A Critical Review of the Optimum Duration of Chronic Rodent Testing for the Determination of Non-Tumourigenic Toxic Potential: A Report by the BTS Working Party on Duration of Toxicity Testing
This review indicates that for the detection of non-neoplastic toxic effects: 1 Four decades of accumulated literature provide no lead as to the optimum duration of repeat dose toxicity testing required for all classes of chemicals, although 6 months repeated administration appears adequate for phar...
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| Veröffentlicht in: | Human & Experimental Toxicology 1994-04, Vol.13 (4), p.221-232 |
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| container_title | Human & Experimental Toxicology |
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| creator | Betton, G. Cockburn, A. Harpur, E. Hopkins, J. Illing, P. Lumley, C. Connors, T. |
| description | This review indicates that for the detection of non-neoplastic toxic effects:
1 Four decades of accumulated literature provide no lead as to the optimum duration of repeat dose toxicity testing required for all classes of chemicals, although 6 months repeated administration appears adequate for pharmaceuticals.
2 Three month studies predicted the 2 year outcome for 70% of the compounds evaluated in this pilot study using data published by the US National Toxicology Program.
3 In spite of the limitations of this pilot study, this finding is considered encouraging as it is close to that generated previously on more detailed confidential pharmaceutical data.1,2 This suggests that the exercise should now be expanded using confidential surveys of industrial data to determine the concordance resulting from the evaluation of a larger group of chemicals. |
| doi_str_mv | 10.1177/096032719401300401 |
| format | Article |
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1 Four decades of accumulated literature provide no lead as to the optimum duration of repeat dose toxicity testing required for all classes of chemicals, although 6 months repeated administration appears adequate for pharmaceuticals.
2 Three month studies predicted the 2 year outcome for 70% of the compounds evaluated in this pilot study using data published by the US National Toxicology Program.
3 In spite of the limitations of this pilot study, this finding is considered encouraging as it is close to that generated previously on more detailed confidential pharmaceutical data.1,2 This suggests that the exercise should now be expanded using confidential surveys of industrial data to determine the concordance resulting from the evaluation of a larger group of chemicals.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719401300401</identifier><identifier>PMID: 8204306</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Hazardous Substances - administration & dosage ; Hazardous Substances - toxicity ; Medical sciences ; Mice ; Rats ; Time Factors ; Toxicology - methods ; Toxicology - standards ; Tumors</subject><ispartof>Human & Experimental Toxicology, 1994-04, Vol.13 (4), p.221-232</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4231-fe8b0e201e72b5733ef982c67f8daa300d64675725bca749a9c629d42ec83fd33</citedby><cites>FETCH-LOGICAL-c4231-fe8b0e201e72b5733ef982c67f8daa300d64675725bca749a9c629d42ec83fd33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719401300401$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719401300401$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>309,310,313,314,776,780,785,786,788,21800,23911,23912,25120,27901,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4016069$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8204306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Betton, G.</creatorcontrib><creatorcontrib>Cockburn, A.</creatorcontrib><creatorcontrib>Harpur, E.</creatorcontrib><creatorcontrib>Hopkins, J.</creatorcontrib><creatorcontrib>Illing, P.</creatorcontrib><creatorcontrib>Lumley, C.</creatorcontrib><creatorcontrib>Connors, T.</creatorcontrib><title>A Critical Review of the Optimum Duration of Chronic Rodent Testing for the Determination of Non-Tumourigenic Toxic Potential: A Report by the BTS Working Party on Duration of Toxicity Testing</title><title>Human & Experimental Toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>This review indicates that for the detection of non-neoplastic toxic effects:
1 Four decades of accumulated literature provide no lead as to the optimum duration of repeat dose toxicity testing required for all classes of chemicals, although 6 months repeated administration appears adequate for pharmaceuticals.
2 Three month studies predicted the 2 year outcome for 70% of the compounds evaluated in this pilot study using data published by the US National Toxicology Program.
