Reduction in Peripheral Lymphocytes and Thymus Atrophy Induced by Organotin Compounds In Vivo

To clarify the involvement of apoptosis in the immunotoxicity of organotin compounds, we examined the induction of apoptosis in the peripheral lymphocytes and thymus of mice treated with triphenyltin (TPT), tributyltin (TBT) or dexamethasone (Dex). Application of TPT or TBT and Dex resulted in a tra...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2009, Vol.71(8), pp.1041-1048
Hauptverfasser:	UENO, Shunji, KASHIMOTO, Takashige, SUSA, Nobuyuki, ASAI, Tomohito, KAWAGUCHI, Souta, TAKEDA-HOMMA, Shino, TERADA, Yasuko, SUGIYAMA, Masayasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Atrophy Dexamethasone - toxicity Flow Cytometry Kinetics Lymphocyte Count Lymphocytes - cytology Lymphocytes - drug effects Male Mice Mice, Inbred ICR organotin compounds Organotin Compounds - blood Organotin Compounds - toxicity peripheral lymphocytes thymus atrophy Thymus Gland - drug effects Thymus Gland - pathology Trialkyltin Compounds - toxicity
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