Reduction of Calbindin D-28k-Immunoreactive Neurons in the Dog Dentate Gyrus
The calcium binding protein calbindin D-28k (CB) plays an important role in modulating the activity of neurons in the dentate gyrus. We observed CB immunoreactivity in the dentate gyrus of dogs of various ages (German shepherds). In the 1-year-old group, CB immunoreactivity was detected in almost al...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2009, Vol.71(8), pp.1125-1128 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | CHOI, Jung Hoon HWANG, In Koo YOO, Ki-Yeon YI, Sun Shin PARK, Ok Kyu LEE, Choong Hyun YOON, Yeo Sung WON, Moo-Ho |
| description | The calcium binding protein calbindin D-28k (CB) plays an important role in modulating the activity of neurons in the dentate gyrus. We observed CB immunoreactivity in the dentate gyrus of dogs of various ages (German shepherds). In the 1-year-old group, CB immunoreactivity was detected in almost all of granule cells with poor processes. In the 8-year-old group, the number of CB-immunoreactive (+) neurons in the granule cell layer was significantly reduced (73.2% vs. 1-year-old group), while CB+ cell bodies and fibers were well developed. In the 10-year-old group, the number of CB+ neurons was further reduced by 31.3% when compared to that in the 1-year-old group. This finding demonstrates that the number of CB+ neurons decreases in the aged dog brain and this may be associated with reduction of function in the dentate gyrus. |
| doi_str_mv | 10.1292/jvms.71.1125 |
| format | Article |
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We observed CB immunoreactivity in the dentate gyrus of dogs of various ages (German shepherds). In the 1-year-old group, CB immunoreactivity was detected in almost all of granule cells with poor processes. In the 8-year-old group, the number of CB-immunoreactive (+) neurons in the granule cell layer was significantly reduced (73.2% vs. 1-year-old group), while CB+ cell bodies and fibers were well developed. In the 10-year-old group, the number of CB+ neurons was further reduced by 31.3% when compared to that in the 1-year-old group. This finding demonstrates that the number of CB+ neurons decreases in the aged dog brain and this may be associated with reduction of function in the dentate gyrus.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.71.1125</identifier><identifier>PMID: 19721372</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>aging ; Aging - physiology ; Animals ; calbindin D-28k ; Calbindins ; Cytoplasmic Granules - ultrastructure ; dentate gyrus ; Dentate Gyrus - cytology ; Dentate Gyrus - growth & development ; Dentate Gyrus - physiology ; Dogs - growth & development ; German shepherd ; granule cell ; Neurons - cytology ; Neurons - physiology ; S100 Calcium Binding Protein G - analysis ; S100 Calcium Binding Protein G - metabolism</subject><ispartof>Journal of Veterinary Medical Science, 2009, Vol.71(8), pp.1125-1128</ispartof><rights>2009 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-8c048d751be7d8282b1f584b28656f1ff3e443dd13fc76d6ae014e39b2d47703</citedby><cites>FETCH-LOGICAL-c538t-8c048d751be7d8282b1f584b28656f1ff3e443dd13fc76d6ae014e39b2d47703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19721372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHOI, Jung Hoon</creatorcontrib><creatorcontrib>HWANG, In Koo</creatorcontrib><creatorcontrib>YOO, Ki-Yeon</creatorcontrib><creatorcontrib>YI, Sun Shin</creatorcontrib><creatorcontrib>PARK, Ok Kyu</creatorcontrib><creatorcontrib>LEE, Choong Hyun</creatorcontrib><creatorcontrib>YOON, Yeo Sung</creatorcontrib><creatorcontrib>WON, Moo-Ho</creatorcontrib><title>Reduction of Calbindin D-28k-Immunoreactive Neurons in the Dog Dentate Gyrus</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>The calcium binding protein calbindin D-28k (CB) plays an important role in modulating the activity of neurons in the dentate gyrus. We observed CB immunoreactivity in the dentate gyrus of dogs of various ages (German shepherds). In the 1-year-old group, CB immunoreactivity was detected in almost all of granule cells with poor processes. In the 8-year-old group, the number of CB-immunoreactive (+) neurons in the granule cell layer was significantly reduced (73.2% vs. 1-year-old group), while CB+ cell bodies and fibers were well developed. In the 10-year-old group, the number of CB+ neurons was further reduced by 31.3% when compared to that in the 1-year-old group. This finding demonstrates that the number of CB+ neurons decreases in the aged dog brain and this may be associated with reduction of function in the dentate gyrus.