Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome
There is increasing evidence for Müllerian-inhibiting substance (MIS)/anti-Müllerian hormone (AMH) physiologic activity in the human uterus, so it is relevant to study how MIS/AMH levels impact pregnancy. To investigate the association of MIS/AMH levels with the risk of adverse obstetric outcomes. R...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2018-11, Vol.103 (11), p.4187-4196 |
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| creator | Hsu, Jennifer Y James, Kaitlyn E Bormann, Charles L Donahoe, Patricia K Pépin, David Sabatini, Mary E |
| description | There is increasing evidence for Müllerian-inhibiting substance (MIS)/anti-Müllerian hormone (AMH) physiologic activity in the human uterus, so it is relevant to study how MIS/AMH levels impact pregnancy.
To investigate the association of MIS/AMH levels with the risk of adverse obstetric outcomes.
Retrospective cohort study.
Academic fertility center.
Women who became pregnant through in vitro fertilization between January 2012 and October 2016. Exclusion criteria were: oocyte donation, gestational carrier, multiple gestations, miscarriage before 20 weeks, or medically indicated preterm deliveries.
None.
There were two primary outcomes, preterm birth and cesarean delivery for arrest of labor. Because MIS/AMH level is highly skewed by certain infertility diagnoses, the preterm birth analysis was stratified by polycystic ovary syndrome (PCOS) diagnosis, and the cesarean delivery for arrest of labor analysis was stratified by diminished ovarian reserve diagnosis. χ2, Mann-Whitney, and t tests were used as appropriate. A P value of |
| doi_str_mv | 10.1210/jc.2018-01320 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2111152974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2364253125</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4020-78de8079bb6929f31d3ee7287a0fa0f18628ef47b419ec3260dbedcd85c59f1c3</originalsourceid><addsrcrecordid>eNpdkd9rFDEQx4NY7Hn66KsEfPElbX7sXjaPtagtVFpoBd9CNjvr5cwmNcla7n_zzX_MnFdb6DDDMPDhy8x8EXrD6BHjjB5v7BGnrCOUCU6foQVTTUskU_I5WlDKGVGSfztEL3PeUMqaphUv0KGgXKiOtgtUvvz57T0kZwI5D2vXu-LCd3w997mYYOH4JBRHHiF8FtMUA2CTscFXCQZnS0w4jruhQJrwB5fKGruAr6Lf2m0uzuLLXyZt8fU2DClO8AodjMZneH3fl-jrp483p2fk4vLz-enJBbEN5ZTIboCOStX3K8XVKNggACTvpKFjTdateAdjI_uGKbCCr-jQw2CHrrWtGpkVS_R-r3ub4s8ZctGTyxa8NwHinDVnNVquZFPRd0_QTZxTqNtpLlYNbwWrtURkT9kUc04w6tvkpnqaZlTv7NAbq3d26H92VP7tvercTzA80P__XwG2B-6ir8_LP_x8B0mvwfiyfiq691j8BcRzlwg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2364253125</pqid></control><display><type>article</type><title>Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome</title><source>ProQuest One Community College</source><source>MEDLINE</source><source>Oxford Journals - Connect here FIRST to enable access</source><source>Journals@Ovid Complete</source><source>ProQuest Central (Alumni)</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><source>ProQuest Central</source><creator>Hsu, Jennifer Y ; James, Kaitlyn E ; Bormann, Charles L ; Donahoe, Patricia K ; Pépin, David ; Sabatini, Mary E</creator><creatorcontrib>Hsu, Jennifer Y ; James, Kaitlyn E ; Bormann, Charles L ; Donahoe, Patricia K ; Pépin, David ; Sabatini, Mary E</creatorcontrib><description>There is increasing evidence for Müllerian-inhibiting substance (MIS)/anti-Müllerian hormone (AMH) physiologic activity in the human uterus, so it is relevant to study how MIS/AMH levels impact pregnancy.
To investigate the association of MIS/AMH levels with the risk of adverse obstetric outcomes.
Retrospective cohort study.
Academic fertility center.
Women who became pregnant through in vitro fertilization between January 2012 and October 2016. Exclusion criteria were: oocyte donation, gestational carrier, multiple gestations, miscarriage before 20 weeks, or medically indicated preterm deliveries.
None.
There were two primary outcomes, preterm birth and cesarean delivery for arrest of labor. Because MIS/AMH level is highly skewed by certain infertility diagnoses, the preterm birth analysis was stratified by polycystic ovary syndrome (PCOS) diagnosis, and the cesarean delivery for arrest of labor analysis was stratified by diminished ovarian reserve diagnosis. χ2, Mann-Whitney, and t tests were used as appropriate. A P value of <0.05 was considered statistically significant.
