1,2,3-Triazole fused with pyridine/pyrimidine as new template for antimicrobial agents: Regioselective synthesis and identification of potent N-heteroarenes

The 1,2,3-triazole fused pyridine/pyrimidine derivatives were synthesized and evaluated as new and potential antimicrobial agents. [Display omitted] •Explored 1,2,3-triazolo pyridine/pyrimidine as new template for antimicrobial agents.•Demonstrated the application of Buchwald’s strategy to N-heteroa...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2018-11, Vol.28 (20), p.3302-3306
Hauptverfasser:	Marepu, Nagaraju, Yeturu, Sunandamma, Pal, Manojit
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3-Triazole Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial Antifungal Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Bacillus subtilis - drug effects Buchwald’s strategy Cyclization Drug Design Escherichia coli - drug effects Fusarium - drug effects Maneb - pharmacology Microbial Sensitivity Tests Molecular Structure Oxidation-Reduction Pyridine Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Streptomycin - pharmacology Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacology Zineb - pharmacology
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