ISSN: 0920-1211</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/j.eplepsyres.2018.08.009</identifier><identifier>PMID: 30248630</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Brain - diagnostic imaging ; Brain - pathology ; Brain Mapping ; Cell Count ; Epilepsy, Temporal Lobe - complications ; Epilepsy, Temporal Lobe - pathology ; Female ; FreeSurfer volumetry ; Hippocampal sclerosis ; Hippocampus - diagnostic imaging ; Hippocampus - pathology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Mesial temporal lobe epilepsy ; Middle Aged ; Neurons - metabolism ; Neurons - pathology ; Phosphopyruvate Hydratase - metabolism ; Sclerosis - diagnostic imaging ; Sclerosis - pathology ; Young Adult</subject><ispartof>Epilepsy research, 2018-11, Vol.147, p.51-57</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c289t-fd256814dc41c16e07e01bca0e617dcebf5d04526a8a6349e1034c5034b7b0f3</citedby><cites>FETCH-LOGICAL-c289t-fd256814dc41c16e07e01bca0e617dcebf5d04526a8a6349e1034c5034b7b0f3</cites><orcidid>0000-0003-1016-7624 ; 0000-0003-0654-9283</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0920121117304138$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30248630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duarte, Jeana Torres Corso</creatorcontrib><creatorcontrib>Jardim, Anaclara Prada</creatorcontrib><creatorcontrib>Comper, Sandra Mara</creatorcontrib><creatorcontrib>De Marchi, Luciana Rodrigues</creatorcontrib><creatorcontrib>Gaça, Larissa Botelho</creatorcontrib><creatorcontrib>Garcia, Maria Teresa Fernandes Castilho</creatorcontrib><creatorcontrib>Sandim, Gabriel Barbosa</creatorcontrib><creatorcontrib>Assunção-Leme, Idaiane Batista</creatorcontrib><creatorcontrib>Carrete, Henrique</creatorcontrib><creatorcontrib>Centeno, Ricardo Silva</creatorcontrib><creatorcontrib>Lancellotti, Carmen Lúcia Penteado</creatorcontrib><creatorcontrib>Jackowski, Andrea P.</creatorcontrib><creatorcontrib>Cavalheiro, Esper Abrão</creatorcontrib><creatorcontrib>Guaranha, Mirian Salvadori Bittar</creatorcontrib><creatorcontrib>Yacubian, Elza Márcia Targas</creatorcontrib><title>The impact of epilepsy duration in a series of patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis</title><title>Epilepsy research</title><addtitle>Epilepsy Res</addtitle><description>•Lower hippocampal cell density correlates to a longer epilepsy duration.•Thinning and dispersion of the granular cells are related to longer epilepsy duration.•Lower ipsilateral hippocampal volume is associated with a longer epilepsy duration.•Ipsilateral hippocampal volume correlates to the estimated hippocampal cell density.
To evaluate if the duration of epilepsy influences MRI volumes of the hippocampus, amygdala, parahippocampal gyrus, entorhinal cortex and temporal pole of both hemispheres and epileptogenic hippocampus neuronal cell density and dentate gyrus granular cells distribution in patients with refractory mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS).
Seventy-seven patients with refractory MTLE/HS submitted to surgery were included. Histopathological analysis included: (1) quantitative: hippocampal subfields and total estimated hippocampal cell density (HCD), thickness of the dentate gyrus – normal, thinning or dispersion; (2) qualitative: type of HS and granule cells pathology in the dentate gyrus (normal, neuronal cell loss, dispersion and bilamination). Automated MRI-derived measurements from bilateral temporal structures (hippocampus, amygdala, parahippocampal gyrus, temporal pole, entorhinal cortex) were obtained for 58 subjects. Histopathological and imaging findings were compared with data from specimens obtained in autopsies of age-matched individuals and living controls, respectively, and the data were adjusted for the age at epilepsy onset and the frequency of focal impaired awareness seizures/month.
Forty-two (54.5%) patients presented right HS. The greater the duration of epilepsy, the smaller the total estimated HCD (p = 0.025; r = −0.259). Patients with a normal distribution of the granular cells had a shorter epilepsy duration than those with dispersion (p = 0.018) or thinning (p = 0.031). A reduced ipsilateral hippocampal volume (r = −0.551, p = 0.017) and a smaller hippocampal asymmetry index (r = −0.414, p = 0.002) were correlated to a longer epilepsy duration. The estimated HCD was correlated to the volume of the ipsilateral hippocampus (r = 0.420, p = 0.001).
