Decorporation of thorium-228 from the rat by 3,4,3-LIHOPO and DTPA after simulated wound contamination
1 With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treat ment was delayed 30 min, 6 h or 1 d and the an...
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| Veröffentlicht in: | Human & experimental toxicology 1995-02, Vol.14 (2), p.165-169 |
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| creator | Stradling, G.N. Gray, S.A. Pearce, M.J. Wilson, I. Moody, J.C. Burgada, R. Durbin, P.W. Raymond, K.N. |
| description | 1 With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treat ment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d.
2 In all cases 3,4,3-LIHOPO was appreciably more effec tive than DTPA although the efficacy of treatment and the relative effectiveness of the ligands decreased rapidly with their delay in administration.
3 Optimum removal with both ligands occurred when initial local administration at 30 min after exposure was followed by repeated intraperitoneal injection at 6 h, 1, 2 and 3 d. Under these conditions the body con tent of 228Th was reduced to 20% of controls after sc injection and 15% after im injection. The correspond ing values using repeated DTPA administration were 80% and 54%.
4 It is concluded that 3,4,3-LIHOPO represents, poten tially, a considerable advance on DTPA, the current agent of choice for the treatment of wounds contami nated by 228Th. |
| doi_str_mv | 10.1177/096032719501400202 |
| format | Article |
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2 In all cases 3,4,3-LIHOPO was appreciably more effec tive than DTPA although the efficacy of treatment and the relative effectiveness of the ligands decreased rapidly with their delay in administration.
3 Optimum removal with both ligands occurred when initial local administration at 30 min after exposure was followed by repeated intraperitoneal injection at 6 h, 1, 2 and 3 d. Under these conditions the body con tent of 228Th was reduced to 20% of controls after sc injection and 15% after im injection. The correspond ing values using repeated DTPA administration were 80% and 54%.
4 It is concluded that 3,4,3-LIHOPO represents, poten tially, a considerable advance on DTPA, the current agent of choice for the treatment of wounds contami nated by 228Th.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719501400202</identifier><identifier>PMID: 7779440</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Animals ; Aza Compounds - administration & dosage ; Aza Compounds - pharmacology ; Biological and medical sciences ; Biological effects of radiation ; Disease Models, Animal ; Female ; Fundamental and applied biological sciences. Psychology ; Injections, Intramuscular ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Kinetics ; Ligands ; Pentetic Acid - administration & dosage ; Pentetic Acid - pharmacology ; Pyridones - administration & dosage ; Pyridones - pharmacology ; Radiocontamination ; Rats ; Thorium Compounds - administration & dosage ; Thorium Compounds - metabolism ; Thorium Compounds - toxicity ; Tissues, organs and organisms biophysics ; Wound Healing - drug effects</subject><ispartof>Human & experimental toxicology, 1995-02, Vol.14 (2), p.165-169</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-11437d17e5ee6d0d5956db4e5582cbcefbe56654404d9e1e46ca76e0576e2b993</citedby><cites>FETCH-LOGICAL-c313t-11437d17e5ee6d0d5956db4e5582cbcefbe56654404d9e1e46ca76e0576e2b993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719501400202$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719501400202$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21817,27922,27923,43619,43620</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3445974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7779440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stradling, G.N.</creatorcontrib><creatorcontrib>Gray, S.A.</creatorcontrib><creatorcontrib>Pearce, M.J.</creatorcontrib><creatorcontrib>Wilson, I.</creatorcontrib><creatorcontrib>Moody, J.C.</creatorcontrib><creatorcontrib>Burgada, R.</creatorcontrib><creatorcontrib>Durbin, P.W.</creatorcontrib><creatorcontrib>Raymond, K.N.</creatorcontrib><title>Decorporation of thorium-228 from the rat by 3,4,3-LIHOPO and DTPA after simulated wound contamination</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>1 With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treat ment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d.
2 In all cases 3,4,3-LIHOPO was appreciably more effec tive than DTPA although the efficacy of treatment and the relative effectiveness of the ligands decreased rapidly with their delay in administration.
3 Optimum removal with both ligands occurred when initial local administration at 30 min after exposure was followed by repeated intraperitoneal injection at 6 h, 1, 2 and 3 d. Under these conditions the body con tent of 228Th was reduced to 20% of controls after sc injection and 15% after im injection. The correspond ing values using repeated DTPA administration were 80% and 54%.
