Platelet-rich plasma vs. steroid injections for hamstring injury—is there really a choice?
Objective To assess the effectiveness of pain relief in patients with grade 2 proximal hamstring injury, treated with platelet-rich plasma (PRP) or corticosteroid injection, by using the primary outcome of visual analog scale (VAS) at 1 week and 4 weeks of follow-up. Materials and methods A single i...
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| Veröffentlicht in: | Skeletal radiology 2019-04, Vol.48 (4), p.577-582 |
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| creator | Park, Peter Yong Soo Cai, Chunyan Bawa, Pritish Kumaravel, Manickam |
| description | Objective
To assess the effectiveness of pain relief in patients with grade 2 proximal hamstring injury, treated with platelet-rich plasma (PRP) or corticosteroid injection, by using the primary outcome of visual analog scale (VAS) at 1 week and 4 weeks of follow-up.
Materials and methods
A single institution retrospective study was performed for image-guided PRP or steroid injections between 12/1/2015 and 10/30/2017 for proximal hamstring injuries. VAS was measured at 1 week and 4 weeks post-injection via telephone interviews and the pain response was recorded into two groups (negative/no change vs. positive). A comparison of pain responses between PRP and steroid was conducted by generalized estimating equation.
Results
Among 56 patients, 32 received PRP and 24 received steroid injections with ages from 13 to 75 years old. At 1 week post-injection follow-up, 23 patients (71.9%) from the PRP group and 11 patients (45.8%) from the steroid group showed positive response. After controlling for age, pre-procedure pain level, and gender, the positive response rate in the PRP group was higher than the steroid group (aOR: 4.04, 95% CI: 1.04–15.63,
p
value = 0.04). At 4 weeks post-injection, 23 patients (71.9%) from the PRP group and 13 patients (54.2%) from the steroid group showed positive response with no statistical significance (aOR: 2.48, 95% CI: 0.63–9.79,
p
value = 0.19).
Conclusions
The PRP group had shown more favorable response compared to steroid group at 1 week post-injection, which suggests that PRP therapy can be considered as a conservative treatment choice for grade 2 proximal hamstring injuries with better short-term pain relief based on limited pilot data. |
| doi_str_mv | 10.1007/s00256-018-3063-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2109330009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A731337732</galeid><sourcerecordid>A731337732</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-960601ed4edf54691877ef9e2926cdeefed1cdd202c39fb5a3a1b4e717437d5f3</originalsourceid><addsrcrecordid>eNp1kcGKFDEURYMoTtv6AW4k4MZNtS9JVVK1kmFwVBjQhe6EkE5eptNUVdokNdA7P8IvnC-xih4dFCWQQHLu5YVDyHMGGwagXmcA3sgKWFsJkKLqHpAVqwWvOJPsIVmBkHXFRd2ekSc57wGYUo18TM4E8DkI7Yp8_dSbgj2WKgW7o4fe5MHQm7yhuWCKwdEw7tGWEMdMfUx0Z4ZcUhivl4cpHW-__wiZlh0mpAlN3x-poXYXg8U3T8kjb_qMz-7ONfly-fbzxfvq6uO7DxfnV5WtRVeqToIEhq5G55tadqxVCn2HvOPSOkSPjlnnOHArOr9tjDBsW6NiqhbKNV6syatT7yHFbxPmooeQLfa9GTFOWXMGnRAA874mL_9C93FK4zzdQrXA27ZV99S16VGH0ceSjF1K9bkSTAilBJ-pzT-oeTkcgo0j-jDf_xFgp4BNMeeEXh9SGEw6agZ6MapPRvVsVC9G9TLwi7uBp-2A7nfil8IZ4CcgHxYtmO5_9P_Wn3yqqr4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2108028887</pqid></control><display><type>article</type><title>Platelet-rich plasma vs. steroid injections for hamstring injury—is there really a choice?</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Park, Peter Yong Soo ; Cai, Chunyan ; Bawa, Pritish ; Kumaravel, Manickam</creator><creatorcontrib>Park, Peter Yong Soo ; Cai, Chunyan ; Bawa, Pritish ; Kumaravel, Manickam</creatorcontrib><description>Objective
To assess the effectiveness of pain relief in patients with grade 2 proximal hamstring injury, treated with platelet-rich plasma (PRP) or corticosteroid injection, by using the primary outcome of visual analog scale (VAS) at 1 week and 4 weeks of follow-up.
Materials and methods
A single institution retrospective study was performed for image-guided PRP or steroid injections between 12/1/2015 and 10/30/2017 for proximal hamstring injuries. VAS was measured at 1 week and 4 weeks post-injection via telephone interviews and the pain response was recorded into two groups (negative/no change vs. positive). A comparison of pain responses between PRP and steroid was conducted by generalized estimating equation.
