Recent advances in endotoxin tolerance

Endotoxin tolerance is defined as a reduced capacity of a cell to respond endotoxin (lipopolysaccharide, LPS) challenge after an initial encounter with endotoxin in advance. The body becomes tolerant to subsequent challenge with a lethal dose of endotoxin and cytokines release and cell/tissue damage...

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Veröffentlicht in:	Journal of cellular biochemistry 2019-01, Vol.120 (1), p.56-70
Hauptverfasser:	Liu, Dan, Cao, Shousong, Zhou, Yejiang, Xiong, Yuxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - immunology Cancer Cell surface Chromatin chromatin modification and gene reprogramming CXCL10 protein Cystic fibrosis Cytokines Diseases Endotoxemia endotoxin (lipopolysaccharide) Endotoxin shock endotoxin tolerance Endotoxins Growth factors host defense Humans Immune system Immunological tolerance Inflammation Inflammation - immunology Inflammation - pathology Interleukins Ischemia Lethal dose Lipopolysaccharides Lipopolysaccharides - immunology Lipopolysaccharides - toxicity Liver microRNAs miRNA Molecular modelling negative regulate factors Proteins Regulatory mechanisms (biology) Reperfusion Sepsis Shock, Septic - immunology Shock, Septic - pathology Signal processing Signal transduction Signal Transduction - drug effects Signal Transduction - immunology Signaling TLR4 protein Toll-like receptors Transforming growth factor Transforming growth factor-b Tumor necrosis factor-TNF Tumor necrosis factor-α
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