A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data

Objective Olanzapine (OLZ) is unique among currently available antipsychotic medications in its antagonism of a range of receptor systems including dopamine, norepinephrine, serotonin, acetylcholine, and histamine. Olanzapine's mechanistic complexity provides a broad efficacy profile in patient...

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Veröffentlicht in:	International journal of geriatric psychiatry 2001-12, Vol.16 (S1), p.S33-S61
Hauptverfasser:	Kennedy, John S., Bymaster, Frank P., Schuh, Leslie, Calligaro, David O., Nomikos, George, Felder, Christian C., Bernauer, Mark, Kinon, Bruce J., Baker, Robert W., Hay, Donald, Roth, H. John, Dossenbach, Martin, Kaiser, Christopher, Beasley, Charles M., Holcombe, John H., Effron, Mark B., Breier, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse Drug Reaction Reporting Systems Aged Alzheimer Disease - drug therapy Alzheimer's dementia Animals Benzodiazepines bipolar disorder Brain - drug effects dementia diabetes Drug Evaluation, Preclinical geriatric Humans Neurologic Examination - drug effects olanzapine Pirenzepine - adverse effects Pirenzepine - analogs & derivatives Pirenzepine - therapeutic use receptors Receptors, Neurotransmitter - drug effects safety schizophrenia
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