The Need for a Control Animal Pathology Database: An International Survey
1 The sensitivity of long-term toxicity tests is impaired due to the 'background noise' of spontaneous lesions which are unrelated to treatment. 2 The need for a comprehensive source of computerized information concerning the occurrence and incidence of spontaneous lesions in control anima...
Gespeichert in:
| Veröffentlicht in: | Human & experimental toxicology 1991-05, Vol.10 (3), p.205-213 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 213 |
|---|---|
| container_issue | 3 |
| container_start_page | 205 |
| container_title | Human & experimental toxicology |
| container_volume | 10 |
| creator | McAuslane, J.A.N. Lumley, C.E. Walker, S.R. |
| description | 1 The sensitivity of long-term toxicity tests is impaired due to the 'background noise' of spontaneous lesions which are unrelated to treatment.
2 The need for a comprehensive source of computerized information concerning the occurrence and incidence of spontaneous lesions in control animals has been highlighted by initiatives in Europe and the USA. It is, however, essential to identify the potential users, and the type of information required for such a database to be of value.
3 This information has been acquired following an international survey of the pharmaceutical industry in Europe, Japan and the USA, including responses from 48 toxicologists and toxicopathologists representing 38 company groups.
4 Thirty-eight respondents indicated that they would use a historical control database that was regularly updated with the majority of respondents suggesting that they currently use external sources (Breeder's data, the literature, other companies) occasionally to acquire information on control animal pathology data.
5 The majority (94%) of the respondents indicated that a control animal database should contain information on both neoplastic and non-neoplastic lesions for use in evaluating long-term studies, in particular carcinogenicity studies.
6 The survey confirms the need for a historical control animal pathology database wider then those currently available. |
| doi_str_mv | 10.1177/096032719101000310 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_21098056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_096032719101000310</sage_id><sourcerecordid>21098056</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-f398950bdc092843995bdc21a0b871010d69c458231b93a4484ad59189756dc43</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMoc07_gCDkRu_qTpq0abwb82swVHBelzRN90HWzKQV9u9N6WAXglfncN7nnJfzInRN4J4QzscgUqAxJ4IAAQBK4AQNCeM8AgH0FA07IOqIc3Th_SYwqUjIAA1IyrPQDdFssdL4TesSV9Zhiae2bpw1eFKvt9LgD9msrLHLPX6UjSyk1w9BwrO60a6WzdrWAfps3Y_eX6KzShqvrw51hL6enxbT12j-_jKbTuaRokI0UUVFcIaiVCDijIVZEvqYSCgy3v1RpkKxJIspKQSVjGVMlokgmeBJWipGR-iuv7tz9rvVvsm3a6-0MbLWtvV5TEBkkKQBjHtQOeu901W-c-Ept88J5F1--d_8wtLN4XpbbHV5XOkDC_rtQZdeSVM5Wau1P2KCp4wnPHDjnvNyqfONbUNcxv_n_Avzp4H1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21098056</pqid></control><display><type>article</type><title>The Need for a Control Animal Pathology Database: An International Survey</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><source>Alma/SFX Local Collection</source><creator>McAuslane, J.A.N. ; Lumley, C.E. ; Walker, S.R.</creator><creatorcontrib>McAuslane, J.A.N. ; Lumley, C.E. ; Walker, S.R.</creatorcontrib><description>1 The sensitivity of long-term toxicity tests is impaired due to the 'background noise' of spontaneous lesions which are unrelated to treatment.
2 The need for a comprehensive source of computerized information concerning the occurrence and incidence of spontaneous lesions in control animals has been highlighted by initiatives in Europe and the USA. It is, however, essential to identify the potential users, and the type of information required for such a database to be of value.
3 This information has been acquired following an international survey of the pharmaceutical industry in Europe, Japan and the USA, including responses from 48 toxicologists and toxicopathologists representing 38 company groups.
4 Thirty-eight respondents indicated that they would use a historical control database that was regularly updated with the majority of respondents suggesting that they currently use external sources (Breeder's data, the literature, other companies) occasionally to acquire information on control animal pathology data.
5 The majority (94%) of the respondents indicated that a control animal database should contain information on both neoplastic and non-neoplastic lesions for use in evaluating long-term studies, in particular carcinogenicity studies.
6 The survey confirms the need for a historical control animal pathology database wider then those currently available.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719101000310</identifier><identifier>PMID: 1678951</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Carcinogenicity Tests ; Databases, Factual ; Dogs ; Europe ; General aspects. Methods ; International Cooperation ; Japan ; Macaca fascicularis ; Medical sciences ; Mice ; Pathology ; Rats ; Rats, Inbred F344 ; Rats, Inbred Strains ; Surveys and Questionnaires ; Toxicology ; United States</subject><ispartof>Human & experimental toxicology, 1991-05, Vol.10 (3), p.205-213</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-f398950bdc092843995bdc21a0b871010d69c458231b93a4484ad59189756dc43</citedby><cites>FETCH-LOGICAL-c399t-f398950bdc092843995bdc21a0b871010d69c458231b93a4484ad59189756dc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719101000310$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719101000310$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,777,781,21800,27905,27906,43602,43603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19764757$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1678951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McAuslane, J.A.N.</creatorcontrib><creatorcontrib>Lumley, C.E.</creatorcontrib><creatorcontrib>Walker, S.R.</creatorcontrib><title>The Need for a Control Animal Pathology Database: An International Survey</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>1 The sensitivity of long-term toxicity tests is impaired due to the 'background noise' of spontaneous lesions which are unrelated to treatment.
2 The need for a comprehensive source of computerized information concerning the occurrence and incidence of spontaneous lesions in control animals has been highlighted by initiatives in Europe and the USA. It is, however, essential to identify the potential users, and the type of information required for such a database to be of value.
