Thirty‐day hospital readmission rate amongst older adults correlates with an increased number of medications, but not with Beers medications

Aim We sought to explore the relationship between the number of medications at hospital discharge and 30‐day rehospitalization in older adults aged >65 years. Methods This was a multicenter cohort study to determine whether an increased number of medications was associated with 30‐day rehospitali...

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Veröffentlicht in:Geriatrics & gerontology international 2018-10, Vol.18 (10), p.1513-1518
Hauptverfasser: Basnet, Suresh, Zhang, Meng, Lesser, Martin, Wolf‐Klein, Gisele, Qiu, Guang, Williams, Myia, Pekmezaris, Renee, DiMarzio, Paola
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container_end_page 1518
container_issue 10
container_start_page 1513
container_title Geriatrics & gerontology international
container_volume 18
creator Basnet, Suresh
Zhang, Meng
Lesser, Martin
Wolf‐Klein, Gisele
Qiu, Guang
Williams, Myia
Pekmezaris, Renee
DiMarzio, Paola
description Aim We sought to explore the relationship between the number of medications at hospital discharge and 30‐day rehospitalization in older adults aged >65 years. Methods This was a multicenter cohort study to determine whether an increased number of medications was associated with 30‐day rehospitalization in patients aged >65 years. We explored the relationship between rehospitalization and other risk factors. Data were collected from a large health system in the New York metropolitan area from September 2011 to January 2013. The primary outcome was 30‐day hospital readmission from the index hospitalization. Results Patients had a mean ± SD age of 78 ± 9 years; 55% were women. The average length of stay after discharge from the hospital was 6 days. An increased number of medications was significantly associated with unplanned 30‐day hospital readmission (P 
doi_str_mv 10.1111/ggi.13518
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Methods This was a multicenter cohort study to determine whether an increased number of medications was associated with 30‐day rehospitalization in patients aged &gt;65 years. We explored the relationship between rehospitalization and other risk factors. Data were collected from a large health system in the New York metropolitan area from September 2011 to January 2013. The primary outcome was 30‐day hospital readmission from the index hospitalization. Results Patients had a mean ± SD age of 78 ± 9 years; 55% were women. The average length of stay after discharge from the hospital was 6 days. An increased number of medications was significantly associated with unplanned 30‐day hospital readmission (P &lt; 0.05). For each medication, the risk of rehospitalization increased by 4% (OR 1.04, 95% CI 1.03, 1.05). Patients discharged to rehabilitation centers were 32% more likely to be readmitted than patients discharged home (OR 1.39, 95% CI 1.27–1.51). Other risk factors significantly associated with 30‐day rehospitalization were: cancer, intensive care unit, chronic heart failure, renal diseases and peripheral vascular diseases. Hypertension was negatively associated with 30‐day unplanned rehospitalization (OR 0.88, 95% CI 0.82–0.95). No significant association between the number of Beers medications and 30‐day rehospitalization was observed, after controlling for the number of medications and other covariates. Conclusions The number of discharge medications was significantly associated with 30‐day hospital readmission among older adult patients. Important risk factors for 30‐day rehospitalization were discharge location, cancer, intensive care unit, chronic heart failure, renal diseases and peripheral vascular diseases. Geriatr Gerontol Int 2018; 18: 1513–1518.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.13518</identifier><identifier>PMID: 30225904</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley &amp; Sons Australia, Ltd</publisher><subject>Aged ; Aged, 80 and over ; Cohort Studies ; Drug Utilization ; Female ; Geriatric Assessment ; Heart failure ; hospital readmission ; Hospitalization - statistics &amp; numerical data ; Humans ; Incidence ; Intensive care ; Kidney diseases ; Length of Stay ; Logistic Models ; Male ; medical history ; medications ; Mortality - trends ; Multivariate Analysis ; New York ; older adults ; Older people ; Patient admissions ; Patient Discharge ; Patient Readmission - statistics &amp; numerical data ; Polypharmacy ; Potentially Inappropriate Medication List ; Retrospective Studies ; Risk Assessment ; Risk factors ; Time Factors</subject><ispartof>Geriatrics &amp; gerontology international, 2018-10, Vol.18 (10), p.1513-1518</ispartof><rights>2018 Japan Geriatrics Society</rights><rights>2018 Japan Geriatrics Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3778-c7fd626aea9a515ef1020a35aea9bb01ff1dccc43cc874f39bac4e5655ecd61a3</citedby><cites>FETCH-LOGICAL-c3778-c7fd626aea9a515ef1020a35aea9bb01ff1dccc43cc874f39bac4e5655ecd61a3</cites><orcidid>0000-0002-6295-8391 ; 