A Single Amino Acid of Toll-like Receptor 4 That Is Pivotal for Its Signal Transduction and Subcellular Localization

Toll-like receptor 4 (TLR4) is essential for recognizing a Gram-negative bacterial component, lipopolysaccharide (LPS). A single amino acid mutation at position 712 of murine TLR4 leads to hyporesponsiveness to LPS. In this study we determined that an amino acid, a leucine at position 815 of human T...

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Veröffentlicht in:	The Journal of biological chemistry 2009-02, Vol.284 (6), p.3513-3520
Hauptverfasser:	Yanagimoto, Shintaro, Tatsuno, Keita, Okugawa, Shu, Kitazawa, Takatoshi, Tsukada, Kunihisa, Koike, Kazuhiko, Kodama, Tatsuhiko, Kimura, Satoshi, Shibasaki, Yoshikazu, Ota, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acid Substitution Amino acids Animals Cell Line Cell Membrane - genetics Cell Membrane - metabolism Humans Leucine Lipopolysaccharides Lipopolysaccharides - metabolism Lymphocyte Antigen 96 - genetics Lymphocyte Antigen 96 - metabolism Mice Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Mutation Mutation, Missense Plasma membranes Protein Binding - physiology Protein Transport - physiology Signal transduction TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors
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