3 This information has been acquired following an international survey of the pharmaceutical industry in Europe, Japan and the USA, including responses from 48 toxicologists and toxicopathologists representing 38 company groups.
4 Thirty-eight respondents indicated that they would use a historical control database that was regularly updated with the majority of respondents suggesting that they currently use external sources (Breeder's data, the literature, other companies) occasionally to acquire information on control animal pathology data.
5 The majority (94%) of the respondents indicated that a control animal database should contain information on both neoplastic and non-neoplastic lesions for use in evaluating long-term studies, in particular carcinogenicity studies.
6 The survey confirms the need for a historical control animal pathology database wider then those currently available.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenicity Tests</subject><subject>Databases, Factual</subject><subject>Dogs</subject><subject>Europe</subject><subject>General aspects. Methods</subject><subject>International Cooperation</subject><subject>Japan</subject><subject>Macaca fascicularis</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pathology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Strains</subject><subject>Surveys and Questionnaires</subject><subject>Toxicology</subject><subject>United States</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoc07_gCDkRu_qTpq0abwb82swVHBelzRN90HWzKQV9u9N6WAXglfncN7nnJfzInRN4J4QzscgUqAxJ4IAAQBK4AQNCeM8AgH0FA07IOqIc3Th_SYwqUjIAA1IyrPQDdFssdL4TesSV9Zhiae2bpw1eFKvt9LgD9msrLHLPX6UjSyk1w9BwrO60a6WzdrWAfps3Y_eX6KzShqvrw51hL6enxbT12j-_jKbTuaRokI0UUVFcIaiVCDijIVZEvqYSCgy3v1RpkKxJIspKQSVjGVMlokgmeBJWipGR-iuv7tz9rvVvsm3a6-0MbLWtvV5TEBkkKQBjHtQOeu901W-c-Ept88J5F1--d_8wtLN4XpbbHV5XOkDC_rtQZdeSVM5Wau1P2KCp4wnPHDjnvNyqfONbUNcxv_n_Avzp4H1</recordid><startdate>19910501</startdate><enddate>19910501</enddate><creator>McAuslane, J.A.N.</creator><creator>Lumley, C.E.</creator><creator>Walker, S.R.</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19910501</creationdate><title>The Need for a Control Animal Pathology Database: An International Survey</title><author>McAuslane, J.A.N. ; Lumley, C.E. ; Walker, S.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-f398950bdc092843995bdc21a0b871010d69c458231b93a4484ad59189756dc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenicity Tests</topic><topic>Databases, Factual</topic><topic>Dogs</topic><topic>Europe</topic><topic>General aspects. Methods</topic><topic>International Cooperation</topic><topic>Japan</topic><topic>Macaca fascicularis</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pathology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Strains</topic><topic>Surveys and Questionnaires</topic><topic>Toxicology</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McAuslane, J.A.N.</creatorcontrib><creatorcontrib>Lumley, C.E.</creatorcontrib><creatorcontrib>Walker, S.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McAuslane, J.A.N.</au><au>Lumley, C.E.</au><au>Walker, S.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Need for a Control Animal Pathology Database: An International Survey</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1991-05-01</date><risdate>1991</risdate><volume>10</volume><issue>3</issue><spage>205</spage><epage>213</epage><pages>205-213</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>1 The sensitivity of long-term toxicity tests is impaired due to the 'background noise' of spontaneous lesions which are unrelated to treatment.
2 The need for a comprehensive source of computerized information concerning the occurrence and incidence of spontaneous lesions in control animals has been highlighted by initiatives in Europe and the USA. It is, however, essential to identify the potential users, and the type of information required for such a database to be of value.
3 This information has been acquired following an international survey of the pharmaceutical industry in Europe, Japan and the USA, including responses from 48 toxicologists and toxicopathologists representing 38 company groups.
4 Thirty-eight respondents indicated that they would use a historical control database that was regularly updated with the majority of respondents suggesting that they currently use external sources (Breeder's data, the literature, other companies) occasionally to acquire information on control animal pathology data.
5 The majority (94%) of the respondents indicated that a control animal database should contain information on both neoplastic and non-neoplastic lesions for use in evaluating long-term studies, in particular carcinogenicity studies.
6 The survey confirms the need for a historical control animal pathology database wider then those currently available.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>1678951</pmid><doi>10.1177/096032719101000310</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-3271 |
| ispartof | Human & experimental toxicology, 1991-05, Vol.10 (3), p.205-213 |
| issn | 0960-3271 1477-0903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21098056 |
| source | MEDLINE; SAGE Complete A-Z List; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Carcinogenicity Tests Databases, Factual Dogs Europe General aspects. Methods International Cooperation Japan Macaca fascicularis Medical sciences Mice Pathology Rats Rats, Inbred F344 Rats, Inbred Strains Surveys and Questionnaires Toxicology United States |
| title | The Need for a Control Animal Pathology Database: An International Survey |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T05%3A53%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Need%20for%20a%20Control%20Animal%20Pathology%20Database:%20An%20International%20Survey&rft.jtitle=Human%20&%20experimental%20toxicology&rft.au=McAuslane,%20J.A.N.&rft.date=1991-05-01&rft.volume=10&rft.issue=3&rft.spage=205&rft.epage=213&rft.pages=205-213&rft.issn=0960-3271&rft.eissn=1477-0903&rft_id=info:doi/10.1177/096032719101000310&rft_dat=%3Cproquest_cross%3E21098056%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21098056&rft_id=info:pmid/1678951&rft_sage_id=10.1177_096032719101000310&rfr_iscdi=true |