The organotin compounds trimethyltin (TMT) and triethyltin (TET) but not tributyltin (TBT) induce activation of microglia co-cultivated with astrocytes

The organotin compounds trimethyltin (TMT), triethyltin (TET) and tributyltin (TBT) show different organotoxicities in vivo. While TMT and TET induce a strong neurotoxicity accompanied by microglial and astroglial activation, TBT rather effects the immune system. Previously, we have shown in an in v...

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Veröffentlicht in:	Toxicology in vitro 2009-12, Vol.23 (8), p.1541-1547
Hauptverfasser:	Röhl, C., Grell, M., Maser, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - drug effects Cell interactions Cells, Cultured Coculture Techniques Dose-Response Relationship, Drug Inflammation Microglia Microglia - drug effects Neurotoxicity Nitric Oxide - biosynthesis Organotin compounds Rats Rats, Wistar Trialkyltin Compounds - toxicity Triethyltin Compounds - toxicity Trimethyltin Compounds - toxicity
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