Results
Among 56 patients, 32 received PRP and 24 received steroid injections with ages from 13 to 75 years old. At 1 week post-injection follow-up, 23 patients (71.9%) from the PRP group and 11 patients (45.8%) from the steroid group showed positive response. After controlling for age, pre-procedure pain level, and gender, the positive response rate in the PRP group was higher than the steroid group (aOR: 4.04, 95% CI: 1.04–15.63,
p
value = 0.04). At 4 weeks post-injection, 23 patients (71.9%) from the PRP group and 13 patients (54.2%) from the steroid group showed positive response with no statistical significance (aOR: 2.48, 95% CI: 0.63–9.79,
p
value = 0.19).
Conclusions
The PRP group had shown more favorable response compared to steroid group at 1 week post-injection, which suggests that PRP therapy can be considered as a conservative treatment choice for grade 2 proximal hamstring injuries with better short-term pain relief based on limited pilot data.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s00256-018-3063-9</identifier><identifier>PMID: 30225608</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Care and treatment ; Comparative analysis ; Corticosteroids ; Female ; Glucocorticoids - administration & dosage ; Hamstring Muscles - injuries ; Humans ; Imaging ; Injection ; Injections ; Injuries ; Injury prevention ; Interviews as Topic ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Nuclear Medicine ; Orthopedics ; Pain ; Pain Management - methods ; Pain Measurement ; Pathology ; Patients ; Platelet-Rich Plasma ; Platelets ; Radiology ; Retrospective Studies ; Scientific Article ; Soft Tissue Injuries - drug therapy ; Treatment Outcome</subject><ispartof>Skeletal radiology, 2019-04, Vol.48 (4), p.577-582</ispartof><rights>ISS 2018</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Skeletal Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-960601ed4edf54691877ef9e2926cdeefed1cdd202c39fb5a3a1b4e717437d5f3</citedby><cites>FETCH-LOGICAL-c439t-960601ed4edf54691877ef9e2926cdeefed1cdd202c39fb5a3a1b4e717437d5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00256-018-3063-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00256-018-3063-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30225608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Peter Yong Soo</creatorcontrib><creatorcontrib>Cai, Chunyan</creatorcontrib><creatorcontrib>Bawa, Pritish</creatorcontrib><creatorcontrib>Kumaravel, Manickam</creatorcontrib><title>Platelet-rich plasma vs. steroid injections for hamstring injury—is there really a choice?</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><addtitle>Skeletal Radiol</addtitle><description>Objective
To assess the effectiveness of pain relief in patients with grade 2 proximal hamstring injury, treated with platelet-rich plasma (PRP) or corticosteroid injection, by using the primary outcome of visual analog scale (VAS) at 1 week and 4 weeks of follow-up.
Materials and methods
A single institution retrospective study was performed for image-guided PRP or steroid injections between 12/1/2015 and 10/30/2017 for proximal hamstring injuries. VAS was measured at 1 week and 4 weeks post-injection via telephone interviews and the pain response was recorded into two groups (negative/no change vs. positive). A comparison of pain responses between PRP and steroid was conducted by generalized estimating equation.
Results
Among 56 patients, 32 received PRP and 24 received steroid injections with ages from 13 to 75 years old. At 1 week post-injection follow-up, 23 patients (71.9%) from the PRP group and 11 patients (45.8%) from the steroid group showed positive response. After controlling for age, pre-procedure pain level, and gender, the positive response rate in the PRP group was higher than the steroid group (aOR: 4.04, 95% CI: 1.04–15.63,
p
value = 0.04). At 4 weeks post-injection, 23 patients (71.9%) from the PRP group and 13 patients (54.2%) from the steroid group showed positive response with no statistical significance (aOR: 2.48, 95% CI: 0.63–9.79,
p
value = 0.19).
