The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor

A significant proportion of familial and early-onset breast and ovarian cancers occur in individuals without coding mutations of BRCA1 and BRCA2. We identified genetic variation at 3'-untranslated region (UTR) of BRCA1 in familial and early-onset breast and ovarian cancer patients both with and...

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Veröffentlicht in:	Genetic testing and molecular biomarkers 2009-06, Vol.13 (3), p.307-317
Hauptverfasser:	Pongsavee, Malinee, Yamkamon, Vichanan, Dakeng, Sumana, O-charoenrat, Pornchai, Smith, Duncan R, Saunders, Grady F, Patmasiriwat, Pimpicha
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Adult Aged Alleles BRCA mutations BRCA1 Protein - genetics Breast cancer Breast Neoplasms - genetics Cancer Case-Control Studies Female Gene Frequency Genes, BRCA1 Genes, Reporter Genetic aspects Genetic Variation Genotype Health aspects Heteroduplex Analysis Heterozygote Homozygote Humans Identification and classification Luciferases - metabolism Middle Aged Mutagenesis, Site-Directed Ovarian cancer Ovarian Neoplasms - genetics Polymorphism, Single Nucleotide Risk Factors Sequence Analysis, DNA Thailand Thais Transfection
Online-Zugang:	Volltext
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