Role of angiotensin‐converting enzyme insertion/deletion polymorphism in sudden cardiac arrest
Objective This study aimed to investigate the relationship between angiotensin‐converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population. Methods In this study, 232 patients were divided into the SCA group and the coronary d...
Gespeichert in:
| Veröffentlicht in: | Journal of cellular biochemistry 2019-03, Vol.120 (3), p.3474-3478 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3478 |
|---|---|
| container_issue | 3 |
| container_start_page | 3474 |
| container_title | Journal of cellular biochemistry |
| container_volume | 120 |
| creator | Liu, Aifen Wang, Sai Zhang, Chunxiao Sun, Di Song, Xiaozheng |
| description | Objective
This study aimed to investigate the relationship between angiotensin‐converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population.
Methods
In this study, 232 patients were divided into the SCA group and the coronary disease group with coronary disease, but no SCA occurred during the treatment period. After comparing the genotype frequencies of the two groups, all patients were further divided into three groups as the II homozygotes, ID heterozygotes, and DD homozygotes to investigate the relationship in ACE I/D polymorphism and other risk factors of SCA.
Results
The frequencies of DD genotype in the SCA group were significantly higher than the coronary disease group, as well as the D allele frequencies in the SCA group were high when compared with the coronary disease group. According to the genotypes of the ACE I/D polymorphism, the distribution of patients’ characteristics had no significant differences among all the characteristics. Both, the patients who survived SCA, with II genotype and the ones who died of SCA, with DD genotype had significant higher percentages.
Conclusion
The DD genotype was associated with a higher prevalence of SCA and might be a risk factor of survival rate in sudden cardiac death. |
| doi_str_mv | 10.1002/jcb.27622 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2111142882</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2167054647</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3132-6fb2e72d117ed55eae41e23e954431e0f576b212817d5505bbc19a6f10b734833</originalsourceid><addsrcrecordid>eNp1kE1OwzAQRi0EglJYcAEUiQ0s0trjJG6WUPGrSkgI1sFJJsVVYhe7AYUVR-CMnASXFhZIzMYjz9M39iPkgNEBoxSGsyIfgEgANkiP0VSEURJFm6RHBachcAY7ZNe5GaU0TTlskx1OIYJRSnvk8c7UGJgqkHqqzAK1U_rz_aMw-gXtQulpgPqtazBQ2i0vjB6WWOOyCeam7hpj50_KNX4euLYsUQeFtKWSRSCtRbfYI1uVrB3ur88-ebg4vx9fhZPby-vx6SQsOOMQJlUOKKBkTGAZxygxYggc0ziKOENaxSLJgcGICT-mcZ4XLJVJxWgueDTivE-OV7lza55bvzhrlCuwrqVG07oMmC__6RF49OgPOjOt1f51nkoEjb0-4amTFVVY45zFKptb1UjbZYxmS-2Z1559a_fs4TqxzRssf8kfzx4YroBXVWP3f1J2Mz5bRX4BLA6M0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2167054647</pqid></control><display><type>article</type><title>Role of angiotensin‐converting enzyme insertion/deletion polymorphism in sudden cardiac arrest</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Liu, Aifen ; Wang, Sai ; Zhang, Chunxiao ; Sun, Di ; Song, Xiaozheng</creator><creatorcontrib>Liu, Aifen ; Wang, Sai ; Zhang, Chunxiao ; Sun, Di ; Song, Xiaozheng</creatorcontrib><description>Objective
This study aimed to investigate the relationship between angiotensin‐converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population.
Methods
In this study, 232 patients were divided into the SCA group and the coronary disease group with coronary disease, but no SCA occurred during the treatment period. After comparing the genotype frequencies of the two groups, all patients were further divided into three groups as the II homozygotes, ID heterozygotes, and DD homozygotes to investigate the relationship in ACE I/D polymorphism and other risk factors of SCA.
Results
The frequencies of DD genotype in the SCA group were significantly higher than the coronary disease group, as well as the D allele frequencies in the SCA group were high when compared with the coronary disease group. According to the genotypes of the ACE I/D polymorphism, the distribution of patients’ characteristics had no significant differences among all the characteristics. Both, the patients who survived SCA, with II genotype and the ones who died of SCA, with DD genotype had significant higher percentages.
