SM22α inhibits cell proliferation and protects against anticancer drugs and γ-radiation in HepG2 cells: Involvement of metallothioneins

SM22α inhibits cell proliferation and protects against anticancer drugs and γ-radiation in HepG2 cells: Involvement of metallothioneins

Smooth muscle protein 22-alpha (SM22α) has been postulated to affect the structure and function of the actin filament. In this study, we report on the significant induction of SM22α by cytotoxic agents in HepG2 cells. SM22α-overexpression inhibited the activation of IGF-1Rβ/Akt and Erk, consequently...

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Veröffentlicht in:FEBS letters 2009-10, Vol.583 (20), p.3356-3362
Hauptverfasser: Kim, Tae Rim, Moon, Ji Hye, Lee, Hee Min, Cho, Eun Wie, Paik, Sang Gi, Kim, In Gyu
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Sprache:eng
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Cytotoxic drug
IGF-1Rβ/Akt
Luteolin
Metallothionein
SM22α
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container_end_page 3362
container_issue 20
container_start_page 3356
container_title FEBS letters
container_volume 583
creator Kim, Tae Rim
Moon, Ji Hye
Lee, Hee Min
Cho, Eun Wie
Paik, Sang Gi
Kim, In Gyu
description Smooth muscle protein 22-alpha (SM22α) has been postulated to affect the structure and function of the actin filament. In this study, we report on the significant induction of SM22α by cytotoxic agents in HepG2 cells. SM22α-overexpression inhibited the activation of IGF-1Rβ/Akt and Erk, consequently suppressing cell proliferation. On the other hand, SM22α-overexpressing cells became resistant to apoptotic cell death caused by cytotoxic agents, in which metallothionein (MT) isoforms, especially MT1G, were significantly induced. MT1G-overexpression also conferred cellular resistance, and SM22α regulated the expression of MT1G at a transcriptional level. This study provides the first demonstration of SM22α-induced blockage of cell proliferation and cellular resistance to overcome the detrimental effects of damaging agents.
doi_str_mv 10.1016/j.febslet.2009.09.040
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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; ScienceDirect Journals (5 years ago - present); Wiley Online Library All Journals; Alma/SFX Local Collection
subjects Cytotoxic drug
IGF-1Rβ/Akt
Luteolin
Metallothionein
SM22α
title SM22α inhibits cell proliferation and protects against anticancer drugs and γ-radiation in HepG2 cells: Involvement of metallothioneins
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