Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-κB pathways in rhinovirus-infected epithelial cells

Background Nitric oxide (NO) has previously been shown to inhibit human rhinovirus (HRV) replication in airway epithelial cells and to inhibit rhinovirus-induced epithelial cytokine and chemokine production independently of its effects on viral replication by modulating nuclear translocation and bin...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2009-09, Vol.124 (3), p.551-557
Hauptverfasser:	Koetzler, Rommy, MD, MSc, Zaheer, Raza S., BSc, Newton, Robert, PhD, Proud, David, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	airway epithelial cells Allergy and Immunology asthma Biological and medical sciences Chemokines Chronic obstructive pulmonary disease, asthma CXCL10 CXCL10 protein Cytokines Electrophoretic mobility Epithelial cells Fundamental and applied biological sciences. Psychology Fundamental immunology Human rhinovirus IFN regulatory factors Immunopathology Interferon Interferon regulatory factor 1 Medical sciences Molecular modelling NF-B protein Nitric oxide nuclear factor-κB Nuclear transport p50 protein Phosphorylation Pneumology Polymerase chain reaction Promoters Replication Respiratory tract Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Transcription factors Western blotting
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