Effects of physical exercise during pregnancy on maternal and infant outcomes in overweight and obese pregnant women: A meta‐analysis
Background Overweight and obesity are related to maternal and infant physical health, such as gestational diabetes, preeclampsia, and macrosomia. The purpose of this meta‐analysis was to assess the effect of physical exercise on maternal and infant outcomes in overweight and obese pregnant women. Me...
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| Veröffentlicht in: | Birth (Berkeley, Calif.) Calif.), 2019-06, Vol.46 (2), p.211-221 |
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| creator | Du, Mei‐Chen Ouyang, Yan‐Qiong Nie, Xiao‐Fei Huang, Yi Redding, Sharon R. |
| description | Background
Overweight and obesity are related to maternal and infant physical health, such as gestational diabetes, preeclampsia, and macrosomia. The purpose of this meta‐analysis was to assess the effect of physical exercise on maternal and infant outcomes in overweight and obese pregnant women.
Methods
Two researchers independently searched Cochrane Library, Embase, PubMed, Web of Science, and ClinicalTrials.gov. for English‐language articles based on randomized controlled trials examining physical exercise in overweight and obese pregnant women and its effect on maternal and infant outcomes. Primary outcomes were gestational weight gain and a relative risk of gestational diabetes. Secondary outcomes were gestational hypertension, preeclampsia, cesarean delivery, birthweight, large for gestational age, small for gestational age, macrosomia, and preterm birth. Risk bias was evaluated by Cochrane Collaboration's tool. The results of integration were reported as relative risks (RR), mean difference, or standard mean difference with 95% confidence intervals (CI). This meta‐analysis was registered on PROSPERO on November 18, 2017, with registration number CRD42017081565.
Results
Thirteen studies involving 1439 participants were included. Physical exercise reduced gestational weight gain (mean difference = −1.14 kg, 95% CI = [−1.67 to −0.62], P |
| doi_str_mv | 10.1111/birt.12396 |
| format | Article |
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Overweight and obesity are related to maternal and infant physical health, such as gestational diabetes, preeclampsia, and macrosomia. The purpose of this meta‐analysis was to assess the effect of physical exercise on maternal and infant outcomes in overweight and obese pregnant women.
Methods
Two researchers independently searched Cochrane Library, Embase, PubMed, Web of Science, and ClinicalTrials.gov. for English‐language articles based on randomized controlled trials examining physical exercise in overweight and obese pregnant women and its effect on maternal and infant outcomes. Primary outcomes were gestational weight gain and a relative risk of gestational diabetes. Secondary outcomes were gestational hypertension, preeclampsia, cesarean delivery, birthweight, large for gestational age, small for gestational age, macrosomia, and preterm birth. Risk bias was evaluated by Cochrane Collaboration's tool. The results of integration were reported as relative risks (RR), mean difference, or standard mean difference with 95% confidence intervals (CI). This meta‐analysis was registered on PROSPERO on November 18, 2017, with registration number CRD42017081565.
Results
Thirteen studies involving 1439 participants were included. Physical exercise reduced gestational weight gain (mean difference = −1.14 kg, 95% CI = [−1.67 to −0.62], P < 0.0001) and the risk of gestational diabetes (RR = 0.71, 95% CI = [0.57‐0.89], P = 0.004) in overweight and obese pregnant women. There were no significant differences in other outcomes such as gestational hypertension, preeclampsia, cesarean delivery, birthweight, large for gestational age, small for gestational age, macrosomia, and preterm birth.