Conclusion
The DD genotype was associated with a higher prevalence of SCA and might be a risk factor of survival rate in sudden cardiac death.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.27622</identifier><identifier>PMID: 30242890</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Angiotensin ; angiotensin‐converting enzyme ; Cardiac arrest ; Cardiopulmonary resuscitation ; Conversion ; CPR ; Defibrillators ; Enzymes ; Gene deletion ; Gene frequency ; Gene polymorphism ; Genotype & phenotype ; Genotypes ; Heart diseases ; Heart rate ; Heterozygotes ; Homozygotes ; Insertion ; insertion/deletion polymorphism ; Patients ; Polymorphism ; Population studies ; Risk analysis ; Risk factors ; sudden cardiac arrest ; Survival</subject><ispartof>Journal of cellular biochemistry, 2019-03, Vol.120 (3), p.3474-3478</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3132-6fb2e72d117ed55eae41e23e954431e0f576b212817d5505bbc19a6f10b734833</cites><orcidid>0000-0002-1792-2402</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.27622$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.27622$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30242890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Aifen</creatorcontrib><creatorcontrib>Wang, Sai</creatorcontrib><creatorcontrib>Zhang, Chunxiao</creatorcontrib><creatorcontrib>Sun, Di</creatorcontrib><creatorcontrib>Song, Xiaozheng</creatorcontrib><title>Role of angiotensin‐converting enzyme insertion/deletion polymorphism in sudden cardiac arrest</title><title>Journal of cellular biochemistry</title><addtitle>J Cell Biochem</addtitle><description>Objective
This study aimed to investigate the relationship between angiotensin‐converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population.
Methods
In this study, 232 patients were divided into the SCA group and the coronary disease group with coronary disease, but no SCA occurred during the treatment period. After comparing the genotype frequencies of the two groups, all patients were further divided into three groups as the II homozygotes, ID heterozygotes, and DD homozygotes to investigate the relationship in ACE I/D polymorphism and other risk factors of SCA.
Results
The frequencies of DD genotype in the SCA group were significantly higher than the coronary disease group, as well as the D allele frequencies in the SCA group were high when compared with the coronary disease group. According to the genotypes of the ACE I/D polymorphism, the distribution of patients’ characteristics had no significant differences among all the characteristics. Both, the patients who survived SCA, with II genotype and the ones who died of SCA, with DD genotype had significant higher percentages.
Conclusion
The DD genotype was associated with a higher prevalence of SCA and might be a risk factor of survival rate in sudden cardiac death.</description><subject>Angiotensin</subject><subject>angiotensin‐converting enzyme</subject><subject>Cardiac arrest</subject><subject>Cardiopulmonary resuscitation</subject><subject>Conversion</subject><subject>CPR</subject><subject>Defibrillators</subject><subject>Enzymes</subject><subject>Gene deletion</subject><subject>Gene frequency</subject><subject>Gene polymorphism</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Heart diseases</subject><subject>Heart rate</subject><subject>Heterozygotes</subject><subject>Homozygotes</subject><subject>Insertion</subject><subject>insertion/deletion polymorphism</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Population studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>sudden cardiac arrest</subject><subject>Survival</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kE1OwzAQRi0EglJYcAEUiQ0s0trjJG6WUPGrSkgI1sFJJsVVYhe7AYUVR-CMnASXFhZIzMYjz9M39iPkgNEBoxSGsyIfgEgANkiP0VSEURJFm6RHBachcAY7ZNe5GaU0TTlskx1OIYJRSnvk8c7UGJgqkHqqzAK1U_rz_aMw-gXtQulpgPqtazBQ2i0vjB6WWOOyCeam7hpj50_KNX4euLYsUQeFtKWSRSCtRbfYI1uVrB3ur88-ebg4vx9fhZPby-vx6SQsOOMQJlUOKKBkTGAZxygxYggc0ziKOENaxSLJgcGICT-mcZ4XLJVJxWgueDTivE-OV7lza55bvzhrlCuwrqVG07oMmC__6RF49OgPOjOt1f51nkoEjb0-4amTFVVY45zFKptb1UjbZYxmS-2Z1559a_fs4TqxzRssf8kfzx4YroBXVWP3f1J2Mz5bRX4BLA6M0g</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Liu, Aifen</creator><creator>Wang, Sai</creator><creator>Zhang, Chunxiao</creator><creator>Sun, Di</creator><creator>Song, Xiaozheng</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1792-2402</orcidid></search><sort><creationdate>201903</creationdate><title>Role of angiotensin‐converting enzyme insertion/deletion polymorphism in sudden cardiac