Hibifolin, a flavonol glycoside, prevents β-amyloid-induced neurotoxicity in cultured cortical neurons

The toxicity of aggregated β-amyloid (Aβ) has been implicated as a critical cause in the development of Alzheimer's disease (AD). Hibifolin, a flavonol glycoside derived from herbal plants, possessed a strong protective activity against cell death induced by aggregated Aβ. Application of hibifo...

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Veröffentlicht in:	Neuroscience letters 2009-09, Vol.461 (2), p.172-176
Hauptverfasser:	Zhu, Judy T.T., Choi, Roy C.Y., Xie, Heidi Q., Zheng, Ken Y.Z., Guo, Ava J.Y., Bi, Cathy W.C., Lau, David T.W., Li, Jun, Dong, Tina T.X., Lau, Brad W.C., Chen, Ji J., Tsim, Karl W.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - physiology Amyloid beta-Peptides - toxicity Animals Apoptosis - drug effects Biological and medical sciences Calcium - metabolism Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Cortical neuron Flavonoid Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Hibifolin Neurons - cytology Neurons - drug effects Neuroprotection Neuroprotective Agents - pharmacology Peptide Fragments - physiology Peptide Fragments - toxicity Proto-Oncogene Proteins c-akt - physiology Rats Signal Transduction Vertebrates: nervous system and sense organs
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