Silencing of perilipin by short hairpin RNA inhibits proliferation and induces apoptosis in liposarcoma cells

Previous studies have identified that perilipin-1 (PLIN1) is a highly specific marker for liposarcoma. However, its functions have yet to be fully elucidated. The aim of the present study was to investigate the potential role of PLIN1 in the proliferation, migration and apoptosis of liposarcoma cell...

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Veröffentlicht in:	Molecular medicine reports 2018-11, Vol.18 (5), p.4571-4576
Hauptverfasser:	Meng, Ling-Xin, Zheng, Yu-Xiu, He, Mao-Lei, Zhou, Xiao-Ming, Sun, Shu-Yan, Ding, Zhao-Jun, Meng, Qin, Li, Bing-Cheng, Sun, Yan-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Apoptosis Apoptosis - genetics Breast cancer Care and treatment Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Chemotherapy Development and progression Experiments Flow Cytometry G1 phase G1 Phase Cell Cycle Checkpoints - genetics Gene Expression Regulation, Neoplastic - genetics Genetic aspects Health aspects Humans Lipids Liposarcoma Liposarcoma - genetics Liposarcoma - pathology Metastasis Pathogenesis Perilipin-1 - antagonists & inhibitors Perilipin-1 - genetics Proteins Radiation therapy Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics Spermatogenesis Therapeutic applications Tumor markers Tumorigenesis Tumors Wound healing
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