Our study showed an increasing atrophy of the ipsilateral hippocampus in patients with a longer epilepsy duration. Our data suggest that this reduction in hippocampal volume is related to neuronal loss. Besides that, we also showed an increased probability of exhibiting an abnormal distribution of the granular cells in the dentate gyrus in patients with longer epilepsy duration.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Brain Mapping</subject><subject>Cell Count</subject><subject>Epilepsy, Temporal Lobe - complications</subject><subject>Epilepsy, Temporal Lobe - pathology</subject><subject>Female</subject><subject>FreeSurfer volumetry</subject><subject>Hippocampal sclerosis</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mesial temporal lobe epilepsy</subject><subject>Middle Aged</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Phosphopyruvate Hydratase - metabolism</subject><subject>Sclerosis - diagnostic imaging</subject><subject>Sclerosis - pathology</subject><subject>Young Adult</subject><issn>0920-1211</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU2PFCEQJUbjzq7-BcPRS89W0fTXUTeummziZe6EpqszTOgGgdbs1V8u46wfN5MKVODVe_AeYxxhj4Dt7WlPwVFIj5HSXgD2eygFwzO2w74TVdtL-ZztYBBQoUC8YtcpnQCgAylfsqsahOzbGnbsx-FI3C5Bm8z9zCnYX7x82qLO1q_crlzzRNFSOgNCOaU1J_7d5iNfKFnteKYl-Fga50f6l4N49nxbrdOZzvdHG4I3usg5noyj6JNNr9iLWbtEr5_2G3a4_3C4-1Q9fPn4-e7dQ2VEP-RqnkTT9ignI9FgS9AR4Gg0UIvdZGicmwlkI1rd67aWAyHU0jRlGbsR5vqGvb3Qhui_bpSyWmwy5JxeyW9JFZsEDoBDU6D9BWrKA1OkWYVoFx0fFYI6B6BO6m8A6hyAglIwlNE3TyrbuND0Z_C34wXw_gKg8tVvlqJKpjhqaLKRTFaTt_9X-Qmvl5-G</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Duarte, Jeana Torres Corso</creator><creator>Jardim, Anaclara Prada</creator><creator>Comper, Sandra Mara</creator><creator>De Marchi, Luciana Rodrigues</creator><creator>Gaça, Larissa Botelho</creator><creator>Garcia, Maria Teresa Fernandes Castilho</creator><creator>Sandim, Gabriel Barbosa</creator><creator>Assunção-Leme, Idaiane Batista</creator><creator>Carrete, Henrique</creator><creator>Centeno, Ricardo Silva</creator><creator>Lancellotti, Carmen Lúcia Penteado</creator><creator>Jackowski, Andrea P.</creator><creator>Cavalheiro, Esper Abrão</creator><creator>Guaranha, Mirian Salvadori Bittar</creator><creator>Yacubian, Elza Márcia Targas</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1016-7624</orcidid><orcidid>https://orcid.org/0000-0003-0654-9283</orcidid></search><sort><creationdate>201811</creationdate><title>The impact of epilepsy duration in a series of patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis</title><author>Duarte, Jeana Torres Corso ; Jardim, Anaclara Prada ; Comper, Sandra Mara ; De Marchi, Luciana Rodrigues ; Gaça, Larissa Botelho ; Garcia, Maria Teresa Fernandes Castilho ; Sandim, Gabriel Barbosa ; Assunção-Leme, Idaiane Batista ; Carrete, Henrique ; Centeno, Ricardo Silva ; Lancellotti, Carmen Lúcia Penteado ; Jackowski, Andrea P. ; Cavalheiro, Esper Abrão ; Guaranha, Mirian Salvadori Bittar ; Yacubian, Elza Márcia Targas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-fd256814dc41c16e07e01bca0e617dcebf5d04526a8a6349e1034c5034b7b0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Brain Mapping</topic><topic>Cell Count</topic><topic>Epilepsy, Temporal Lobe - complications</topic><topic>Epilepsy, Temporal Lobe - pathology</topic><topic>Female</topic><topic>FreeSurfer volumetry</topic><topic>Hippocampal sclerosis</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mesial temporal lobe epilepsy</topic><topic>Middle Aged</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Phosphopyruvate Hydratase - metabolism</topic><topic>Sclerosis - diagnostic imaging</topic><topic>Sclerosis - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duarte, Jeana Torres Corso</creatorcontrib><creatorcontrib>Jardim, Anaclara Prada</creatorcontrib><creatorcontrib>Comper, Sandra Mara</creatorcontrib><creatorcontrib>De Marchi, Luciana Rodrigues</creatorcontrib><creatorcontrib>Gaça, Larissa Botelho</creatorcontrib><creatorcontrib>Garcia, Maria Teresa Fernandes Castilho</creatorcontrib><creatorcontrib>Sandim, Gabriel Barbosa</creatorcontrib><creatorcontrib>Assunção-Leme, Idaiane Batista</creatorcontrib><creatorcontrib>Carrete, Henrique</creatorcontrib><creatorcontrib>Centeno, Ricardo Silva</creatorcontrib><creatorcontrib>Lancellotti, Carmen Lúcia Penteado</creatorcontrib><creatorcontrib>Jackowski, Andrea P.