PCSK9: A novel inflammation modulator in atherosclerosis?

Proprotein convertase subtilisin/kexin 9 (PCSK9) is the ninth member of the secretory serine protease family. It binds to low‐density lipoprotein receptor (LDLR) for endocytosis and lysosome degradation in the liver, resulting in an increasing in circulating LDL‐cholesterol (LDL‐c) level. Since a PC...

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Veröffentlicht in:	Journal of cellular physiology 2019-03, Vol.234 (3), p.2345-2355
Hauptverfasser:	Tang, Zhi‐Han, Li, Tao‐Hua, Peng, Juan, Zheng, Jie, Li, Ting‐Ting, Liu, Lu‐Shan, Jiang, Zhi‐Sheng, Zheng, Xi‐Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis Atherosclerosis Atherosclerosis - blood Atherosclerosis - genetics Atherosclerosis - pathology Blood Vessels - metabolism Blood Vessels - pathology Cardiovascular diseases Cholesterol Cholesterol, LDL - blood Endocytosis Endocytosis - genetics Humans Inflammation Inflammation - blood Inflammation - genetics Inflammation - pathology Kexin Liver Low density lipoprotein Low density lipoprotein receptors Lysosomes - genetics Lysosomes - metabolism PCSK9 Proprotein Convertase 9 - genetics Proprotein convertases Receptor density Receptors, LDL - genetics Serine Serine proteinase Subtilisin vascular cells
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