Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat
The local tolerance of ketorolac tromethamine (Toradol®, Syntex) was compared with that of four other injectable nonsteroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium, piroxicam, ketoprofen, and metamizol magnesium) in the rat paw-lick/muscle irritation assay as described previously,1 All...
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| Veröffentlicht in: | Human & experimental toxicology 1994-02, Vol.13 (2), p.111-117 |
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| creator | Chellman, Gary J. Lollini, Lance O. Dorr, Albert E. DePass, Linval R. |
| description | The local tolerance of ketorolac tromethamine (Toradol®, Syntex) was compared with that of four other injectable nonsteroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium, piroxicam, ketoprofen, and metamizol magnesium) in the rat paw-lick/muscle irritation assay as described previously,1 All drugs were tested at concentrations approved for clinical use. After subplantar (footpad) injection, ketorolac produced virtually no pain-on-injection as assessed by the number of paw-lick/lift responses during a 15 min observation period. The other NSAIDs produced slight to moderate paw-lick/lift responses. Redness and swelling at the injection site were less severe for ketorolac than for the other NSAIDs, After intramuscular (i.m.) injection, all of the. NSAIDs produced some degree of muscle damage, as assessed histopathologically 24 h after injection. The lesions, consisting primarily of muscle degeneration, were less severe for ketorolac than for the other NSAIDs. Ketorolac and metamizol produced the smallest elevations in serum creatine kinase, as measured 2 h after i.m. dosing, not significantly different from isotonic saline. Overall, ketorolac was better tolerated in the assay than the other injectable NSAIDs, thereby suggesting the possibility of improved local tolerance on clinical use. |
| doi_str_mv | 10.1177/096032719401300209 |
| format | Article |
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After subplantar (footpad) injection, ketorolac produced virtually no pain-on-injection as assessed by the number of paw-lick/lift responses during a 15 min observation period. The other NSAIDs produced slight to moderate paw-lick/lift responses. Redness and swelling at the injection site were less severe for ketorolac than for the other NSAIDs, After intramuscular (i.m.) injection, all of the. NSAIDs produced some degree of muscle damage, as assessed histopathologically 24 h after injection. The lesions, consisting primarily of muscle degeneration, were less severe for ketorolac than for the other NSAIDs. Ketorolac and metamizol produced the smallest elevations in serum creatine kinase, as measured 2 h after i.m. dosing, not significantly different from isotonic saline. Overall, ketorolac was better tolerated in the assay than the other injectable NSAIDs, thereby suggesting the possibility of improved local tolerance on clinical use.</description><identifier>ISSN: 0960-3271</identifier><identifier>ISSN: 0144-5952</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719401300209</identifier><identifier>PMID: 7908807</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Analgesics ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - toxicity ; Biological and medical sciences ; Creatine Kinase - blood ; Drug Combinations ; Edema - chemically induced ; Hemorrhage - chemically induced ; Inflammation - chemically induced ; Injections, Intramuscular ; Ketorolac Tromethamine ; Leukocyte Count ; Male ; Medical sciences ; Muscles - drug effects ; Neuropharmacology ; Pain - chemically induced ; Pain Measurement ; Pharmacology. Drug treatments ; Rats ; Tolmetin - administration & dosage ; Tolmetin - analogs & derivatives ; Tolmetin - toxicity ; Tromethamine - administration & dosage ; Tromethamine - toxicity</subject><ispartof>Human & experimental toxicology, 1994-02, Vol.13 (2), p.111-117</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-8b20209cb6e36459806f27cf55511a10ec4232ee8610b6821291a24d0901464c3</citedby><cites>FETCH-LOGICAL-c344t-8b20209cb6e36459806f27cf55511a10ec4232ee8610b6821291a24d0901464c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719401300209$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719401300209$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3924275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7908807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chellman, Gary J.</creatorcontrib><creatorcontrib>Lollini, Lance O.</creatorcontrib><creatorcontrib>Dorr, Albert E.</creatorcontrib><creatorcontrib>DePass, Linval R.</creatorcontrib><title>Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>The local tolerance of ketorolac tromethamine (Toradol®, Syntex) was compared with that of four other injectable nonsteroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium, piroxicam, ketoprofen, and metamizol magnesium) in the rat paw-lick/muscle irritation assay as described previously,1 All drugs were tested at concentrations approved for clinical use. After subplantar (footpad) injection, ketorolac produced virtually no pain-on-injection as assessed by the number of paw-lick/lift responses during a 15 min observation period. The other NSAIDs produced slight to moderate paw-lick/lift responses. Redness and swelling at the injection site were less severe for ketorolac than for the other NSAIDs, After intramuscular (i.m.) injection, all of the. NSAIDs produced some degree of muscle damage, as assessed histopathologically 24 h after injection. The lesions, consisting primarily of muscle degeneration, were less severe for ketorolac than for the other NSAIDs. Ketorolac and metamizol produced the smallest elevations in serum creatine kinase, as measured 2 h after i.m. dosing, not significantly different from isotonic saline. Overall, ketorolac was better tolerated in the assay than the other injectable NSAIDs, thereby suggesting the possibility of improved local tolerance on clinical use.