Among women with PCOS, those who delivered prematurely had substantially higher MIS/AMH levels (18 vs 6.4 ng/mL, P = 0.003) than did those who delivered at term. At the highest MIS/AMH values, preterm deliveries predominated; above the 90th percentile in women with PCOS, all deliveries were premature. No effect of MIS/AMH level was observed in women without PCOS. We found no association between MIS/AMH values and cesarean delivery for labor arrest.
In women with PCOS, substantially elevated MIS/AMH levels are significantly associated with preterm birth, suggesting closer follow-up and further studies to elucidate the underlying mechanisms.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2018-01320</identifier><identifier>PMID: 30239805</identifier><language>eng</language><publisher>United States: Copyright Oxford University Press</publisher><subject>Adult ; Anti-Mullerian Hormone - blood ; Birth ; Cesarean section ; Cesarean Section - statistics & numerical data ; Diagnosis ; Dystocia - blood ; Dystocia - diagnosis ; Dystocia - etiology ; Dystocia - surgery ; Female ; Humans ; In vitro fertilization ; Infant, Newborn ; Infertility ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Pregnancy ; Premature birth ; Premature Birth - diagnosis ; Premature Birth - etiology ; Prognosis ; Retrospective Studies ; Statistical analysis ; Uterine Inertia ; Uterus</subject><ispartof>The journal of clinical endocrinology and metabolism, 2018-11, Vol.103 (11), p.4187-4196</ispartof><rights>Copyright © Oxford University Press 2015</rights><rights>Copyright © 2018 Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4020-78de8079bb6929f31d3ee7287a0fa0f18628ef47b419ec3260dbedcd85c59f1c3</citedby><cites>FETCH-LOGICAL-c4020-78de8079bb6929f31d3ee7287a0fa0f18628ef47b419ec3260dbedcd85c59f1c3</cites><orcidid>0000-0001-6928-2585</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2364253125?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,27924,27925,33530,33531,33744,33745,43659,43805,64385,64387,64389,72469,73123,73128,73129,73131</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30239805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, Jennifer Y</creatorcontrib><creatorcontrib>James, Kaitlyn E</creatorcontrib><creatorcontrib>Bormann, Charles L</creatorcontrib><creatorcontrib>Donahoe, Patricia K</creatorcontrib><creatorcontrib>Pépin, David</creatorcontrib><creatorcontrib>Sabatini, Mary E</creatorcontrib><title>Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>There is increasing evidence for Müllerian-inhibiting substance (MIS)/anti-Müllerian hormone (AMH) physiologic activity in the human uterus, so it is relevant to study how MIS/AMH levels impact pregnancy.
To investigate the association of MIS/AMH levels with the risk of adverse obstetric outcomes.
Retrospective cohort study.
Academic fertility center.
Women who became pregnant through in vitro fertilization between January 2012 and October 2016. Exclusion criteria were: oocyte donation, gestational carrier, multiple gestations, miscarriage before 20 weeks, or medically indicated preterm deliveries.
None.
There were two primary outcomes, preterm birth and cesarean delivery for arrest of labor. Because MIS/AMH level is highly skewed by certain infertility diagnoses, the preterm birth analysis was stratified by polycystic ovary syndrome (PCOS) diagnosis, and the cesarean delivery for arrest of labor analysis was stratified by diminished ovarian reserve diagnosis. χ2, Mann-Whitney, and t tests were used as appropriate. A P value of <0.05 was considered statistically significant.
Among women with PCOS, those who delivered prematurely had substantially higher MIS/AMH levels (18 vs 6.4 ng/mL, P = 0.003) than did those who delivered at term. At the highest MIS/AMH values, preterm deliveries predominated; above the 90th percentile in women with PCOS, all deliveries were premature. No effect of MIS/AMH level was observed in women without PCOS. We found no association between MIS/AMH values and cesarean delivery for labor arrest.
