Distribution of nickel in body fluids and organs of rats chronically exposed to nickel sulphate
1 Male and female rats were given 100 mg Ni L-1 (as nick el sulphate) in drinking water for 6 months. 2 The feeding of nickel was associated with an increased concentration of nickel in body fluids and organs. The highest concentrations of nickel were found in the liver of both male and female rats....
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| Veröffentlicht in: | Human & experimental toxicology 1995-12, Vol.14 (12), p.955-958 |
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| creator | Severa, J. Vyskocil, A. Fiala, Z. Cizkova, M. |
| description | 1 Male and female rats were given 100 mg Ni L-1 (as nick el sulphate) in drinking water for 6 months.
2 The feeding of nickel was associated with an increased concentration of nickel in body fluids and organs. The highest concentrations of nickel were found in the liver of both male and female rats. In male rats nickel levels decreased in the order: liver > kidney = whole blood = serum > testes > urine. In female rats the decreasing order was similar: liver > kidney = whole blood = serum = plasma > urine > ovaries.
3 No significant differences were found between nickel concentrations in organs (except ovaries), blood and urine of rats exposed for 3 months and those exposed for 6 months indicating the reaching of a steady state of nickel in the rat during long-term exposure.
4 The urinary excretion of the orally administered nickel was only 2% of absorbed dose (supposing 1% Ni absorp tion). |
| doi_str_mv | 10.1177/096032719501401204 |
| format | Article |
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2 The feeding of nickel was associated with an increased concentration of nickel in body fluids and organs. The highest concentrations of nickel were found in the liver of both male and female rats. In male rats nickel levels decreased in the order: liver > kidney = whole blood = serum > testes > urine. In female rats the decreasing order was similar: liver > kidney = whole blood = serum = plasma > urine > ovaries.
3 No significant differences were found between nickel concentrations in organs (except ovaries), blood and urine of rats exposed for 3 months and those exposed for 6 months indicating the reaching of a steady state of nickel in the rat during long-term exposure.
4 The urinary excretion of the orally administered nickel was only 2% of absorbed dose (supposing 1% Ni absorp tion).</description><identifier>ISSN: 0960-3271</identifier><identifier>ISSN: 0144-5952</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719501401204</identifier><identifier>PMID: 8962746</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Female ; Irritants - administration & dosage ; Irritants - pharmacokinetics ; Irritants - toxicity ; Kidney - drug effects ; Kidney - metabolism ; Liver - drug effects ; Liver - metabolism ; Male ; Medical sciences ; Metals and various inorganic compounds ; Nickel - administration & dosage ; Nickel - blood ; Nickel - pharmacokinetics ; Nickel - toxicity ; Nickel - urine ; Ovary - drug effects ; Ovary - metabolism ; Rats ; Testis - drug effects ; Testis - metabolism ; Tissue Distribution ; Toxicology</subject><ispartof>Human & experimental toxicology, 1995-12, Vol.14 (12), p.955-958</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-8d563ab755f8bcfef6e3611878dabbdffd190e261644410f8c885ebe52f378fd3</citedby><cites>FETCH-LOGICAL-c429t-8d563ab755f8bcfef6e3611878dabbdffd190e261644410f8c885ebe52f378fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719501401204$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719501401204$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2956171$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8962746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Severa, J.</creatorcontrib><creatorcontrib>Vyskocil, A.</creatorcontrib><creatorcontrib>Fiala, Z.</creatorcontrib><creatorcontrib>Cizkova, M.</creatorcontrib><title>Distribution of nickel in body fluids and organs of rats chronically exposed to nickel sulphate</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>1 Male and female rats were given 100 mg Ni L-1 (as nick el sulphate) in drinking water for 6 months.
2 The feeding of nickel was associated with an increased concentration of nickel in body fluids and organs. The highest concentrations of nickel were found in the liver of both male and female rats. In male rats nickel levels decreased in the order: liver > kidney = whole blood = serum > testes > urine. In female rats the decreasing order was similar: liver > kidney = whole blood = serum = plasma > urine > ovaries.
3 No significant differences were found between nickel concentrations in organs (except ovaries), blood and urine of rats exposed for 3 months and those exposed for 6 months indicating the reaching of a steady state of nickel in the rat during long-term exposure.