Conclusions
Prenatal exercise interventions reduced gestational weight gain and the risk of gestational diabetes for overweight and obese pregnant women, which reinforced the benefits of exercise during pregnancy. However, no evidence was found with respect to benefits and/or harm for infants. Consideration should be taken when interpreting these findings as a result of the relative small sample size in this meta‐analysis. Further larger well‐designed randomized trials may be helpful to assess the short‐term and long‐term effects of prenatal exercise on maternal and infant outcomes.</description><identifier>ISSN: 0730-7659</identifier><identifier>EISSN: 1523-536X</identifier><identifier>DOI: 10.1111/birt.12396</identifier><identifier>PMID: 30240042</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Bias ; Birth weight ; Blood pressure ; Cesarean section ; Childbirth & labor ; Clinical outcomes ; Clinical trials ; Confidence intervals ; Diabetes ; Diabetes, Gestational - prevention & control ; English language ; Evidence-based medicine ; Exercise ; Female ; Gestational Age ; Gestational diabetes ; Gestational Weight Gain ; Health status ; Humans ; Hypertension ; Infant Health ; infant health outcomes ; Infant, Newborn ; Infants ; Maternal & child health ; Maternal and infant welfare ; Maternal characteristics ; maternal health outcomes ; Medical research ; Meta-analysis ; Mothers ; Obesity ; Obesity - complications ; Obesity - therapy ; Overweight ; Overweight - complications ; Overweight - therapy ; overweight and obesity ; Preeclampsia ; Pregnancy ; Pregnancy Complications - prevention & control ; Pregnancy Outcome ; Premature birth ; Prenatal care ; Randomized Controlled Trials as Topic ; Risk ; Risk factors ; Weight gain ; Women ; Womens health</subject><ispartof>Birth (Berkeley, Calif.), 2019-06, Vol.46 (2), p.211-221</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>Copyright © 2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3576-e68029e9854c72f8e4a397387b121740344d54d786e46ffbb3dc3f19225343a03</citedby><cites>FETCH-LOGICAL-c3576-e68029e9854c72f8e4a397387b121740344d54d786e46ffbb3dc3f19225343a03</cites><orcidid>0000-0002-1562-1155</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbirt.12396$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbirt.12396$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,30976,33751,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30240042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Mei‐Chen</creatorcontrib><creatorcontrib>Ouyang, Yan‐Qiong</creatorcontrib><creatorcontrib>Nie, Xiao‐Fei</creatorcontrib><creatorcontrib>Huang, Yi</creatorcontrib><creatorcontrib>Redding, Sharon R.</creatorcontrib><title>Effects of physical exercise during pregnancy on maternal and infant outcomes in overweight and obese pregnant women: A meta‐analysis</title><title>Birth (Berkeley, Calif.)</title><addtitle>Birth</addtitle><description>Background
Overweight and obesity are related to maternal and infant physical health, such as gestational diabetes, preeclampsia, and macrosomia. The purpose of this meta‐analysis was to assess the effect of physical exercise on maternal and infant outcomes in overweight and obese pregnant women.
Methods
Two researchers independently searched Cochrane Library, Embase, PubMed, Web of Science, and ClinicalTrials.gov. for English‐language articles based on randomized controlled trials examining physical exercise in overweight and obese pregnant women and its effect on maternal and infant outcomes. Primary outcomes were gestational weight gain and a relative risk of gestational diabetes. Secondary outcomes were gestational hypertension, preeclampsia, cesarean delivery, birthweight, large for gestational age, small for gestational age, macrosomia, and preterm birth. Risk bias was evaluated by Cochrane Collaboration's tool. The results of integration were reported as relative risks (RR), mean difference, or standard mean difference with 95% confidence intervals (CI). This meta‐analysis was registered on PROSPERO on November 18, 2017, with registration number CRD42017081565.
Results
Thirteen studies involving 1439 participants were included. Physical exercise reduced gestational weight gain (mean difference = −1.14 kg, 95% CI = [−1.67 to −0.62], P < 0.0001) and the risk of gestational diabetes (RR = 0.71, 95% CI = [0.57‐0.89], P = 0.004) in overweight and obese pregnant women. There were no significant differences in other outcomes such as gestational hypertension, preeclampsia, cesarean delivery, birthweight, large for gestational age, small for gestational age, macrosomia, and preterm birth.