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - toxicity</subject><subject>Biological and medical sciences</subject><subject>Creatine Kinase - blood</subject><subject>Drug Combinations</subject><subject>Edema - chemically induced</subject><subject>Hemorrhage - chemically induced</subject><subject>Inflammation - chemically induced</subject><subject>Injections, Intramuscular</subject><subject>Ketorolac Tromethamine</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscles - drug effects</subject><subject>Neuropharmacology</subject><subject>Pain - chemically induced</subject><subject>Pain Measurement</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Tolmetin - administration & dosage</subject><subject>Tolmetin - analogs & derivatives</subject><subject>Tolmetin - toxicity</subject><subject>Tromethamine - administration & dosage</subject><subject>Tromethamine - toxicity</subject><issn>0960-3271</issn><issn>0144-5952</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAUhC0EKkvhDyAh-YC4hfo5jh0fq22BFYUiVM7Ri9fpepXYi-0I9W_wi3G0q16Q4OTD-2ZGniHkNbD3AEpdMC1ZzRVowaBmjDP9hKxAKFUxzeqnZLUA1UI8Jy9S2jPGpG7gjJwpzdqWqRX5vQ7TAaNLwdMw0M82hxhGNPQuhsnmHU7OW_rL5R29zTsb6cbvrcnYj5Z-DT5lG4Pb4kgvfXbVxg8jThMWkwd6Fef7RIcQ6Td0vgq-OmpdiUK_pV_mZIrLFU54b6nztPjT75hfkmcDjsm-Or3n5MeH67v1p-rm9uNmfXlTmVqIXLU9X35semlrKRrdMjlwZYamaQAQmDWC19zaVgLrZcuBa0AutqUaEFKY-py8O_oeYvg525S7ySVjxxG9DXPqOJT6mlb9FwTZQgu6KSA_giaGlKIdukN0E8aHDli3LNb9vVgRvTm5z_1kt4-S00Tl_vZ0x2RwHCJ649IjVmsuuFqyL45YKm12-zBHX8r7V_AfCmaqiQ</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>Chellman, Gary J.</creator><creator>Lollini, Lance O.</creator><creator>Dorr, Albert E.</creator><creator>DePass, Linval R.</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199402</creationdate><title>Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat</title><author>Chellman, Gary J. ; Lollini, Lance O. ; Dorr, Albert E. ; DePass, Linval R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-8b20209cb6e36459806f27cf55511a10ec4232ee8610b6821291a24d0901464c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Analgesics</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - toxicity</topic><topic>Biological and medical sciences</topic><topic>Creatine Kinase - blood</topic><topic>Drug Combinations</topic><topic>Edema - chemically induced</topic><topic>Hemorrhage - chemically induced</topic><topic>Inflammation - chemically induced</topic><topic>Injections, Intramuscular</topic><topic>Ketorolac Tromethamine</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscles - drug effects</topic><topic>Neuropharmacology</topic><topic>Pain - chemically induced</topic><topic>Pain Measurement</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Tolmetin - administration & dosage</topic><topic>Tolmetin - analogs & derivatives</topic><topic>Tolmetin - toxicity</topic><topic>Tromethamine - administration & dosage</topic><topic>Tromethamine - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chellman, Gary J.</creatorcontrib><creatorcontrib>Lollini, Lance O.</creatorcontrib><creatorcontrib>Dorr, Albert E.</creatorcontrib><creatorcontrib>DePass, Linval R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chellman, Gary J.</au><au>Lollini, Lance O.</au><au>Dorr, Albert E.</au><au>DePass, Linval R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1994-02</date><risdate>1994</risdate><volume>13</volume><issue>2</issue><spage>111</spage><epage>117</epage><pages>111-117</pages><issn>0960-3271</issn><issn>0144-5952</issn><eissn>1477-0903</eissn><abstract>The local tolerance of ketorolac tromethamine (Toradol®, Syntex) was compared with that of four other injectable nonsteroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium, piroxicam, ketoprofen, and metamizol magnesium) in the rat paw-lick/muscle irritation assay as described previously,1 All drugs were tested at concentrations approved for clinical use. After subplantar (footpad) injection, ketorolac produced virtually no pain-on-injection as assessed by the number of paw-lick/lift responses during a 15 min observation period. The other NSAIDs produced slight to moderate paw-lick/lift responses. Redness and swelling at the injection site were less severe for ketorolac than for the other NSAIDs, After intramuscular (i.m.) injection, all of the. NSAIDs produced some degree of muscle damage, as assessed histopathologically 24 h after injection. The lesions, consisting primarily of muscle degeneration, were less severe for ketorolac than for the other NSAIDs. Ketorolac and metamizol produced the smallest elevations in serum creatine kinase, as measured 2 h after i.m. dosing, not significantly different from isotonic saline. Overall, ketorolac was better tolerated in the assay than the other injectable NSAIDs, thereby suggesting the possibility of improved local tolerance on clinical use.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>7908807</pmid><doi>10.1177/096032719401300209</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Human & experimental toxicology, 1994-02, Vol.13 (2), p.111-117 |
| issn | 0960-3271 0144-5952 1477-0903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21096587 |
| source | SAGE Complete A-Z List; MEDLINE; Alma/SFX Local Collection |
| subjects | Analgesics Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - toxicity Biological and medical sciences Creatine Kinase - blood Drug Combinations Edema - chemically induced Hemorrhage - chemically induced Inflammation - chemically induced Injections, Intramuscular Ketorolac Tromethamine Leukocyte Count Male Medical sciences Muscles - drug effects Neuropharmacology Pain - chemically induced Pain Measurement Pharmacology. Drug treatments Rats Tolmetin - administration & dosage Tolmetin - analogs & derivatives Tolmetin - toxicity Tromethamine - administration & dosage Tromethamine - toxicity |
| title | Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat |
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