Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin

The extent to which early events shape tumor evolution is largely uncharacterized, even though a better understanding of these early events may help identify key vulnerabilities in advanced tumors. Here, using genetically defined mouse models of small cell lung cancer (SCLC), we uncovered distinct m...

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Veröffentlicht in:	Cancer discovery 2018-10, Vol.8 (10), p.1316-1331
Hauptverfasser:	Yang, Dian, Denny, Sarah K, Greenside, Peyton G, Chaikovsky, Andrea C, Brady, Jennifer J, Ouadah, Youcef, Granja, Jeffrey M, Jahchan, Nadine S, Lim, Jing Shan, Kwok, Shirley, Kong, Christina S, Berghoff, Anna S, Schmitt, Anna, Reinhardt, H Christian, Park, Kwon-Sik, Preusser, Matthias, Kundaje, Anshul, Greenleaf, William J, Sage, Julien, Winslow, Monte M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Disease Models, Animal Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Mice Small Cell Lung Carcinoma - genetics Small Cell Lung Carcinoma - pathology
Online-Zugang:	Volltext
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