Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer

mutations are divided into functional classes distinguished by signaling mechanism and kinase activity: V600-mutant kinase-activating monomers (class I), kinase-activating dimers (class II), and kinase-inactivating heterodimers (class III). The relationship between functional class and disease chara...

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Veröffentlicht in:	Clinical cancer research 2019-01, Vol.25 (1), p.158-165
Hauptverfasser:	Dagogo-Jack, Ibiayi, Martinez, Pablo, Yeap, Beow Y, Ambrogio, Chiara, Ferris, Lorin A, Lydon, Christine, Nguyen, Tom, Jessop, Nicholas A, Iafrate, A John, Johnson, Bruce E, Lennerz, Jochen K, Shaw, Alice T, Awad, Mark M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung - classification Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Female Humans Male Middle Aged Mutation Prognosis Progression-Free Survival Proto-Oncogene Proteins B-raf - genetics Retrospective Studies
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