Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction

Interstitial fibrosis after acute myocardial infarction (MI) leads to cardiac structural remodeling and dysfunction. The peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist chrysin has been shown to protect injured myocardium through suppression of oxidative stress and inflammation. Th...

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Veröffentlicht in:	Journal of molecular histology 2018-12, Vol.49 (6), p.555-565
Hauptverfasser:	Yang, Mei, Xiong, Jun, Zou, Qiang, Wang, Dan-Dan, Huang, Cong-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Biomedical and Life Sciences Biomedicine Carboxymethylcellulose Cardiac function Cell Biology Collagen (type III) Coronary artery Developmental Biology Disease Models, Animal Echocardiography Enzyme inhibitors Fibroblasts Fibroblasts - drug effects Fibrosis Fibrosis - drug therapy Flavonoids - pharmacology Flavonoids - therapeutic use Gelatinase A Gelatinase B Heart - physiopathology Heart attacks Immunohistochemistry Life Sciences Matrix metalloproteinase Metalloproteinase Myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardium NF-kappa B - antagonists & inhibitors NF-κB protein Original Paper Oxidative stress Peroxisome proliferator-activated receptors Phosphorylation PPAR gamma - agonists PPAR gamma - genetics Rats Rodents Sodium Transcription Factor AP-1 - antagonists & inhibitors Transcription Factor AP-1 - metabolism Transcription factors Up-Regulation - drug effects
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