</description><subject>aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>calbindin D-28k</subject><subject>Calbindins</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>dentate gyrus</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - growth & development</subject><subject>Dentate Gyrus - physiology</subject><subject>Dogs - growth & development</subject><subject>German shepherd</subject><subject>granule cell</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>S100 Calcium Binding Protein G - analysis</subject><subject>S100 Calcium Binding Protein G - metabolism</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0M1LwzAYx_Egis6Xm2cpCJ7szJOkTXqUzTcYCuI9pM1T7WwTTVrB_97OjQlekkM-_AhfQk6BToEV7Gr51cWphCkAy3bIBLiQqRS82CUTWkCeSpbRA3IY45JSBiIv9skBFJIBl2xCFs9oh6pvvEt8ncxMWzbONi6Zp0y9pw9dNzgf0IziC5NHHIJ3MRnf-zdM5v41maPrTY_J3XcY4jHZq00b8WRzH5GX25uX2X26eLp7mF0v0irjqk9VRYWyMoMSpVVMsRLqTImSqTzLa6hrjkJwa4HXlcxtbpCCQF6UzAopKT8iF-vZj-A_B4y97ppYYdsah36ImgFVRfYLz__BpR-CG7-mxxBKghpzjOpyrargYwxY64_QdCZ8a6B6lVivEmsJepV45Geb0aHs0P7hTdMRXK_BMvbmFbfAhL6pWtyuqfWxGt2-VW8maHT8B0ZEjUs</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>CHOI, Jung Hoon</creator><creator>HWANG, In Koo</creator><creator>YOO, Ki-Yeon</creator><creator>YI, Sun Shin</creator><creator>PARK, Ok Kyu</creator><creator>LEE, Choong Hyun</creator><creator>YOON, Yeo Sung</creator><creator>WON, Moo-Ho</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7QP</scope><scope>7TK</scope></search><sort><creationdate>20090101</creationdate><title>Reduction of Calbindin D-28k-Immunoreactive Neurons in the Dog Dentate Gyrus</title><author>CHOI, Jung Hoon ; HWANG, In Koo ; YOO, Ki-Yeon ; YI, Sun Shin ; PARK, Ok Kyu ; LEE, Choong Hyun ; YOON, Yeo Sung ; WON, Moo-Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-8c048d751be7d8282b1f584b28656f1ff3e443dd13fc76d6ae014e39b2d47703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>calbindin D-28k</topic><topic>Calbindins</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>dentate gyrus</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - growth & development</topic><topic>Dentate Gyrus - physiology</topic><topic>Dogs - growth & development</topic><topic>German shepherd</topic><topic>granule cell</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>S100 Calcium Binding Protein G - analysis</topic><topic>S100 Calcium Binding Protein G - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHOI, Jung Hoon</creatorcontrib><creatorcontrib>HWANG, In Koo</creatorcontrib><creatorcontrib>YOO, Ki-Yeon</creatorcontrib><creatorcontrib>YI, Sun Shin</creatorcontrib><creatorcontrib>PARK, Ok Kyu</creatorcontrib><creatorcontrib>LEE, Choong Hyun</creatorcontrib><creatorcontrib>YOON, Yeo Sung</creatorcontrib><creatorcontrib>WON, Moo-Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHOI, Jung Hoon</au><au>HWANG, In Koo</au><au>YOO, Ki-Yeon</au><au>YI, Sun Shin</au><au>PARK, Ok Kyu</au><au>LEE, Choong Hyun</au><au>YOON, Yeo Sung</au><au>WON, Moo-Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of Calbindin D-28k-Immunoreactive Neurons in the Dog Dentate Gyrus</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>71</volume><issue>8</issue><spage>1125</spage><epage>1128</epage><pages>1125-1128</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>The calcium binding protein calbindin D-28k (CB) plays an important role in modulating the activity of neurons in the dentate gyrus. We observed CB immunoreactivity in the dentate gyrus of dogs of various ages (German shepherds). In the 1-year-old group, CB immunoreactivity was detected in almost all of granule cells with poor processes. In the 8-year-old group, the number of CB-immunoreactive (+) neurons in the granule cell layer was significantly reduced (73.2% vs. 1-year-old group), while CB+ cell bodies and fibers were well developed. In the 10-year-old group, the number of CB+ neurons was further reduced by 31.3% when compared to that in the 1-year-old group. 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| subjects | aging Aging - physiology Animals calbindin D-28k Calbindins Cytoplasmic Granules - ultrastructure dentate gyrus Dentate Gyrus - cytology Dentate Gyrus - growth & development Dentate Gyrus - physiology Dogs - growth & development German shepherd granule cell Neurons - cytology Neurons - physiology S100 Calcium Binding Protein G - analysis S100 Calcium Binding Protein G - metabolism |
| title | Reduction of Calbindin D-28k-Immunoreactive Neurons in the Dog Dentate Gyrus |
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