Residual detection of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate in aquatic products by simple liquid–liquid extraction method coupled with liquid chromatography–tandem mass spectrometry
In the present study, we aimed to develop a reliable screening method based on liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) for the detection and quantification of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate residues. The target analytes were extracted...
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| Veröffentlicht in: | Biomedical chromatography 2019-01, Vol.33 (1), p.e4396-n/a |
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| creator | Zheng, Weijia Yoo, Kyung‐Hee Choi, Jeong‐Min Park, Da‐Hee Kim, Seong‐Kwan Kang, Young‐Sun Abd El‐Aty, A. M. Hacımüftüoğlu, Ahmet Wang, Jing Shim, Jae‐Han Shin, Ho‐Chul |
| description | In the present study, we aimed to develop a reliable screening method based on liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) for the detection and quantification of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate residues. The target analytes were extracted from samples of eel, flatfish and shrimp using acetonitrile with 1% acetic acid, followed by liquid–liquid purification with n‐hexane. Chromatographic separation was achieved on a reversed‐phase analytical column using 0.1% formic acid containing 10 mm ammonium formate in distilled water (A) and methanol (B) as mobile phases. All the matrix‐matched calibration curves were linear (R2 ≥ 0.99) over the concentration range of the tested analytes. Recovery at three spiking levels (0.005, 0.01 and 0.02 mg/kg) ranged from 68 to 117% with intra‐ and inter‐day precisions |
| doi_str_mv | 10.1002/bmc.4396 |
| format | Article |
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M. ; Hacımüftüoğlu, Ahmet ; Wang, Jing ; Shim, Jae‐Han ; Shin, Ho‐Chul</creator><creatorcontrib>Zheng, Weijia ; Yoo, Kyung‐Hee ; Choi, Jeong‐Min ; Park, Da‐Hee ; Kim, Seong‐Kwan ; Kang, Young‐Sun ; Abd El‐Aty, A. M. ; Hacımüftüoğlu, Ahmet ; Wang, Jing ; Shim, Jae‐Han ; Shin, Ho‐Chul</creatorcontrib><description>In the present study, we aimed to develop a reliable screening method based on liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) for the detection and quantification of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate residues. The target analytes were extracted from samples of eel, flatfish and shrimp using acetonitrile with 1% acetic acid, followed by liquid–liquid purification with n‐hexane. Chromatographic separation was achieved on a reversed‐phase analytical column using 0.1% formic acid containing 10 mm ammonium formate in distilled water (A) and methanol (B) as mobile phases. All the matrix‐matched calibration curves were linear (R2 ≥ 0.99) over the concentration range of the tested analytes. Recovery at three spiking levels (0.005, 0.01 and 0.02 mg/kg) ranged from 68 to 117% with intra‐ and inter‐day precisions <10%. Five market samples for each matrix (eel, flatfish and shrimp) were collected and tested for method application. In summary, the proposed method is feasible to screen and quantify the analytes with high selectivity in aquatic food products meant for human consumption.</description><identifier>ISSN: 0269-3879</identifier><identifier>EISSN: 1099-0801</identifier><identifier>DOI: 10.1002/bmc.4396</identifier><identifier>PMID: 30246262</identifier><language>eng</language><publisher>England</publisher><subject>17 alpha-Hydroxyprogesterone Caproate - analysis ; 17 alpha-Hydroxyprogesterone Caproate - isolation & purification ; 17α‐hydroxyprogesterone carproate ; Animals ; aquatic product ; Chromatography, Liquid - methods ; Drug Residues - analysis ; Eels ; Flatfishes ; LC–MS/MS ; Limit of Detection ; Linear Models ; Liquid-Liquid Extraction - methods ; methyltestosterone ; Methyltestosterone - analysis ; Methyltestosterone - isolation & purification ; naproxen ; Naproxen - analysis ; Naproxen - isolation & purification ; Penaeidae ; Reproducibility of Results ; residue ; Seafood - analysis ; Tandem Mass Spectrometry - methods</subject><ispartof>Biomedical chromatography, 2019-01, Vol.33 (1), p.e4396-n/a</ispartof><rights>2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3556-281038978320e4a6b188244fe45c563a7e5946a04e680a0a5422cb12190a52903</citedby><cites>FETCH-LOGICAL-c3556-281038978320e4a6b188244fe45c563a7e5946a04e680a0a5422cb12190a52903</cites><orcidid>0000-0001-5500-3901 ; 0000-0002-5361-2903 ; 0000-0001-6596-7907</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbmc.4396$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbmc.4396$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30246262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Weijia</creatorcontrib><creatorcontrib>Yoo, Kyung‐Hee</creatorcontrib><creatorcontrib>Choi, Jeong‐Min</creatorcontrib><creatorcontrib>Park, Da‐Hee</creatorcontrib><creatorcontrib>Kim, Seong‐Kwan</creatorcontrib><creatorcontrib>Kang, Young‐Sun</creatorcontrib><creatorcontrib>Abd El‐Aty, A. M.</creatorcontrib><creatorcontrib>Hacımüftüoğlu, Ahmet</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Shim, Jae‐Han</creatorcontrib><creatorcontrib>Shin, Ho‐Chul</creatorcontrib><title>Residual detection of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate in aquatic products by simple liquid–liquid extraction method coupled with liquid chromatography–tandem mass spectrometry</title><title>Biomedical chromatography</title><addtitle>Biomed Chromatogr</addtitle><description>In the present study, we aimed to develop a reliable screening method based on liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) for the detection and quantification of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate residues. The target analytes were extracted from samples of eel, flatfish and shrimp using acetonitrile with 1% acetic acid, followed by liquid–liquid purification with n‐hexane. Chromatographic separation was achieved on a reversed‐phase analytical column using 0.1% formic acid containing 10 mm ammonium formate in distilled water (A) and methanol (B) as mobile phases. All the matrix‐matched calibration curves were linear (R2 ≥ 0.99) over the concentration range of the tested analytes. Recovery at three spiking levels (0.005, 0.01 and 0.02 mg/kg) ranged from 68 to 117% with intra‐ and inter‐day precisions <10%. Five market samples for each matrix (eel, flatfish and shrimp) were collected and tested for method application. In summary, the proposed method is feasible to screen and quantify the analytes with high selectivity in aquatic food products meant for human consumption.</description><subject>17 alpha-Hydroxyprogesterone Caproate - analysis</subject><subject>17 alpha-Hydroxyprogesterone Caproate - isolation & purification</subject><subject>17α‐hydroxyprogesterone carproate</subject><subject>Animals</subject><subject>aquatic product</subject><subject>Chromatography, Liquid - methods</subject><subject>Drug Residues - analysis</subject><subject>Eels</subject><subject>Flatfishes</subject><subject>LC–MS/MS</subject><subject>Limit of Detection</subject><subject>Linear Models</subject><subject>Liquid-Liquid Extraction - methods</subject><subject>methyltestosterone</subject><subject>Methyltestosterone - analysis</subject><subject>Methyltestosterone - isolation & purification</subject><subject>naproxen</subject><subject>Naproxen - analysis</subject><subject>Naproxen - isolation & purification</subject><subject>Penaeidae</subject><subject>Reproducibility of Results</subject><subject>residue</subject><subject>Seafood - analysis</subject><subject>Tandem Mass Spectrometry - methods</subject><issn>0269-3879</issn><issn>1099-0801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAQxy1ERbcFiSdAPnIgrb_ixEdYlQ-pCAnBOXKc2cYojrO2oza3PgIST8KL9My5T4KX3cKJ04xmfvP3jP8IPafkjBLCzltnzgRX8hFaUaJUQWpCH6MVYVIVvK7UMTqJ8RshRElWPUHHnDAhmWQr9OszRNvNesAdJDDJ-hH7DR71FPwNjK-wg9QvQ4KYfEwQ_AhYjx2m1d3P-9vv_dJlbsnwFTy0zW5WJ8B2xHo762QNzpVuNinidsHRumkAPNjtbLv72x_7BMNNCnq_wO5N32Hj5wx2-Nqm_oBj0wfvdPJXQU_9kqdT3gYcdjpGHKd8Qe5DCstTdLTRQ4Rnh3iKvr69-LJ-X1x-evdh_fqyMLwsZcFqSnitqpozAkLLltY1E2IDojSl5LqCUgmpiQBZE010KRgzLWVU5Zwpwk_Ry71uPnE7509onI0GhkGP4OfYMEppJSSX8h9qgo8xwKaZgnU6LA0lzc7HJvvY7HzM6IuD6tw66P6CD8ZloNgD13aA5b9CzZuP6z-CvwEprbDV</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Zheng, Weijia</creator><creator>Yoo, Kyung‐Hee</creator><creator>Choi, Jeong‐Min</creator><creator>Park, Da‐Hee</creator><creator>Kim, Seong‐Kwan</creator><creator>Kang, Young‐Sun</creator><creator>Abd El‐Aty, A. M.