Effect on Blood and Plasma Cyanide Levels and on Methaemoglobin Levels of Cyanide Administered with and without Previous Protection using PAPP
Hydrogen cyanide was administered intravenously at doses of 0.67 or 1.34 mg kg-1 to beagle pitches after protection with oral p-aminopropiophenone (0.5 mg kg-1). Hydrogen cyanide was also administered to unprotected bitches at the lower level (0.67 mg kg-1) only. PAPP protection caused sequestration...
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| Veröffentlicht in: | Human & experimental toxicology 1987-03, Vol.6 (2), p.139-145 |
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| container_title | Human & experimental toxicology |
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| creator | Marrs, T.C. Bright, J.E. |
| description | Hydrogen cyanide was administered intravenously at doses of 0.67 or 1.34 mg kg-1 to beagle pitches after protection with oral p-aminopropiophenone (0.5 mg kg-1). Hydrogen cyanide was also administered to unprotected bitches at the lower level (0.67 mg kg-1) only. PAPP protection caused sequestration of cyanide inside the red cells. In the case of the lower dose of cyanide this resulted in a lower plasma cyanide in protected than unprotected bitches. In the case of the higher dose it resulted in survival, despite 1.34 mg kg -1 being a known lethal dose. It is concluded that prior administration of PAPP ameliorated the effects of cyanide poisoning. |
| doi_str_mv | 10.1177/096032718700600206 |
| format | Article |
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Hydrogen cyanide was also administered to unprotected bitches at the lower level (0.67 mg kg-1) only. PAPP protection caused sequestration of cyanide inside the red cells. In the case of the lower dose of cyanide this resulted in a lower plasma cyanide in protected than unprotected bitches. In the case of the higher dose it resulted in survival, despite 1.34 mg kg -1 being a known lethal dose. It is concluded that prior administration of PAPP ameliorated the effects of cyanide poisoning.</description><identifier>ISSN: 0144-5952</identifier><identifier>ISSN: 0960-3271</identifier><identifier>DOI: 10.1177/096032718700600206</identifier><identifier>PMID: 3557471</identifier><identifier>CODEN: HUTODJ</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. 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Toxic occupational diseases</subject><subject>Cyanides - antagonists & inhibitors</subject><subject>Cyanides - blood</subject><subject>Cyanides - pharmacology</subject><subject>Dogs</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Methemoglobin - metabolism</subject><subject>Propiophenones - pharmacology</subject><subject>Toxicology</subject><issn>0144-5952</issn><issn>0960-3271</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhb0AlVL6AkhIXiB2Q69_4jjLYVR-pEHNgq4jx76ZukrsYidFfQmeGbczzAaJrnyl851zrXsIecvgI2N1fQGNAsFrpmsABcBBvSCnwKRcVU3FX5HXOd8CiILKE3IiqqqWNTslvy-HAe1MY6CfxhgdNcHRdjR5MnTzYIJ3SLd4j2N-Ugr2Hecbg1PcjbH34a8YhyO-dpMPPs-Y0NFffr55cj4OcZlpm_DexyWXIc5lsy-RS_ZhR9t1274hLwczZjw_vGfk-vPlj83X1fbqy7fNeruyotbzSoPV1jrhOIcBK8F0L5xutMNyC-aUlsIyRN0MwjRaCcm07C24hnHV95KJM_Jhn3uX4s8F89xNPlscRxOwfK7jDBoBTfUsyKSqJJe6gHwP2hRzTjh0d8lPJj10DLrHhrp_Gyqmd4f0pZ_QHS2Heor-_qCbbM04JBOsz0dMc6mUEAW72GPZ7LC7jUsK5Xj_W_wH2Kin6Q</recordid><startdate>198703</startdate><enddate>198703</enddate><creator>Marrs, T.C.</creator><creator>Bright, J.E.</creator><general>SAGE Publications</general><general>Macmillan</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198703</creationdate><title>Effect on Blood and Plasma Cyanide Levels and on Methaemoglobin Levels of Cyanide Administered with and without Previous Protection using PAPP</title><author>Marrs, T.C. ; Bright, J.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-80c8ccd3d220fe5318b3d898de1171d6843c1ee89f3a98634184bc0d9126bb413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cyanides - antagonists & inhibitors</topic><topic>Cyanides - blood</topic><topic>Cyanides - pharmacology</topic><topic>Dogs</topic><topic>Erythrocytes - metabolism</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Methemoglobin - metabolism</topic><topic>Propiophenones - pharmacology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marrs, T.C.</creatorcontrib><creatorcontrib>Bright, J.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marrs, T.C.</au><au>Bright, J.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect on Blood and Plasma Cyanide Levels and on Methaemoglobin Levels of Cyanide Administered with and without Previous Protection using PAPP</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Toxicol</addtitle><date>1987-03</date><risdate>1987</risdate><volume>6</volume><issue>2</issue><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>0144-5952</issn><issn>0960-3271</issn><coden>HUTODJ</coden><abstract>Hydrogen cyanide was administered intravenously at doses of 0.67 or 1.34 mg kg-1 to beagle pitches after protection with oral p-aminopropiophenone (0.5 mg kg-1). Hydrogen cyanide was also administered to unprotected bitches at the lower level (0.67 mg kg-1) only. PAPP protection caused sequestration of cyanide inside the red cells. In the case of the lower dose of cyanide this resulted in a lower plasma cyanide in protected than unprotected bitches. In the case of the higher dose it resulted in survival, despite 1.34 mg kg -1 being a known lethal dose. It is concluded that prior administration of PAPP ameliorated the effects of cyanide poisoning.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>3557471</pmid><doi>10.1177/096032718700600206</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0144-5952 |
| ispartof | Human & experimental toxicology, 1987-03, Vol.6 (2), p.139-145 |
| issn | 0144-5952 0960-3271 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21093095 |
| source | MEDLINE; SAGE Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cyanides - antagonists & inhibitors Cyanides - blood Cyanides - pharmacology Dogs Erythrocytes - metabolism Female Medical sciences Metals and various inorganic compounds Methemoglobin - metabolism Propiophenones - pharmacology Toxicology |
| title | Effect on Blood and Plasma Cyanide Levels and on Methaemoglobin Levels of Cyanide Administered with and without Previous Protection using PAPP |
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