Thienopyrimidine-based P2Y sub(12) platelet aggregation inhibitors

Thienopyrimidine-based P2Y sub(12) platelet aggregation inhibitors

Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y sub(12) inhibitors and the negative impact protein binding has on the inhibition of platelet aggregation.

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2009-10, Vol.19 (20), p.5919-5923
Hauptverfasser: Kortum, Steven W, Lachance, Rhonda M, Schweitzer, Barbara A, Yalamanchili, Gopichand, Rahman, Hayat, Ennis, Michael D, Huff, Rita M, TenBrink, Ruth E
Format: Artikel
Sprache:eng
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Zusammenfassung:Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y sub(12) inhibitors and the negative impact protein binding has on the inhibition of platelet aggregation.
ISSN:0960-894X
DOI:10.1016/j.bmcl.2009.08.059