Lactation is a natural model of hippocampus neuroprotection against excitotoxicity
Lactation is a temporary but complex physiological condition in which hormones and neurogenic stimulation from suckling cause maternal brain plasticity. It has been shown that lactation prevents cell damage induced by excitotoxicity in the dorsal hippocampus of the dam after peripheral administratio...
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| Veröffentlicht in: | Neuroscience letters 2009-09, Vol.461 (2), p.136-139 |
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| container_title | Neuroscience letters |
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| creator | Cabrera, Verónica Cantú, Daniel Ramos, Eugenia Vanoye-Carlo, América Cerbón, Marco Morales, Teresa |
| description | Lactation is a temporary but complex physiological condition in which hormones and neurogenic stimulation from suckling cause maternal brain plasticity. It has been shown that lactation prevents cell damage induced by excitotoxicity in the dorsal hippocampus of the dam after peripheral administration of kainic acid (KA). The aim of this study was to determine whether lactation protects the maternal hippocampus against damage induced by intracerebral application (ICV) of KA and if lactation decreases, or only delays, this damaging effect of KA. Cell damage was assessed by Fluoro-Jade C staining in the hippocampus of virgin and lactating rats 24 or 72
h after ICV KA. Lactation prevented cell damage of the pyramidal layers of the hippocampus (CA1, CA3, and CA4), as compared to virgin rats. The longer period of KA exposure increased the difference in cell damage between these two conditions. The present results confirm that lactation is a natural model for neuroprotection, since it effectively prevents acute and chronic cell damage of the hippocampus induced by exposure to KA. |
| doi_str_mv | 10.1016/j.neulet.2009.06.017 |
| format | Article |
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h after ICV KA. Lactation prevented cell damage of the pyramidal layers of the hippocampus (CA1, CA3, and CA4), as compared to virgin rats. The longer period of KA exposure increased the difference in cell damage between these two conditions. The present results confirm that lactation is a natural model for neuroprotection, since it effectively prevents acute and chronic cell damage of the hippocampus induced by exposure to KA.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2009.06.017</identifier><identifier>PMID: 19539698</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cell Death ; Excitatory Amino Acid Agonists - administration & dosage ; Excitatory Amino Acid Agonists - toxicity ; Excitotoxicity ; Female ; Fluoro-Jade C ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - pathology ; Injections, Intraventricular ; Kainic acid ; Kainic Acid - administration & dosage ; Kainic Acid - toxicity ; Lactation ; Neurons - drug effects ; Neurons - pathology ; Neuroprotection ; Rats ; Rats, Wistar ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2009-09, Vol.461 (2), p.136-139</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-6ade6f963e4244f24c7b6c23c68c63ce6f0af1b5aa069138480c9ce7a2a659c13</citedby><cites>FETCH-LOGICAL-c421t-6ade6f963e4244f24c7b6c23c68c63ce6f0af1b5aa069138480c9ce7a2a659c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394009008015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21728277$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19539698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cabrera, Verónica</creatorcontrib><creatorcontrib>Cantú, Daniel</creatorcontrib><creatorcontrib>Ramos, Eugenia</creatorcontrib><creatorcontrib>Vanoye-Carlo, América</creatorcontrib><creatorcontrib>Cerbón, Marco</creatorcontrib><creatorcontrib>Morales, Teresa</creatorcontrib><title>Lactation is a natural model of hippocampus neuroprotection against excitotoxicity</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Lactation is a temporary but complex physiological condition in which hormones and neurogenic stimulation from suckling cause maternal brain plasticity. It has been shown that lactation prevents cell damage induced by excitotoxicity in the dorsal hippocampus of the dam after peripheral administration of kainic acid (KA). The aim of this study was to determine whether lactation protects the maternal hippocampus against damage induced by intracerebral application (ICV) of KA and if lactation decreases, or only delays, this damaging effect of KA. Cell damage was assessed by Fluoro-Jade C staining in the hippocampus of virgin and lactating rats 24 or 72