Conclusions
Prenatal exercise interventions reduced gestational weight gain and the risk of gestational diabetes for overweight and obese pregnant women, which reinforced the benefits of exercise during pregnancy. However, no evidence was found with respect to benefits and/or harm for infants. Consideration should be taken when interpreting these findings as a result of the relative small sample size in this meta‐analysis. Further larger well‐designed randomized trials may be helpful to assess the short‐term and long‐term effects of prenatal exercise on maternal and infant outcomes.</description><subject>Bias</subject><subject>Birth weight</subject><subject>Blood pressure</subject><subject>Cesarean section</subject><subject>Childbirth & labor</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Diabetes, Gestational - prevention & control</subject><subject>English language</subject><subject>Evidence-based medicine</subject><subject>Exercise</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gestational diabetes</subject><subject>Gestational Weight Gain</subject><subject>Health status</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infant Health</subject><subject>infant health outcomes</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Maternal & child health</subject><subject>Maternal and infant welfare</subject><subject>Maternal characteristics</subject><subject>maternal health outcomes</subject><subject>Medical research</subject><subject>Meta-analysis</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - therapy</subject><subject>Overweight</subject><subject>Overweight - complications</subject><subject>Overweight - therapy</subject><subject>overweight and obesity</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - prevention & control</subject><subject>Pregnancy Outcome</subject><subject>Premature birth</subject><subject>Prenatal care</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Weight gain</subject><subject>Women</subject><subject>Womens health</subject><issn>0730-7659</issn><issn>1523-536X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>BHHNA</sourceid><recordid>eNp90U1rFDEYwPEgFrtWL34ACXgphal5m2TGWy1VCwVBKngbMpkn25SZZE0ybvfWm1c_o5_EbHfrwYO5hMCPf0gehF5RckrLetu7mE8p4618gha0Zryqufz2FC2I4qRSsm4P0fOUbgkhSgj5DB1ywgQhgi3QzwtrweSEg8Wrm01yRo8Y7iAalwAPc3R-iVcRll57s8HB40lniL4o7QfsvNU-4zBnEyZI5YzDD4hrcMub_CBCDyW0L2S8Lsy_w2d4gqx_3__SpVRuTS_QgdVjgpf7_Qh9_XBxff6puvr88fL87KoyvFayAtkQ1kLb1MIoZhsQmreKN6qnjCpBuBBDLQbVSBDS2r7ng-GWtozVXHBN-BE63nVXMXyfIeVucsnAOGoPYU4d2_5oTYVihb75h96GefvyohiTsvy04kWd7JSJIaUItltFN-m46SjptrFuO57uYTwFv94n536C4S99nEcBdAfWboTNf1Ld-8sv17voH4Ctm-o</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Du, Mei‐Chen</creator><creator>Ouyang, Yan‐Qiong</creator><creator>Nie, Xiao‐Fei</creator><creator>Huang, Yi</creator><creator>Redding, Sharon R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7U3</scope><scope>ASE</scope><scope>BHHNA</scope><scope>FPQ</scope><scope>K6X</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1562-1155</orcidid></search><sort><creationdate>201906</creationdate><title>Effects of physical exercise during pregnancy on maternal and infant outcomes in overweight and obese pregnant women: A meta‐analysis</title><author>Du, Mei‐Chen ; Ouyang, Yan‐Qiong ; Nie, Xiao‐Fei ; Huang, Yi ; Redding, Sharon R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-e68029e9854c72f8e4a397387b121740344d54d786e46ffbb3dc3f19225343a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bias</topic><topic>Birth weight</topic><topic>Blood pressure</topic><topic>Cesarean section</topic><topic>Childbirth & labor</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Confidence intervals</topic><topic>Diabetes</topic><topic>Diabetes, Gestational - prevention & control</topic><topic>English language</topic><topic>Evidence-based medicine</topic><topic>Exercise</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gestational diabetes</topic><topic>Gestational Weight Gain</topic><topic>Health status</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Infant Health</topic><topic>infant health outcomes</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Maternal & child health</topic><topic>Maternal and infant welfare</topic><topic>Maternal characteristics</topic><topic>maternal health outcomes</topic><topic>Medical research</topic><topic>Meta-analysis</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - therapy</topic><topic>Overweight</topic><topic>Overweight - complications</topic><topic>Overweight - therapy</topic><topic>overweight and obesity</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - prevention & control</topic><topic>Pregnancy Outcome</topic><topic>Premature birth</topic><topic>Prenatal care</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Weight gain</topic><topic>Women</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Mei‐Chen</creatorcontrib><creatorcontrib>Ouyang, Yan‐Qiong</creatorcontrib><creatorcontrib>Nie, Xiao‐Fei</creatorcontrib><creatorcontrib>Huang, Yi</creatorcontrib><creatorcontrib>Redding, Sharon R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Social Services Abstracts</collection><collection>British Nursing Index</collection><collection>Sociological Abstracts</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Birth (Berkeley, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Mei‐Chen</au><au>Ouyang, Yan‐Qiong</au><au>Nie, Xiao‐Fei</au><au>Huang, Yi</au><au>Redding, Sharon R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of physical exercise during pregnancy on maternal and infant outcomes in overweight and obese pregnant women: A meta‐analysis</atitle><jtitle>Birth (Berkeley, Calif.)</jtitle><addtitle>Birth</addtitle><date>2019-06</date><risdate>2019</risdate><volume>46</volume><issue>2</issue><spage>211</spage><epage>221</epage><pages>211-221</pages><issn>0730-7659</issn><eissn>1523-536X</eissn><abstract>Background
Overweight and obesity are related to maternal and infant physical health, such as gestational diabetes, preeclampsia, and macrosomia. The purpose of this meta‐analysis was to assess the effect of physical exercise on maternal and infant outcomes in overweight and obese pregnant women.