0000-0003-1860-8754</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fggi.13518$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fggi.13518$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30225904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Basnet, Suresh</creatorcontrib><creatorcontrib>Zhang, Meng</creatorcontrib><creatorcontrib>Lesser, Martin</creatorcontrib><creatorcontrib>Wolf‐Klein, Gisele</creatorcontrib><creatorcontrib>Qiu, Guang</creatorcontrib><creatorcontrib>Williams, Myia</creatorcontrib><creatorcontrib>Pekmezaris, Renee</creatorcontrib><creatorcontrib>DiMarzio, Paola</creatorcontrib><title>Thirty‐day hospital readmission rate amongst older adults correlates with an increased number of medications, but not with Beers medications</title><title>Geriatrics &amp; gerontology international</title><addtitle>Geriatr Gerontol Int</addtitle><description>Aim We sought to explore the relationship between the number of medications at hospital discharge and 30‐day rehospitalization in older adults aged &gt;65 years. Methods This was a multicenter cohort study to determine whether an increased number of medications was associated with 30‐day rehospitalization in patients aged &gt;65 years. We explored the relationship between rehospitalization and other risk factors. Data were collected from a large health system in the New York metropolitan area from September 2011 to January 2013. The primary outcome was 30‐day hospital readmission from the index hospitalization. Results Patients had a mean ± SD age of 78 ± 9 years; 55% were women. The average length of stay after discharge from the hospital was 6 days. An increased number of medications was significantly associated with unplanned 30‐day hospital readmission (P &lt; 0.05). For each medication, the risk of rehospitalization increased by 4% (OR 1.04, 95% CI 1.03, 1.05). Patients discharged to rehabilitation centers were 32% more likely to be readmitted than patients discharged home (OR 1.39, 95% CI 1.27–1.51). Other risk factors significantly associated with 30‐day rehospitalization were: cancer, intensive care unit, chronic heart failure, renal diseases and peripheral vascular diseases. Hypertension was negatively associated with 30‐day unplanned rehospitalization (OR 0.88, 95% CI 0.82–0.95). No significant association between the number of Beers medications and 30‐day rehospitalization was observed, after controlling for the number of medications and other covariates. Conclusions The number of discharge medications was significantly associated with 30‐day hospital readmission among older adult patients. Important risk factors for 30‐day rehospitalization were discharge location, cancer, intensive care unit, chronic heart failure, renal diseases and peripheral vascular diseases. Geriatr Gerontol Int 2018; 18: 1513–1518.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cohort Studies</subject><subject>Drug Utilization</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Heart failure</subject><subject>hospital readmission</subject><subject>Hospitalization - statistics &amp; numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive care</subject><subject>Kidney diseases</subject><subject>Length of Stay</subject><subject>Logistic Models</subject><subject>Male</subject><subject>medical history</subject><subject>medications</subject><subject>Mortality - trends</subject><subject>Multivariate Analysis</subject><subject>New York</subject><subject>older adults</subject><subject>Older people</subject><subject>Patient admissions</subject><subject>Patient Discharge</subject><subject>Patient Readmission - statistics &amp; numerical data</subject><subject>Polypharmacy</subject><subject>Potentially Inappropriate Medication List</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>Time Factors</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctO3TAQhq2KqlwXvACyxKZIBDxJnMsSUDlFQuoG1tHEnpxjlMQH2xE6O56g6jP2SWoIVBVSvbHl-ebTjH7GDkGcQTzny6U5g0xC9YntQJ6XiZB1vvX6zhOQVbHNdr1_EALKGuAL285Emspa5Dvs593KuLD5_fxL44avrF-bgD13hHow3hs7coeBOA52XPrAba_JcdRTHzxX1jnqY9nzJxNWHEduRhV7PWk-TkMbUdvxgbRRGKLLn_J2Cny0YW64JHL-3_o--9xh7-ng7d5j99ff7q6-J7c_FjdXF7eJysqySlTZ6SItkLBGCZI6EKnATL58tK2ArgOtlMozpaoy77K6RZWTLKQkpQvAbI99nb1rZx8n8qGJ2yrqexzJTr5JQdRZWlUgInr8AX2wkxvjdJGCStRlCjJSJzOlnPXeUdesnRnQbRoQzUtITQypeQ0pskdvxqmNu_8l31OJwPkMPJmeNv83NYvFzaz8Aw9tn6M</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Basnet, Suresh</creator><creator>Zhang, Meng</creator><creator>Lesser, Martin</creator><creator>Wolf‐Klein, Gisele</creator><creator>Qiu, Guang</creator><creator>Williams, Myia</creator><creator>Pekmezaris, Renee</creator><creator>DiMarzio, Paola</creator><general>John Wiley &amp; Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6295-8391</orcidid><orcidid>https://orcid.org/0000-0003-1860-8754</orcidid></search><sort><creationdate>201810</creationdate><title>Thirty‐day hospital readmission rate amongst older adults correlates with an increased number of medications, but not with Beers medications</title><author>Basnet, Suresh ; Zhang, Meng ; Lesser, Martin ; Wolf‐Klein, Gisele ; Qiu, Guang ; Williams, Myia ; Pekmezaris, Renee ; DiMarzio, Paola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3778-c7fd626aea9a515ef1020a35aea9bb01ff1dccc43cc874f39bac4e5655ecd61a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cohort Studies</topic><topic>Drug Utilization</topic><topic>Female</topic><topic>Geriatric Assessment</topic><topic>Heart failure</topic><topic>hospital readmission</topic><topic>Hospitalization - statistics &amp; numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive care</topic><topic>Kidney diseases</topic><topic>Length of Stay</topic><topic>Logistic Models</topic><topic>Male</topic><topic>medical history</topic><topic>medications</topic><topic>Mortality - trends</topic><topic>Multivariate Analysis</topic><topic>New York</topic><topic>older adults</topic><topic>Older people</topic><topic>Patient admissions</topic><topic>Patient Discharge</topic><topic>Patient Readmission - statistics &amp; numerical data</topic><topic>Polypharmacy</topic><topic>Potentially Inappropriate Medication List</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basnet, Suresh</creatorcontrib><creatorcontrib>Zhang, Meng</creatorcontrib><creatorcontrib>Lesser, Martin</creatorcontrib><creatorcontrib>Wolf‐Klein, Gisele</creatorcontrib><creatorcontrib>Qiu, Guang</creatorcontrib><creatorcontrib>Williams, Myia</creatorcontrib><creatorcontrib>Pekmezaris, Renee</creatorcontrib><creatorcontrib>DiMarzio, Paola</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics &amp; gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basnet, Suresh</au><au>Zhang, Meng</au><au>Lesser, Martin</au><au>Wolf‐Klein, Gisele</au><au>Qiu, Guang</au><au>Williams, Myia</au><au>Pekmezaris, Renee</au><au>DiMarzio, Paola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thirty‐day hospital readmission rate amongst older adults correlates with an increased number of medications, but not with Beers medications</atitle><jtitle>Geriatrics &amp; gerontology international</jtitle><addtitle>Geriatr Gerontol Int</addtitle><date>2018-10</date><risdate>2018</risdate><volume>18</volume><issue>10</issue><spage>1513</spage><epage>1518</epage><pages>1513-1518</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aim We sought to explore the relationship between the number of medications at hospital discharge and 30‐day rehospitalization in older adults aged &gt;65 years. Methods This was a multicenter cohort study to determine whether an increased number of medications was associated with 30‐day rehospitalization in patients aged &gt;65 years. We explored the relationship between rehospitalization and other risk factors. Data were collected from a large health system in the New York metropolitan area from September 2011 to January 2013. The primary outcome was 30‐day hospital readmission from the index hospitalization. Results Patients had a mean ± SD age of 78 ± 9 years; 55% were women. The average length of stay after discharge from the hospital was 6 days. An increased number of medications was significantly associated with unplanned 30‐day hospital readmission (P &lt; 0.05). For each medication, the risk of rehospitalization increased by 4% (OR 1.04, 95% CI 1.03, 1.05). Patients discharged to rehabilitation centers were 32% more likely to be readmitted than patients discharged home (OR 1.39, 95% CI 1.27–1.51). Other risk factors significantly associated with 30‐day rehospitalization were: cancer, intensive care unit, chronic heart failure, renal diseases and peripheral vascular diseases. Hypertension was negatively associated with 30‐day unplanned rehospitalization (OR 0.88, 95% CI 0.82–0.95). No significant association between the number of Beers medications and 30‐day rehospitalization was observed, after controlling for the number of medications and other covariates. Conclusions The number of discharge medications was significantly associated with 30‐day hospital readmission among older adult patients. Important risk factors for 30‐day rehospitalization were discharge location, cancer, intensive care unit, chronic heart failure, renal diseases and peripheral vascular diseases. Geriatr Gerontol Int 2018; 18: 1513–1518.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley &amp; Sons Australia, Ltd</pub><pmid>30225904</pmid><doi>10.1111/ggi.13518</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6295-8391</orcidid><orcidid>https://orcid.org/0000-0003-1860-8754</orcidid></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Aged
Aged, 80 and over
Cohort Studies
Drug Utilization
Female
Geriatric Assessment
Heart failure
hospital readmission
Hospitalization - statistics & numerical data
Humans
Incidence
Intensive care
Kidney diseases
Length of Stay
Logistic Models
Male
medical history
medications
Mortality - trends
Multivariate Analysis
New York
older adults
Older people
Patient admissions
Patient Discharge
Patient Readmission - statistics & numerical data
Polypharmacy
Potentially Inappropriate Medication List
Retrospective Studies
Risk Assessment
Risk factors
Time Factors
title Thirty‐day hospital readmission rate amongst older adults correlates with an increased number of medications, but not with Beers medications
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