Amphetamine reduces vesicular dopamine content in dexamethasone-differentiated PC12 cells only following l-DOPA exposure

Amphetamine (AMPH) increases brain dopamine (DA) levels via reversal of the membrane DA transporter. Additional mechanisms have been suggested, including inhibition of vesicular monoamine transporters and vesicular leakage of DA and Ca²⁺. According to the widely-accepted weak base theory, AMPH disru...

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Veröffentlicht in:	Journal of neurochemistry 2009-10, Vol.111 (2), p.624-633
Hauptverfasser:	Hondebrink, Laura, Meulenbelt, Jan, Timmerman, Johan G, van den Berg, Martin, Westerink, Remco H.S
Format:	Artikel
Sprache:	eng
Schlagworte:	amperometry Amphetamine - pharmacology Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Ca2+ homeostasis Calcium - metabolism Ca²⁺ homeostasis Cell Differentiation - drug effects Cell Survival - drug effects Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Chromaffin Cells - cytology Chromaffin Cells - drug effects Dexamethasone - pharmacology Dopamine - metabolism Dopamine Agents - pharmacology Drug Interactions drugs of abuse exocytosis Female Fundamental and applied biological sciences. Psychology Glucocorticoids - pharmacology large dense-core vesicle Levodopa - pharmacology Male Medical sciences Mice Mice, Inbred C57BL Neurons - cytology Neurons - drug effects Neuropharmacology PC12 Cells Pharmacology. Drug treatments Rats Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism Vertebrates: nervous system and sense organs vesicular catecholamine release
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