</creator><creator>Hacımüftüoğlu, Ahmet</creator><creator>Wang, Jing</creator><creator>Shim, Jae‐Han</creator><creator>Shin, Ho‐Chul</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5500-3901</orcidid><orcidid>https://orcid.org/0000-0002-5361-2903</orcidid><orcidid>https://orcid.org/0000-0001-6596-7907</orcidid></search><sort><creationdate>201901</creationdate><title>Residual detection of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate in aquatic products by simple liquid–liquid extraction method coupled with liquid chromatography–tandem mass spectrometry</title><author>Zheng, Weijia ; Yoo, Kyung‐Hee ; Choi, Jeong‐Min ; Park, Da‐Hee ; Kim, Seong‐Kwan ; Kang, Young‐Sun ; Abd El‐Aty, A. 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M.</creatorcontrib><creatorcontrib>Hacımüftüoğlu, Ahmet</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Shim, Jae‐Han</creatorcontrib><creatorcontrib>Shin, Ho‐Chul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedical chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Weijia</au><au>Yoo, Kyung‐Hee</au><au>Choi, Jeong‐Min</au><au>Park, Da‐Hee</au><au>Kim, Seong‐Kwan</au><au>Kang, Young‐Sun</au><au>Abd El‐Aty, A. M.</au><au>Hacımüftüoğlu, Ahmet</au><au>Wang, Jing</au><au>Shim, Jae‐Han</au><au>Shin, Ho‐Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Residual detection of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate in aquatic products by simple liquid–liquid extraction method coupled with liquid chromatography–tandem mass spectrometry</atitle><jtitle>Biomedical chromatography</jtitle><addtitle>Biomed Chromatogr</addtitle><date>2019-01</date><risdate>2019</risdate><volume>33</volume><issue>1</issue><spage>e4396</spage><epage>n/a</epage><pages>e4396-n/a</pages><issn>0269-3879</issn><eissn>1099-0801</eissn><abstract>In the present study, we aimed to develop a reliable screening method based on liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) for the detection and quantification of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate residues. The target analytes were extracted from samples of eel, flatfish and shrimp using acetonitrile with 1% acetic acid, followed by liquid–liquid purification with n‐hexane. Chromatographic separation was achieved on a reversed‐phase analytical column using 0.1% formic acid containing 10 mm ammonium formate in distilled water (A) and methanol (B) as mobile phases. All the matrix‐matched calibration curves were linear (R2 ≥ 0.99) over the concentration range of the tested analytes. Recovery at three spiking levels (0.005, 0.01 and 0.02 mg/kg) ranged from 68 to 117% with intra‐ and inter‐day precisions <10%. Five market samples for each matrix (eel, flatfish and shrimp) were collected and tested for method application. In summary, the proposed method is feasible to screen and quantify the analytes with high selectivity in aquatic food products meant for human consumption.</abstract><cop>England</cop><pmid>30246262</pmid><doi>10.1002/bmc.4396</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5500-3901</orcidid><orcidid>https://orcid.org/0000-0002-5361-2903</orcidid><orcidid>https://orcid.org/0000-0001-6596-7907</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 17 alpha-Hydroxyprogesterone Caproate - analysis 17 alpha-Hydroxyprogesterone Caproate - isolation & purification 17α‐hydroxyprogesterone carproate Animals aquatic product Chromatography, Liquid - methods Drug Residues - analysis Eels Flatfishes LC–MS/MS Limit of Detection Linear Models Liquid-Liquid Extraction - methods methyltestosterone Methyltestosterone - analysis Methyltestosterone - isolation & purification naproxen Naproxen - analysis Naproxen - isolation & purification Penaeidae Reproducibility of Results residue Seafood - analysis Tandem Mass Spectrometry - methods |
| title | Residual detection of naproxen, methyltestosterone and 17α‐hydroxyprogesterone caproate in aquatic products by simple liquid–liquid extraction method coupled with liquid chromatography–tandem mass spectrometry |
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