Visible-Light-Mediated Decarboxylative Benzylation of Imines with Arylacetic Acids

Visible-Light-Mediated Decarboxylative Benzylation of Imines with Arylacetic Acids

A straightforward method for the visible-light-mediated decarboxylative benzylation of imines is reported. The key feature of this method is the use of simple primary, secondary, and tertiary arylacetic acids as precursors of benzyl radicals, enabling the facile benzylation of a variety of imines un...

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Veröffentlicht in:Journal of organic chemistry 2018-10, Vol.83 (20), p.12559-12567
Hauptverfasser: Guo, Jing, Wu, Qiao-Lei, Xie, Ying, Weng, Jiang, Lu, Gui
Format: Artikel
Sprache:eng
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Zusammenfassung:A straightforward method for the visible-light-mediated decarboxylative benzylation of imines is reported. The key feature of this method is the use of simple primary, secondary, and tertiary arylacetic acids as precursors of benzyl radicals, enabling the facile benzylation of a variety of imines under mild conditions. A variety of structurally diverse β-arylethylamines (37 examples) was accessed using this method.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b01849