Morpho‐Functional Characteristics of Bone Marrow Multipotent Mesenchymal Stromal Cells after Activation or Inhibition of Epidermal Growth Factor and Toll‐Like Receptors or Treatment with DNA Intercalator Cisplatin

This study is aimed to reveal morphological and functional changes in multipotent mesenchymal stromal cells (MSCs) isolated from the rat bone marrow after: (i) activation of Toll‐like receptors (TLRs) with teichoic acid (TA), (ii) impact on epidermal growth factor (EGF) receptors with activator EGF...

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Veröffentlicht in:	Cytometry. Part A 2019-01, Vol.95 (1), p.24-33
Hauptverfasser:	Golovynska, Iuliia, Kalmukova, Olesia, Svitina, Hanna M., Kyryk, Vitaliy M., Shablii, Volodimir A., Senchylo, Nataliya V., Ostrovska, Galyna V., Dzerzhinskyi, Mykola, Stepanov, Yurii V., Golovynskyi, Sergii, Ohulchanskyy, Tymish Y., Liu, Liwei, Garmanchuk, Liudmila V., Qu, Junle
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Bone marrow Bone Marrow Cells - chemistry Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Differentiation - drug effects Cell morphology Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Cisplatin Cisplatin - pharmacology Cytology Cytometry Cytoplasm c‐Myc Deoxyribonucleic acid DNA Epidermal growth factor Epidermal Growth Factor - pharmacology ErbB Receptors - agonists ErbB Receptors - antagonists & inhibitors Flow Cytometry G1 phase Glycogen - metabolism Glycosaminoglycans Glycosaminoglycans - biosynthesis Glycosaminoglycans - metabolism Growth factors Herceptin Humans Immune system immunocytochemistry Intercalating Agents - pharmacology Male Mesenchymal stem cells Mesenchymal Stem Cells - chemistry Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism mesenchymal–epithelial transition Mesenchyme Morphology multipotent mesenchymal stromal cell Myc protein Phenotypes Proteins Proto-Oncogene Proteins c-myc - metabolism Rats Receptors Stromal cells teichoic acid Teichoic Acids - pharmacology Toll-Like Receptors - metabolism Toll‐like receptor Trastuzumab - pharmacology
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