The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila

We have identified Rabconnectin-3a and b (Rbcn-3A and B) as two regulators of Notch signaling in Drosophila. We found that, in addition to disrupting Notch signaling, mutations in Rbcn-3A and B cause defects in endocytic trafficking, where Notch and other membrane proteins accumulate in late endosom...

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Veröffentlicht in:	Developmental cell 2009-09, Vol.17 (3), p.387-402
Hauptverfasser:	Yan, Yan, Denef, Natalie, Schuepbach, Trudi
Format:	Artikel
Sprache:	eng
Schlagworte:	Drosophila
Online-Zugang:	Volltext
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