4 It is concluded that 3,4,3-LIHOPO represents, poten tially, a considerable advance on DTPA, the current agent of choice for the treatment of wounds contami nated by 228Th.</description><subject>Animals</subject><subject>Aza Compounds - administration & dosage</subject><subject>Aza Compounds - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intramuscular</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Subcutaneous</subject><subject>Kinetics</subject><subject>Ligands</subject><subject>Pentetic Acid - administration & dosage</subject><subject>Pentetic Acid - pharmacology</subject><subject>Pyridones - administration & dosage</subject><subject>Pyridones - pharmacology</subject><subject>Radiocontamination</subject><subject>Rats</subject><subject>Thorium Compounds - administration & dosage</subject><subject>Thorium Compounds - metabolism</subject><subject>Thorium Compounds - toxicity</subject><subject>Tissues, organs and organisms biophysics</subject><subject>Wound Healing - drug effects</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoOqd_QBByIV6tLp-NuZT5NRhsF_O6pOmpVtpmJi3ivzd1xRvBmwTyPuc94UHogpIbSpWaE50SzhTVklBBCCPsAE2oUCohmvBDNBmAZCBO0GkI74SQVEt6jI6VUloIMkHlPVjnd86brnItdiXu3pyv-iZh7BaX3jXxAXCMcf6F-UzMeLJaPq83a2zaAt9vN3fYlB14HKqmr00HBf50fYysazvTVO1P8Rk6Kk0d4Hy8p-jl8WG7eE5W66fl4m6VWE55l1AquCqoAgmQFqSQWqZFLkDKW2ZzC2UOMk1l_LkoNFAQqTUqBSLjwXKt-RRd73t33n30ELqsqYKFujYtuD5kjA5mKI8g24PWuxA8lNnOV43xXxkl2SA3-ys3Dl2O7X3eQPE7MtqM-dWYm2BNXXrT2ir8YlwIqZWI2HyPBfMK2bvrfRud_Lf4GyvHjFI</recordid><startdate>199502</startdate><enddate>199502</enddate><creator>Stradling, G.N.</creator><creator>Gray, S.A.</creator><creator>Pearce, M.J.</creator><creator>Wilson, I.</creator><creator>Moody, J.C.</creator><creator>Burgada, R.</creator><creator>Durbin, P.W.</creator><creator>Raymond, K.N.</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199502</creationdate><title>Decorporation of thorium-228 from the rat by 3,4,3-LIHOPO and DTPA after simulated wound contamination</title><author>Stradling, G.N. ; Gray, S.A. ; Pearce, M.J. ; Wilson, I. ; Moody, J.C. ; Burgada, R. ; Durbin, P.W. ; Raymond, K.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-11437d17e5ee6d0d5956db4e5582cbcefbe56654404d9e1e46ca76e0576e2b993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Aza Compounds - administration & dosage</topic><topic>Aza Compounds - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intramuscular</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Subcutaneous</topic><topic>Kinetics</topic><topic>Ligands</topic><topic>Pentetic Acid - administration & dosage</topic><topic>Pentetic Acid - pharmacology</topic><topic>Pyridones - administration & dosage</topic><topic>Pyridones - pharmacology</topic><topic>Radiocontamination</topic><topic>Rats</topic><topic>Thorium Compounds - administration & dosage</topic><topic>Thorium Compounds - metabolism</topic><topic>Thorium Compounds - toxicity</topic><topic>Tissues, organs and organisms biophysics</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stradling, G.N.</creatorcontrib><creatorcontrib>Gray, S.A.</creatorcontrib><creatorcontrib>Pearce, M.J.</creatorcontrib><creatorcontrib>Wilson, I.</creatorcontrib><creatorcontrib>Moody, J.C.</creatorcontrib><creatorcontrib>Burgada, R.</creatorcontrib><creatorcontrib>Durbin, P.W.</creatorcontrib><creatorcontrib>Raymond, K.N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stradling, G.N.</au><au>Gray, S.A.</au><au>Pearce, M.J.</au><au>Wilson, I.</au><au>Moody, J.C.</au><au>Burgada, R.</au><au>Durbin, P.W.</au><au>Raymond, K.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decorporation of thorium-228 from the rat by 3,4,3-LIHOPO and DTPA after simulated wound contamination</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1995-02</date><risdate>1995</risdate><volume>14</volume><issue>2</issue><spage>165</spage><epage>169</epage><pages>165-169</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>1 With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treat ment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d.
2 In all cases 3,4,3-LIHOPO was appreciably more effec tive than DTPA although the efficacy of treatment and the relative effectiveness of the ligands decreased rapidly with their delay in administration.
3 Optimum removal with both ligands occurred when initial local administration at 30 min after exposure was followed by repeated intraperitoneal injection at 6 h, 1, 2 and 3 d. Under these conditions the body con tent of 228Th was reduced to 20% of controls after sc injection and 15% after im injection. The correspond ing values using repeated DTPA administration were 80% and 54%.
4 It is concluded that 3,4,3-LIHOPO represents, poten tially, a considerable advance on DTPA, the current agent of choice for the treatment of wounds contami nated by 228Th.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>7779440</pmid><doi>10.1177/096032719501400202</doi><tpages>5</tpages></addata></record> |
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| ispartof | Human & experimental toxicology, 1995-02, Vol.14 (2), p.165-169 |
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| source | MEDLINE; SAGE Complete A-Z List; Alma/SFX Local Collection |
| subjects | Animals Aza Compounds - administration & dosage Aza Compounds - pharmacology Biological and medical sciences Biological effects of radiation Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Injections, Intramuscular Injections, Intraperitoneal Injections, Subcutaneous Kinetics Ligands Pentetic Acid - administration & dosage Pentetic Acid - pharmacology Pyridones - administration & dosage Pyridones - pharmacology Radiocontamination Rats Thorium Compounds - administration & dosage Thorium Compounds - metabolism Thorium Compounds - toxicity Tissues, organs and organisms biophysics Wound Healing - drug effects |
| title | Decorporation of thorium-228 from the rat by 3,4,3-LIHOPO and DTPA after simulated wound contamination |
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