4 The urinary excretion of the orally administered nickel was only 2% of absorbed dose (supposing 1% Ni absorp tion).</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Female</subject><subject>Irritants - administration & dosage</subject><subject>Irritants - pharmacokinetics</subject><subject>Irritants - toxicity</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Nickel - administration & dosage</subject><subject>Nickel - blood</subject><subject>Nickel - pharmacokinetics</subject><subject>Nickel - toxicity</subject><subject>Nickel - urine</subject><subject>Ovary - drug effects</subject><subject>Ovary - metabolism</subject><subject>Rats</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Tissue Distribution</subject><subject>Toxicology</subject><issn>0960-3271</issn><issn>0144-5952</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAURYMo4zj6BwQhC3FXzUvbJF2K3yC40XVJm2SMdpoxrwXn35thRjeCrt7innsfHEKOgZ0DSHnBKsFyLqEqGRQMOCt2yBQKKTNWsXyXTNdAtib2yQHiG2NMVCVMyERVgstCTEl97XGIvhkHH3oaHO19-2476nvaBLOirhu9Qap7Q0Oc6x7XTNQD0vY1hgTrrltR-7kMaA0dwncfx275qgd7SPac7tAebe-MvNzePF_dZ49Pdw9Xl49ZW_BqyJQpRa4bWZZONa2zTthcACipjG4a45yBilkuQBRFAcypVqnSNrbkLpfKmXxGzja7yxg-RotDvfDY2q7TvQ0j1hyYFGn-XxBkcqmS1xnhG7CNATFaVy-jX-i4qoHVa_31b_2pdLJdH5uFNT-Vre-Un25zjUmdi7pvPf5gvCoFSEjYxQZDPbf1Wxhjn-T99fgLGC-aig</recordid><startdate>19951201</startdate><enddate>19951201</enddate><creator>Severa, J.</creator><creator>Vyskocil, A.</creator><creator>Fiala, Z.</creator><creator>Cizkova, M.</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19951201</creationdate><title>Distribution of nickel in body fluids and organs of rats chronically exposed to nickel sulphate</title><author>Severa, J. ; Vyskocil, A. ; Fiala, Z. ; Cizkova, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-8d563ab755f8bcfef6e3611878dabbdffd190e261644410f8c885ebe52f378fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Female</topic><topic>Irritants - administration & dosage</topic><topic>Irritants - pharmacokinetics</topic><topic>Irritants - toxicity</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Nickel - administration & dosage</topic><topic>Nickel - blood</topic><topic>Nickel - pharmacokinetics</topic><topic>Nickel - toxicity</topic><topic>Nickel - urine</topic><topic>Ovary - drug effects</topic><topic>Ovary - metabolism</topic><topic>Rats</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Tissue Distribution</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Severa, J.</creatorcontrib><creatorcontrib>Vyskocil, A.</creatorcontrib><creatorcontrib>Fiala, Z.</creatorcontrib><creatorcontrib>Cizkova, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Severa, J.</au><au>Vyskocil, A.</au><au>Fiala, Z.</au><au>Cizkova, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of nickel in body fluids and organs of rats chronically exposed to nickel sulphate</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1995-12-01</date><risdate>1995</risdate><volume>14</volume><issue>12</issue><spage>955</spage><epage>958</epage><pages>955-958</pages><issn>0960-3271</issn><issn>0144-5952</issn><eissn>1477-0903</eissn><abstract>1 Male and female rats were given 100 mg Ni L-1 (as nick el sulphate) in drinking water for 6 months.
2 The feeding of nickel was associated with an increased concentration of nickel in body fluids and organs. The highest concentrations of nickel were found in the liver of both male and female rats. In male rats nickel levels decreased in the order: liver > kidney = whole blood = serum > testes > urine. In female rats the decreasing order was similar: liver > kidney = whole blood = serum = plasma > urine > ovaries.
3 No significant differences were found between nickel concentrations in organs (except ovaries), blood and urine of rats exposed for 3 months and those exposed for 6 months indicating the reaching of a steady state of nickel in the rat during long-term exposure.
4 The urinary excretion of the orally administered nickel was only 2% of absorbed dose (supposing 1% Ni absorp tion).</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>8962746</pmid><doi>10.1177/096032719501401204</doi><tpages>4</tpages></addata></record> |
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| ispartof | Human & experimental toxicology, 1995-12, Vol.14 (12), p.955-958 |
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| source | Access via SAGE; MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Oral Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Female Irritants - administration & dosage Irritants - pharmacokinetics Irritants - toxicity Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Medical sciences Metals and various inorganic compounds Nickel - administration & dosage Nickel - blood Nickel - pharmacokinetics Nickel - toxicity Nickel - urine Ovary - drug effects Ovary - metabolism Rats Testis - drug effects Testis - metabolism Tissue Distribution Toxicology |
| title | Distribution of nickel in body fluids and organs of rats chronically exposed to nickel sulphate |
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