Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice

Background/Aims: Fisetin is a naturally abundant flavonoid isolated from various fruits and vegetables that was recently identified to have potential biological functions in improving allergic airway inflammation, as well as anti-oxidative and anti-tumor properties. Fisetin has also been demonstrate...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.49 (5), p.1870-1884
Hauptverfasser:	Liou, Chian-Jiun, Wei, Ciao-Han, Chen, Ya-Ling, Cheng, Ching-Yi, Wang, Chia-Ling, Huang, Wen-Chung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose Tissue - pathology AMP-Activated Protein Kinases - metabolism AMPK Animals Autophagy Biosynthesis Cell Line Cell Survival - drug effects CPT-1 Decomposition Diabetes Diet, High-Fat Energy Fatty acids Fatty Acids - metabolism Fisetin FL83B Flavonoids - pharmacology Flavonoids - therapeutic use Food Gene expression Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Kinases Laboratory animals Lipid Metabolism - drug effects Lipid Peroxidation - drug effects Lipids Lipolysis Liver diseases Male Metabolism Mice Mice, Inbred C57BL Mice, Obese Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Nonalcoholic fatty liver disease Obesity Obesity - pathology Obesity - prevention & control Original Paper Phosphorylation Protective Agents - pharmacology Protective Agents - therapeutic use Proteins Signal Transduction - drug effects Sirtuin 1 - metabolism Sterols Systematic review Transcription factors
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