In women with PCOS, substantially elevated MIS/AMH levels are significantly associated with preterm birth, suggesting closer follow-up and further studies to elucidate the underlying mechanisms.</description><subject>Adult</subject><subject>Anti-Mullerian Hormone - blood</subject><subject>Birth</subject><subject>Cesarean section</subject><subject>Cesarean Section - statistics & numerical data</subject><subject>Diagnosis</subject><subject>Dystocia - blood</subject><subject>Dystocia - diagnosis</subject><subject>Dystocia - etiology</subject><subject>Dystocia - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infant, Newborn</subject><subject>Infertility</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Premature Birth - diagnosis</subject><subject>Premature Birth - etiology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Uterine Inertia</subject><subject>Uterus</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkd9rFDEQx4NY7Hn66KsEfPElbX7sXjaPtagtVFpoBd9CNjvr5cwmNcla7n_zzX_MnFdb6DDDMPDhy8x8EXrD6BHjjB5v7BGnrCOUCU6foQVTTUskU_I5WlDKGVGSfztEL3PeUMqaphUv0KGgXKiOtgtUvvz57T0kZwI5D2vXu-LCd3w997mYYOH4JBRHHiF8FtMUA2CTscFXCQZnS0w4jruhQJrwB5fKGruAr6Lf2m0uzuLLXyZt8fU2DClO8AodjMZneH3fl-jrp483p2fk4vLz-enJBbEN5ZTIboCOStX3K8XVKNggACTvpKFjTdateAdjI_uGKbCCr-jQw2CHrrWtGpkVS_R-r3ub4s8ZctGTyxa8NwHinDVnNVquZFPRd0_QTZxTqNtpLlYNbwWrtURkT9kUc04w6tvkpnqaZlTv7NAbq3d26H92VP7tvercTzA80P__XwG2B-6ir8_LP_x8B0mvwfiyfiq691j8BcRzlwg</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Hsu, Jennifer Y</creator><creator>James, Kaitlyn E</creator><creator>Bormann, Charles L</creator><creator>Donahoe, Patricia K</creator><creator>Pépin, David</creator><creator>Sabatini, Mary E</creator><general>Copyright Oxford University Press</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6928-2585</orcidid></search><sort><creationdate>201811</creationdate><title>Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome</title><author>Hsu, Jennifer Y ; James, Kaitlyn E ; Bormann, Charles L ; Donahoe, Patricia K ; Pépin, David ; Sabatini, Mary E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4020-78de8079bb6929f31d3ee7287a0fa0f18628ef47b419ec3260dbedcd85c59f1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Anti-Mullerian Hormone - blood</topic><topic>Birth</topic><topic>Cesarean section</topic><topic>Cesarean Section - statistics & numerical data</topic><topic>Diagnosis</topic><topic>Dystocia - blood</topic><topic>Dystocia - diagnosis</topic><topic>Dystocia - etiology</topic><topic>Dystocia - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infant, Newborn</topic><topic>Infertility</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Pregnancy</topic><topic>Premature birth</topic><topic>Premature Birth - diagnosis</topic><topic>Premature Birth - etiology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Uterine Inertia</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Jennifer Y</creatorcontrib><creatorcontrib>James, Kaitlyn E</creatorcontrib><creatorcontrib>Bormann, Charles L</creatorcontrib><creatorcontrib>Donahoe, Patricia K</creatorcontrib><creatorcontrib>Pépin, David</creatorcontrib><creatorcontrib>Sabatini, Mary E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Jennifer Y</au><au>James, Kaitlyn E</au><au>Bormann, Charles L</au><au>Donahoe, Patricia K</au><au>Pépin, David</au><au>Sabatini, Mary E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2018-11</date><risdate>2018</risdate><volume>103</volume><issue>11</issue><spage>4187</spage><epage>4196</epage><pages>4187-4196</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>There is increasing evidence for Müllerian-inhibiting substance (MIS)/anti-Müllerian hormone (AMH) physiologic activity in the human uterus, so it is relevant to study how MIS/AMH levels impact pregnancy.
To investigate the association of MIS/AMH levels with the risk of adverse obstetric outcomes.
Retrospective cohort study.
Academic fertility center.
Women who became pregnant through in vitro fertilization between January 2012 and October 2016. Exclusion criteria were: oocyte donation, gestational carrier, multiple gestations, miscarriage before 20 weeks, or medically indicated preterm deliveries.
None.
There were two primary outcomes, preterm birth and cesarean delivery for arrest of labor. Because MIS/AMH level is highly skewed by certain infertility diagnoses, the preterm birth analysis was stratified by polycystic ovary syndrome (PCOS) diagnosis, and the cesarean delivery for arrest of labor analysis was stratified by diminished ovarian reserve diagnosis. χ2, Mann-Whitney, and t tests were used as appropriate. A P value of <0.05 was considered statistically significant.
Among women with PCOS, those who delivered prematurely had substantially higher MIS/AMH levels (18 vs 6.4 ng/mL, P = 0.003) than did those who delivered at term. At the highest MIS/AMH values, preterm deliveries predominated; above the 90th percentile in women with PCOS, all deliveries were premature. No effect of MIS/AMH level was observed in women without PCOS. We found no association between MIS/AMH values and cesarean delivery for labor arrest.
In women with PCOS, substantially elevated MIS/AMH levels are significantly associated with preterm birth, suggesting closer follow-up and further studies to elucidate the underlying mechanisms.</abstract><cop>United States</cop><pub>Copyright Oxford University Press</pub><pmid>30239805</pmid><doi>10.1210/jc.2018-01320</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6928-2585</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anti-Mullerian Hormone - blood Birth Cesarean section Cesarean Section - statistics & numerical data Diagnosis Dystocia - blood Dystocia - diagnosis Dystocia - etiology Dystocia - surgery Female Humans In vitro fertilization Infant, Newborn Infertility Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - complications Pregnancy Premature birth Premature Birth - diagnosis Premature Birth - etiology Prognosis Retrospective Studies Statistical analysis Uterine Inertia Uterus |
| title | Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome |
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