arrest</title><author>Liu, Aifen ; Wang, Sai ; Zhang, Chunxiao ; Sun, Di ; Song, Xiaozheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3132-6fb2e72d117ed55eae41e23e954431e0f576b212817d5505bbc19a6f10b734833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Angiotensin</topic><topic>angiotensin‐converting enzyme</topic><topic>Cardiac arrest</topic><topic>Cardiopulmonary resuscitation</topic><topic>Conversion</topic><topic>CPR</topic><topic>Defibrillators</topic><topic>Enzymes</topic><topic>Gene deletion</topic><topic>Gene frequency</topic><topic>Gene polymorphism</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Heart diseases</topic><topic>Heart rate</topic><topic>Heterozygotes</topic><topic>Homozygotes</topic><topic>Insertion</topic><topic>insertion/deletion polymorphism</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Population studies</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>sudden cardiac arrest</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Aifen</creatorcontrib><creatorcontrib>Wang, Sai</creatorcontrib><creatorcontrib>Zhang, Chunxiao</creatorcontrib><creatorcontrib>Sun, Di</creatorcontrib><creatorcontrib>Song, Xiaozheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Aifen</au><au>Wang, Sai</au><au>Zhang, Chunxiao</au><au>Sun, Di</au><au>Song, Xiaozheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of angiotensin‐converting enzyme insertion/deletion polymorphism in sudden cardiac arrest</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J Cell Biochem</addtitle><date>2019-03</date><risdate>2019</risdate><volume>120</volume><issue>3</issue><spage>3474</spage><epage>3478</epage><pages>3474-3478</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>Objective
This study aimed to investigate the relationship between angiotensin‐converting enzyme (ACE) insertion/deletion (I/D) polymorphism and to understand sudden cardiac arrest (SCA) in the Chinese population.
Methods
In this study, 232 patients were divided into the SCA group and the coronary disease group with coronary disease, but no SCA occurred during the treatment period. After comparing the genotype frequencies of the two groups, all patients were further divided into three groups as the II homozygotes, ID heterozygotes, and DD homozygotes to investigate the relationship in ACE I/D polymorphism and other risk factors of SCA.
Results
The frequencies of DD genotype in the SCA group were significantly higher than the coronary disease group, as well as the D allele frequencies in the SCA group were high when compared with the coronary disease group. According to the genotypes of the ACE I/D polymorphism, the distribution of patients’ characteristics had no significant differences among all the characteristics. Both, the patients who survived SCA, with II genotype and the ones who died of SCA, with DD genotype had significant higher percentages.
Conclusion
The DD genotype was associated with a higher prevalence of SCA and might be a risk factor of survival rate in sudden cardiac death.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30242890</pmid><doi>10.1002/jcb.27622</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1792-2402</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0730-2312 |
| ispartof | Journal of cellular biochemistry, 2019-03, Vol.120 (3), p.3474-3478 |
| issn | 0730-2312 1097-4644 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2111142882 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Angiotensin angiotensin‐converting enzyme Cardiac arrest Cardiopulmonary resuscitation Conversion CPR Defibrillators Enzymes Gene deletion Gene frequency Gene polymorphism Genotype & phenotype Genotypes Heart diseases Heart rate Heterozygotes Homozygotes Insertion insertion/deletion polymorphism Patients Polymorphism Population studies Risk analysis Risk factors sudden cardiac arrest Survival |
| title | Role of angiotensin‐converting enzyme insertion/deletion polymorphism in sudden cardiac arrest |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T20%3A08%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20angiotensin%E2%80%90converting%20enzyme%20insertion/deletion%20polymorphism%20in%20sudden%20cardiac%20arrest&rft.jtitle=Journal%20of%20cellular%20biochemistry&rft.au=Liu,%20Aifen&rft.date=2019-03&rft.volume=120&rft.issue=3&rft.spage=3474&rft.epage=3478&rft.pages=3474-3478&rft.issn=0730-2312&rft.eissn=1097-4644&rft_id=info:doi/10.1002/jcb.27622&rft_dat=%3Cproquest_cross%3E2167054647%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2167054647&rft_id=info:pmid/30242890&rfr_iscdi=true |