Conclusions
The PRP group had shown more favorable response compared to steroid group at 1 week post-injection, which suggests that PRP therapy can be considered as a conservative treatment choice for grade 2 proximal hamstring injuries with better short-term pain relief based on limited pilot data.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Corticosteroids</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Hamstring Muscles - injuries</subject><subject>Humans</subject><subject>Imaging</subject><subject>Injection</subject><subject>Injections</subject><subject>Injuries</subject><subject>Injury prevention</subject><subject>Interviews as Topic</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Nuclear Medicine</subject><subject>Orthopedics</subject><subject>Pain</subject><subject>Pain Management - methods</subject><subject>Pain Measurement</subject><subject>Pathology</subject><subject>Patients</subject><subject>Platelet-Rich Plasma</subject><subject>Platelets</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Scientific Article</subject><subject>Soft Tissue Injuries - drug therapy</subject><subject>Treatment Outcome</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kcGKFDEURYMoTtv6AW4k4MZNtS9JVVK1kmFwVBjQhe6EkE5eptNUVdokNdA7P8IvnC-xih4dFCWQQHLu5YVDyHMGGwagXmcA3sgKWFsJkKLqHpAVqwWvOJPsIVmBkHXFRd2ekSc57wGYUo18TM4E8DkI7Yp8_dSbgj2WKgW7o4fe5MHQm7yhuWCKwdEw7tGWEMdMfUx0Z4ZcUhivl4cpHW-__wiZlh0mpAlN3x-poXYXg8U3T8kjb_qMz-7ONfly-fbzxfvq6uO7DxfnV5WtRVeqToIEhq5G55tadqxVCn2HvOPSOkSPjlnnOHArOr9tjDBsW6NiqhbKNV6syatT7yHFbxPmooeQLfa9GTFOWXMGnRAA874mL_9C93FK4zzdQrXA27ZV99S16VGH0ceSjF1K9bkSTAilBJ-pzT-oeTkcgo0j-jDf_xFgp4BNMeeEXh9SGEw6agZ6MapPRvVsVC9G9TLwi7uBp-2A7nfil8IZ4CcgHxYtmO5_9P_Wn3yqqr4</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Park, Peter Yong Soo</creator><creator>Cai, Chunyan</creator><creator>Bawa, Pritish</creator><creator>Kumaravel, Manickam</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Platelet-rich plasma vs. steroid injections for hamstring injury—is there really a choice?</title><author>Park, Peter Yong Soo ; Cai, Chunyan ; Bawa, Pritish ; Kumaravel, Manickam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-960601ed4edf54691877ef9e2926cdeefed1cdd202c39fb5a3a1b4e717437d5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Corticosteroids</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Hamstring Muscles - injuries</topic><topic>Humans</topic><topic>Imaging</topic><topic>Injection</topic><topic>Injections</topic><topic>Injuries</topic><topic>Injury prevention</topic><topic>Interviews as Topic</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Nuclear Medicine</topic><topic>Orthopedics</topic><topic>Pain</topic><topic>Pain Management - methods</topic><topic>Pain Measurement</topic><topic>Pathology</topic><topic>Patients</topic><topic>Platelet-Rich Plasma</topic><topic>Platelets</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Scientific Article</topic><topic>Soft Tissue Injuries - drug therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Peter Yong Soo</creatorcontrib><creatorcontrib>Cai, Chunyan</creatorcontrib><creatorcontrib>Bawa, Pritish</creatorcontrib><creatorcontrib>Kumaravel, Manickam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Skeletal radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Peter Yong Soo</au><au>Cai, Chunyan</au><au>Bawa, Pritish</au><au>Kumaravel, Manickam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet-rich plasma vs. steroid injections for hamstring injury—is there really a choice?</atitle><jtitle>Skeletal radiology</jtitle><stitle>Skeletal Radiol</stitle><addtitle>Skeletal Radiol</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>48</volume><issue>4</issue><spage>577</spage><epage>582</epage><pages>577-582</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><abstract>Objective
To assess the effectiveness of pain relief in patients with grade 2 proximal hamstring injury, treated with platelet-rich plasma (PRP) or corticosteroid injection, by using the primary outcome of visual analog scale (VAS) at 1 week and 4 weeks of follow-up.
Materials and methods
A single institution retrospective study was performed for image-guided PRP or steroid injections between 12/1/2015 and 10/30/2017 for proximal hamstring injuries. VAS was measured at 1 week and 4 weeks post-injection via telephone interviews and the pain response was recorded into two groups (negative/no change vs. positive). A comparison of pain responses between PRP and steroid was conducted by generalized estimating equation.
Results
Among 56 patients, 32 received PRP and 24 received steroid injections with ages from 13 to 75 years old. At 1 week post-injection follow-up, 23 patients (71.9%) from the PRP group and 11 patients (45.8%) from the steroid group showed positive response. After controlling for age, pre-procedure pain level, and gender, the positive response rate in the PRP group was higher than the steroid group (aOR: 4.04, 95% CI: 1.04–15.63,
p
value = 0.04). At 4 weeks post-injection, 23 patients (71.9%) from the PRP group and 13 patients (54.2%) from the steroid group showed positive response with no statistical significance (aOR: 2.48, 95% CI: 0.63–9.79,
p
value = 0.19).
Conclusions
The PRP group had shown more favorable response compared to steroid group at 1 week post-injection, which suggests that PRP therapy can be considered as a conservative treatment choice for grade 2 proximal hamstring injuries with better short-term pain relief based on limited pilot data.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30225608</pmid><doi>10.1007/s00256-018-3063-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Skeletal radiology, 2019-04, Vol.48 (4), p.577-582 |
| issn | 0364-2348 1432-2161 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adolescent Adult Aged Care and treatment Comparative analysis Corticosteroids Female Glucocorticoids - administration & dosage Hamstring Muscles - injuries Humans Imaging Injection Injections Injuries Injury prevention Interviews as Topic Male Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Nuclear Medicine Orthopedics Pain Pain Management - methods Pain Measurement Pathology Patients Platelet-Rich Plasma Platelets Radiology Retrospective Studies Scientific Article Soft Tissue Injuries - drug therapy Treatment Outcome |
| title | Platelet-rich plasma vs. steroid injections for hamstring injury—is there really a choice? |
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