Methods
Two researchers independently searched Cochrane Library, Embase, PubMed, Web of Science, and ClinicalTrials.gov. for English‐language articles based on randomized controlled trials examining physical exercise in overweight and obese pregnant women and its effect on maternal and infant outcomes. Primary outcomes were gestational weight gain and a relative risk of gestational diabetes. Secondary outcomes were gestational hypertension, preeclampsia, cesarean delivery, birthweight, large for gestational age, small for gestational age, macrosomia, and preterm birth. Risk bias was evaluated by Cochrane Collaboration's tool. The results of integration were reported as relative risks (RR), mean difference, or standard mean difference with 95% confidence intervals (CI). This meta‐analysis was registered on PROSPERO on November 18, 2017, with registration number CRD42017081565.
Results
Thirteen studies involving 1439 participants were included. Physical exercise reduced gestational weight gain (mean difference = −1.14 kg, 95% CI = [−1.67 to −0.62], P < 0.0001) and the risk of gestational diabetes (RR = 0.71, 95% CI = [0.57‐0.89], P = 0.004) in overweight and obese pregnant women. There were no significant differences in other outcomes such as gestational hypertension, preeclampsia, cesarean delivery, birthweight, large for gestational age, small for gestational age, macrosomia, and preterm birth.
Conclusions
Prenatal exercise interventions reduced gestational weight gain and the risk of gestational diabetes for overweight and obese pregnant women, which reinforced the benefits of exercise during pregnancy. However, no evidence was found with respect to benefits and/or harm for infants. Consideration should be taken when interpreting these findings as a result of the relative small sample size in this meta‐analysis. Further larger well‐designed randomized trials may be helpful to assess the short‐term and long‐term effects of prenatal exercise on maternal and infant outcomes.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30240042</pmid><doi>10.1111/birt.12396</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1562-1155</orcidid></addata></record> |
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| ispartof | Birth (Berkeley, Calif.), 2019-06, Vol.46 (2), p.211-221 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Wiley Online Library Journals Frontfile Complete; Sociological Abstracts |
| subjects | Bias Birth weight Blood pressure Cesarean section Childbirth & labor Clinical outcomes Clinical trials Confidence intervals Diabetes Diabetes, Gestational - prevention & control English language Evidence-based medicine Exercise Female Gestational Age Gestational diabetes Gestational Weight Gain Health status Humans Hypertension Infant Health infant health outcomes Infant, Newborn Infants Maternal & child health Maternal and infant welfare Maternal characteristics maternal health outcomes Medical research Meta-analysis Mothers Obesity Obesity - complications Obesity - therapy Overweight Overweight - complications Overweight - therapy overweight and obesity Preeclampsia Pregnancy Pregnancy Complications - prevention & control Pregnancy Outcome Premature birth Prenatal care Randomized Controlled Trials as Topic Risk Risk factors Weight gain Women Womens health |
| title | Effects of physical exercise during pregnancy on maternal and infant outcomes in overweight and obese pregnant women: A meta‐analysis |
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