3 In spite of the limitations of this pilot study, this finding is considered encouraging as it is close to that generated previously on more detailed confidential pharmaceutical data.1,2 This suggests that the exercise should now be expanded using confidential surveys of industrial data to determine the concordance resulting from the evaluation of a larger group of chemicals.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Hazardous Substances - administration & dosage</subject><subject>Hazardous Substances - toxicity</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Rats</subject><subject>Time Factors</subject><subject>Toxicology - methods</subject><subject>Toxicology - standards</subject><subject>Tumors</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1DAUtRCoTAs_gITkBWIX6kfGTthNp7ykilYliGXkODdTl8QebIcyf8en4cxEIyQkNtfSvedhnYPQC0reUCrlOSkF4UzSMieUE5LmI7SguZQZKQl_jBYTIJsQT9FpCPeEEFEu6Qk6KRjJOREL9HuF195Eo1WPb-GngQfsOhzvAF9voxnGAV-OXkXj7LRf33lnjca3rgUbcQUhGrvBnfN7yiVE8IOxR_xnZ7NqHNzozQYmYuV-pXnjYqIb1b_Fq-S6dT7iZreXuKi-4G_Of59kb5SPO5yU_v7CXsGk_Wz-DD3pVB_g-fyeoa_v31Xrj9nV9YdP69VVpnPGadZB0RBghIJkzVJyDl1ZMC1kV7RKpfBakQu5lGzZaCXzUpVasLLNGeiCdy3nZ-j1QXfr3Y8xedeDCRr6XllwY6gZTZlTLhKQHYDauxA8dPXWm0H5XU1JPdVW_1tbIr2c1cdmgPZImXtK91fzXYVUVeeV1SYcYUlCpGoT7PwAC2oD9X3K3aZM_mf8B7sOrkk</recordid><startdate>199404</startdate><enddate>199404</enddate><creator>Betton, G.</creator><creator>Cockburn, A.</creator><creator>Harpur, E.</creator><creator>Hopkins, J.</creator><creator>Illing, P.</creator><creator>Lumley, C.</creator><creator>Connors, T.</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>199404</creationdate><title>A Critical Review of the Optimum Duration of Chronic Rodent Testing for the Determination of Non-Tumourigenic Toxic Potential: A Report by the BTS Working Party on Duration of Toxicity Testing</title><author>Betton, G. ; Cockburn, A. ; Harpur, E. ; Hopkins, J. ; Illing, P. ; Lumley, C. ; Connors, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4231-fe8b0e201e72b5733ef982c67f8daa300d64675725bca749a9c629d42ec83fd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Hazardous Substances - administration & dosage</topic><topic>Hazardous Substances - toxicity</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Rats</topic><topic>Time Factors</topic><topic>Toxicology - methods</topic><topic>Toxicology - standards</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Betton, G.</creatorcontrib><creatorcontrib>Cockburn, A.</creatorcontrib><creatorcontrib>Harpur, E.</creatorcontrib><creatorcontrib>Hopkins, J.</creatorcontrib><creatorcontrib>Illing, P.</creatorcontrib><creatorcontrib>Lumley, C.</creatorcontrib><creatorcontrib>Connors, T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & Experimental Toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Betton, G.</au><au>Cockburn, A.</au><au>Harpur, E.</au><au>Hopkins, J.</au><au>Illing, P.</au><au>Lumley, C.</au><au>Connors, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Critical Review of the Optimum Duration of Chronic Rodent Testing for the Determination of Non-Tumourigenic Toxic Potential: A Report by the BTS Working Party on Duration of Toxicity Testing</atitle><jtitle>Human & Experimental Toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1994-04</date><risdate>1994</risdate><volume>13</volume><issue>4</issue><spage>221</spage><epage>232</epage><pages>221-232</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>This review indicates that for the detection of non-neoplastic toxic effects:
1 Four decades of accumulated literature provide no lead as to the optimum duration of repeat dose toxicity testing required for all classes of chemicals, although 6 months repeated administration appears adequate for pharmaceuticals.
2 Three month studies predicted the 2 year outcome for 70% of the compounds evaluated in this pilot study using data published by the US National Toxicology Program.
3 In spite of the limitations of this pilot study, this finding is considered encouraging as it is close to that generated previously on more detailed confidential pharmaceutical data.1,2 This suggests that the exercise should now be expanded using confidential surveys of industrial data to determine the concordance resulting from the evaluation of a larger group of chemicals.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>8204306</pmid><doi>10.1177/096032719401300401</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0960-3271 |
| ispartof | Human & Experimental Toxicology, 1994-04, Vol.13 (4), p.221-232 |
| issn | 0960-3271 1477-0903 |
| language | eng |
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| source | SAGE Complete A-Z List; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Hazardous Substances - administration & dosage Hazardous Substances - toxicity Medical sciences Mice Rats Time Factors Toxicology - methods Toxicology - standards Tumors |
| title | A Critical Review of the Optimum Duration of Chronic Rodent Testing for the Determination of Non-Tumourigenic Toxic Potential: A Report by the BTS Working Party on Duration of Toxicity Testing |
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