Galangin inhibits α-glucosidase activity and formation of non-enzymatic glycation products

[Display omitted] •Galangin reversibly inhibits α-glucosidase in a mixed-type manner.•Galangin binds to the active site of α-glucosidase and induces its conformational change.•The binding is mainly driven by hydrophobic interaction and hydrogen bonds.•Galangin strongly inhibits the formation of adva...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Food chemistry 2019-01, Vol.271, p.70-79
Hauptverfasser:	Zeng, Li, Ding, Huafang, Hu, Xing, Zhang, Guowen, Gong, Deming
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Glucosidases - drug effects alpha-Glucosidases - metabolism Diabetes Mellitus, Type 2 Flavonoids - pharmacology Galangin Glycation End Products, Advanced - chemical synthesis Glycoside Hydrolase Inhibitors - pharmacology Humans Kinetics Mechanism of α-glucosidase inhibition Molecular Docking Simulation Non-enzymatic glycation α-Glucosidase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!