Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus

In the search for strategies to treat schizophrenia, attention has focused on enhancing NMDA receptor function. In vitro experiments show that metabotropic glutamate 5 receptor (mGluR5) activation enhances NMDA receptor activity, and in vivo experiments indicate that mGluR5 positive allosteric modul...

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Veröffentlicht in:	Neuropharmacology 2009-10, Vol.57 (5), p.531-538
Hauptverfasser:	Uslaner, Jason M., Parmentier-Batteur, Sophie, Flick, Rosemarie B., Surles, Nathaniel O., Lam, June S.H., McNaughton, Caitlyn H., Jacobson, Marlene A., Hutson, Pete H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - administration & dosage Benzamides - pharmacology Brain - drug effects Brain - physiology Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Central Nervous System Agents - administration & dosage Central Nervous System Agents - pharmacology Cognition Cyclic AMP Response Element-Binding Protein - metabolism Dizocilpine Maleate Dose-Response Relationship, Drug Glutamate Hippocampus - drug effects Hippocampus - physiology Male Memory Disorders - chemically induced Memory Disorders - drug therapy Metabotropic Neuronal Plasticity - drug effects Neuronal Plasticity - physiology NMDA Novel object recognition Phosphorylation - drug effects Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Pyrazoles - administration & dosage Pyrazoles - pharmacology Rats Rats, Wistar Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Recognition (Psychology) - drug effects Recognition (Psychology) - physiology Schizophrenia
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