A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man

This paper describes control of normal Leydig cell func tion and testosterone production. The macroscopic and histopathological appearances of spontaneous Leydig cell hyperplasias and tumors (LCT) in the rat are reviewed together with their incidence and hormonal status. Drugs which induce LCTs in c...

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Veröffentlicht in:	Human & Experimental Toxicology 1995-07, Vol.14 (7), p.562-572
Hauptverfasser:	Prentice, DE, Meikle, AW
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Disease Models, Animal Drug toxicity and drugs side effects treatment Humans Hyperplasia Leydig Cell Tumor - chemically induced Leydig Cells - drug effects Leydig Cells - pathology Male Medical sciences Pharmacology. Drug treatments Rats Testicular Neoplasms - chemically induced Toxicity: urogenital system
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