h after ICV KA. Lactation prevented cell damage of the pyramidal layers of the hippocampus (CA1, CA3, and CA4), as compared to virgin rats. The longer period of KA exposure increased the difference in cell damage between these two conditions. The present results confirm that lactation is a natural model for neuroprotection, since it effectively prevents acute and chronic cell damage of the hippocampus induced by exposure to KA.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Death</subject><subject>Excitatory Amino Acid Agonists - administration & dosage</subject><subject>Excitatory Amino Acid Agonists - toxicity</subject><subject>Excitotoxicity</subject><subject>Female</subject><subject>Fluoro-Jade C</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Injections, Intraventricular</subject><subject>Kainic acid</subject><subject>Kainic Acid - administration & dosage</subject><subject>Kainic Acid - toxicity</subject><subject>Lactation</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Neuroprotection</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGKFDEQhoMo7uzqG4j0RW_dJul00rkIsqgrDAii51BTXa0ZujttkpbdtzfjDHrzVIf6_r-Kj7EXgjeCC_3m2Cy0TZQbybltuG64MI_YTvRG1sYa-ZjteMtV3VrFr9h1SkfOeSc69ZRdCdu1Vtt-x77sATNkH5bKpwqqBfIWYarmMNBUhbH64dc1IMzrlqpyMIY1hkz4JwHfwS8pV3SPPocc7n2ZD8_YkxGmRM8v84Z9-_D-6-1dvf_88dPtu32NSopcaxhIj1a3pKRSo1RoDhpli7pH3WLZcRjFoQPg2oq2Vz1Hi2RAgu4sivaGvT73lo9-bpSym31CmiZYKGzJScGN6PsTqM4gxpBSpNGt0c8QH5zg7uTSHd3ZpTu5dFy74rLEXl76t8NMw7_QRV4BXl0ASAjTGGFBn_5yUhjZS3MqenvmqNj45Sm6hJ4WpMHHYtINwf__k9-8DZXt</recordid><startdate>20090918</startdate><enddate>20090918</enddate><creator>Cabrera, Verónica</creator><creator>Cantú, Daniel</creator><creator>Ramos, Eugenia</creator><creator>Vanoye-Carlo, América</creator><creator>Cerbón, Marco</creator><creator>Morales, Teresa</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20090918</creationdate><title>Lactation is a natural model of hippocampus neuroprotection against excitotoxicity</title><author>Cabrera, Verónica ; Cantú, Daniel ; Ramos, Eugenia ; Vanoye-Carlo, América ; Cerbón, Marco ; Morales, Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-6ade6f963e4244f24c7b6c23c68c63ce6f0af1b5aa069138480c9ce7a2a659c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Death</topic><topic>Excitatory Amino Acid Agonists - administration & dosage</topic><topic>Excitatory Amino Acid Agonists - toxicity</topic><topic>Excitotoxicity</topic><topic>Female</topic><topic>Fluoro-Jade C</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - pathology</topic><topic>Injections, Intraventricular</topic><topic>Kainic acid</topic><topic>Kainic Acid - administration & dosage</topic><topic>Kainic Acid - toxicity</topic><topic>Lactation</topic><topic>Neurons - drug effects</topic><topic>Neurons - pathology</topic><topic>Neuroprotection</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cabrera, Verónica</creatorcontrib><creatorcontrib>Cantú, Daniel</creatorcontrib><creatorcontrib>Ramos, Eugenia</creatorcontrib><creatorcontrib>Vanoye-Carlo, América</creatorcontrib><creatorcontrib>Cerbón, Marco</creatorcontrib><creatorcontrib>Morales, Teresa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cabrera, Verónica</au><au>Cantú, Daniel</au><au>Ramos, Eugenia</au><au>Vanoye-Carlo, América</au><au>Cerbón, Marco</au><au>Morales, Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactation is a natural model of hippocampus neuroprotection against excitotoxicity</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2009-09-18</date><risdate>2009</risdate><volume>461</volume><issue>2</issue><spage>136</spage><epage>139</epage><pages>136-139</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Lactation is a temporary but complex physiological condition in which hormones and neurogenic stimulation from suckling cause maternal brain plasticity. It has been shown that lactation prevents cell damage induced by excitotoxicity in the dorsal hippocampus of the dam after peripheral administration of kainic acid (KA). The aim of this study was to determine whether lactation protects the maternal hippocampus against damage induced by intracerebral application (ICV) of KA and if lactation decreases, or only delays, this damaging effect of KA. Cell damage was assessed by Fluoro-Jade C staining in the hippocampus of virgin and lactating rats 24 or 72
h after ICV KA. Lactation prevented cell damage of the pyramidal layers of the hippocampus (CA1, CA3, and CA4), as compared to virgin rats. The longer period of KA exposure increased the difference in cell damage between these two conditions. The present results confirm that lactation is a natural model for neuroprotection, since it effectively prevents acute and chronic cell damage of the hippocampus induced by exposure to KA.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19539698</pmid><doi>10.1016/j.neulet.2009.06.017</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cell Death Excitatory Amino Acid Agonists - administration & dosage Excitatory Amino Acid Agonists - toxicity Excitotoxicity Female Fluoro-Jade C Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - pathology Injections, Intraventricular Kainic acid Kainic Acid - administration & dosage Kainic Acid - toxicity Lactation Neurons - drug effects Neurons - pathology Neuroprotection Rats Rats, Wistar Time Factors Vertebrates: nervous system and sense organs |
| title | Lactation is a natural model of hippocampus neuroprotection against excitotoxicity |
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