</creatorcontrib><creatorcontrib>Cavalheiro, Esper Abrão</creatorcontrib><creatorcontrib>Guaranha, Mirian Salvadori Bittar</creatorcontrib><creatorcontrib>Yacubian, Elza Márcia Targas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duarte, Jeana Torres Corso</au><au>Jardim, Anaclara Prada</au><au>Comper, Sandra Mara</au><au>De Marchi, Luciana Rodrigues</au><au>Gaça, Larissa Botelho</au><au>Garcia, Maria Teresa Fernandes Castilho</au><au>Sandim, Gabriel Barbosa</au><au>Assunção-Leme, Idaiane Batista</au><au>Carrete, Henrique</au><au>Centeno, Ricardo Silva</au><au>Lancellotti, Carmen Lúcia Penteado</au><au>Jackowski, Andrea P.</au><au>Cavalheiro, Esper Abrão</au><au>Guaranha, Mirian Salvadori Bittar</au><au>Yacubian, Elza Márcia Targas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of epilepsy duration in a series of patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>2018-11</date><risdate>2018</risdate><volume>147</volume><spage>51</spage><epage>57</epage><pages>51-57</pages><issn>0920-1211</issn><eissn>1872-6844</eissn><abstract>•Lower hippocampal cell density correlates to a longer epilepsy duration.•Thinning and dispersion of the granular cells are related to longer epilepsy duration.•Lower ipsilateral hippocampal volume is associated with a longer epilepsy duration.•Ipsilateral hippocampal volume correlates to the estimated hippocampal cell density.
To evaluate if the duration of epilepsy influences MRI volumes of the hippocampus, amygdala, parahippocampal gyrus, entorhinal cortex and temporal pole of both hemispheres and epileptogenic hippocampus neuronal cell density and dentate gyrus granular cells distribution in patients with refractory mesial temporal lobe epilepsy due to hippocampal sclerosis (MTLE/HS).
Seventy-seven patients with refractory MTLE/HS submitted to surgery were included. Histopathological analysis included: (1) quantitative: hippocampal subfields and total estimated hippocampal cell density (HCD), thickness of the dentate gyrus – normal, thinning or dispersion; (2) qualitative: type of HS and granule cells pathology in the dentate gyrus (normal, neuronal cell loss, dispersion and bilamination). Automated MRI-derived measurements from bilateral temporal structures (hippocampus, amygdala, parahippocampal gyrus, temporal pole, entorhinal cortex) were obtained for 58 subjects. Histopathological and imaging findings were compared with data from specimens obtained in autopsies of age-matched individuals and living controls, respectively, and the data were adjusted for the age at epilepsy onset and the frequency of focal impaired awareness seizures/month.
Forty-two (54.5%) patients presented right HS. The greater the duration of epilepsy, the smaller the total estimated HCD (p = 0.025; r = −0.259). Patients with a normal distribution of the granular cells had a shorter epilepsy duration than those with dispersion (p = 0.018) or thinning (p = 0.031). A reduced ipsilateral hippocampal volume (r = −0.551, p = 0.017) and a smaller hippocampal asymmetry index (r = −0.414, p = 0.002) were correlated to a longer epilepsy duration. The estimated HCD was correlated to the volume of the ipsilateral hippocampus (r = 0.420, p = 0.001).
Our study showed an increasing atrophy of the ipsilateral hippocampus in patients with a longer epilepsy duration. Our data suggest that this reduction in hippocampal volume is related to neuronal loss. Besides that, we also showed an increased probability of exhibiting an abnormal distribution of the granular cells in the dentate gyrus in patients with longer epilepsy duration.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30248630</pmid><doi>10.1016/j.eplepsyres.2018.08.009</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1016-7624</orcidid><orcidid>https://orcid.org/0000-0003-0654-9283</orcidid></addata></record> |
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| ispartof | Epilepsy research, 2018-11, Vol.147, p.51-57 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Brain - diagnostic imaging Brain - pathology Brain Mapping Cell Count Epilepsy, Temporal Lobe - complications Epilepsy, Temporal Lobe - pathology Female FreeSurfer volumetry Hippocampal sclerosis Hippocampus - diagnostic imaging Hippocampus - pathology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Mesial temporal lobe epilepsy Middle Aged Neurons - metabolism Neurons - pathology Phosphopyruvate Hydratase - metabolism Sclerosis - diagnostic imaging Sclerosis - pathology Young Adult |
| title | The impact of epilepsy duration in a series of patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis |
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