Activity of oxygen-versus sulfur-containing analogs of the Flex-Het anticancer agent SHetA2

Five series of chromans with urea and thiourea linkers connecting a chroman unit (ring A) and a 4-substituted benzene unit (ring B) have been prepared and evaluated relative to SHetA2 (NSC 721689) for activity against the human A2780 ovarian cancer cell line. The lead compound SHetA2 had a sulfur in...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-10, Vol.158, p.720-732
Hauptverfasser:	Watts, Field M., Pouland, Tim, Bunce, Richard A., Berlin, K. Darrell, Benbrook, Doris M., Mashayekhi, Maryam, Bhandari, Dipendra, Zhou, Donghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Chroman-based anticancer agents Chromans - chemical synthesis Chromans - chemistry Chromans - pharmacology Female HSP70 Heat-Shock Proteins - metabolism Humans In silico docking study Molecular Docking Simulation Mortalin Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Oxygen - chemistry Oxygen - pharmacology Polarity and electronic optimization SHetA2 Sulfur - chemistry Sulfur - pharmacology Thiones - chemical synthesis Thiones - chemistry Thiones - pharmacology Thiourea - analogs & derivatives Thiourea - chemical synthesis Thiourea - pharmacology Urea - analogs & derivatives Urea - chemical synthesis Urea - pharmacology
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